초록

급성 뇌경색환자의 세절편 CT사진에서 소프트웨어를 이용한 혈전영상분석을 통해 혈전용해치료 또는 혈전제거치료후의 혈관재개통을 예측할 수 있음. 혈전영상분석을 통해 혈전용해치료를 해도 혈관재개통이 되지 않을 경우를 미리 선별할 수 잇고, 치료전략을 세우는데 도움이 될 수 있음.

( 출처: 보고서 요약서 3p )

Abstract ▼

Purpose&Contents
- This study aims to provide clinical evidence of thrombus imaging for the prediction of outcome in stroke.
- This study included a restropective cohort to develop a CT marker of thrombus for predicting recanalization/non-recanalization after intravenous thrombolysis thromboly

Purpose&Contents
- This study aims to provide clinical evidence of thrombus imaging for the prediction of outcome in stroke.
- This study included a restropective cohort to develop a CT marker of thrombus for predicting recanalization/non-recanalization after intravenous thrombolysis thrombolysis (IVT) or mechanical thrombectomy using a stent retriever. As the CT marker of thrombus, the volume and denisty of thrombus were measured using a 3-dimensional software. The determined CT marker for predicting recanalization/nonrecanalization was validated in a prospective multicenter study, We also improved the software to be user-friendly.

Results
- We determined the imaging marker for thrombus for predicting nonrecanalization after IVT in the retrospective cohort. The cutoff for predicting non-recanalization was calculated as 200 mm³. In the prospective multicenter validation study, none of the patients with a thrombus volume ≥200 mm³ achieved successful recanalization. The sensitivity of the cutoff of 200mm³ for predicting non-recanalization was 96.2% in the retrospective cohort and 100% in the prospective validation cohort. The small thrombus volume was associated with excellent functional outcome at 3 months.
- We determined the imaging marker for thrombus predicting recanalization after mechanical thrombectomy using a stent retriever in the retrospective cohort. The recanalization was achieved with the first pass in 68 (50.0%). The thrombus volume was an independent predictor of first-pass recanalization. The cutoff for predicting the first-pass recanalization was calculated as 76.4mm³.
The sensitivity and specificity of the cutoff was 55.9% and 74.4% in the retroapective cohrot and 54.5% and 61.1% in the prospective validation cohort, respectivley.
- The 3-dimenstional imaging software was improved to be user-friendly. By this improvement, the volume and density of thrombus could be measured in about 1 min in most cases,

Expected Contribution
- The thrombus imaging will be helpful for screening stroke patients who may not need IVT.
- The thrombus imaging may be used for assessing the efficacy of new thrombolytic drugs.
- The analysis tool in this study is based on CT. As a CT scan is available in almost all hospitals, the utility of this software ben The selection of patients who will benefit from recanalization therapy will be feasible

( 출처 : SUMMARY 5p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• Table of contents ... 6
• 목차 ... 7
• 1. 연구개발과제의 개요 ... 8
• 1-1. 연구개발 목적 ... 8
• 1-2. 연구개발의 필요성 ... 8
• 1-3. 연구개발 범위 ... 12
• 2. 국내외 기술개발 현황 ... 14
• 3. 연구수행 내용 및 결과 ... 14
• 4. 목표달성도 및 관련분야 기여도 ... 20
• 4-1. 목표달성도 ... 20
• 4-2. 관련분야 기여도 ... 21
• 5. 연구결과의 활용계획 ... 21
• 6. 연구과정에서 수집한 해외과학기술정보 ... 22
• 7. 연구개발성과의 보안등급 ... 23
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 24
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 25
• 10. 연구개발과제의 대표적 연구실적 ... 26
• 11. 기타사항 ... 27
• 12. 참고문헌 ... 28
• [별첨4] 실적 증빙자료 ... 29
• 끝페이지 ... 37