초록 ▼

1. 퇴행성관절염 동물모델 확립 및 유효성, 안전성 평가
· 중형동물모델에서의 퇴행성관절염 모델 확립 및 유효성, 안전성 평가
· 자연발생적 퇴행성관절염 중형동물 모델 확립 및 유효성, 안전성 평가
· 퇴행성관절염 치료제로서, 생리활성펩타이드의 항염, 자가세포사멸 억제 활성 확보

2. 퇴행성관절염 치료제의 성능 최적화 및 표준화 근거를 확립함
· 생리활성 펩타이드의 제조방법, 혼합비율 및 주입 전 전처리 방법의 프로토콜을 정립함.
· 동물모델에서의 치료효과를 종합하여 생리활성 펩타이드의 적정

1. 퇴행성관절염 동물모델 확립 및 유효성, 안전성 평가
· 중형동물모델에서의 퇴행성관절염 모델 확립 및 유효성, 안전성 평가
· 자연발생적 퇴행성관절염 중형동물 모델 확립 및 유효성, 안전성 평가
· 퇴행성관절염 치료제로서, 생리활성펩타이드의 항염, 자가세포사멸 억제 활성 확보

2. 퇴행성관절염 치료제의 성능 최적화 및 표준화 근거를 확립함
· 생리활성 펩타이드의 제조방법, 혼합비율 및 주입 전 전처리 방법의 프로토콜을 정립함.
· 동물모델에서의 치료효과를 종합하여 생리활성 펩타이드의 적정 농도, 적정 투여용량, 적정 투여횟수 및 적정 투여기간을 확립함.

3. 논문 실적 6건 / 특허 3건 확보

(출처 : 보고서 요약서 3p)

Abstract ▼

Purpose&Contents
■ Purpose : We developed a biological active peptide nanofiber with a microenvironment structure which is not only for maximization of self-healing by inflammation control and inducing of endogeneous stem cell in human body, but also increase rate of engraftment and efficiency of

Purpose&Contents
■ Purpose : We developed a biological active peptide nanofiber with a microenvironment structure which is not only for maximization of self-healing by inflammation control and inducing of endogeneous stem cell in human body, but also increase rate of engraftment and efficiency of stem cell in order to inhibit the progression of degenerative arthritis and ensure full treatment by regenerating the damaged cartilage tissue.

Moreover, we developed an original and practical use of the new concept, Stem cell Therapy Product, which is used to inhibit the progression of degenerative arthritis and regeneration of cartilage. This product can control the physiological condition of the body and it’s efficiency was maximized. Improved effect and safety of this medical treatment was proven through evaluation of efficacy and safety with animals given degenerative arthritis.

■ Contents : Based on the past research about treatment effect of degenerative arthritis applied for small-sized animal, this research is to find the result in the middle-sized animal. By developing biological active peptide nanofiber for inflammation control and inducing endogenous stem cell, a degenrative arthritis model in middle-sized animal is made to apply for them. Commited institution conducted a experiment about effect on joint inflammation and observed some difference with past research and treatment effect as time passed. The rabbits are used for making degenerative arthritis model as middle sized animal using surgical procedure, and Dunkin Hartley Guinea pigs are also used for it because they are spontaneous arthritis model and have many similar things in people. Effectiveness of medicine is estimated by comparing results between control group and the group injected biological active peptide nanofiber as a treatment of degenerative arthritis.

Results
1. Establishing animal models of degenerative arthritis and evaluation of efficacy and safety
· Establishing animal models of degenerative arthritis and evaluation of efficacy and safety in middle-sized animal models
· Establishment of spontaneously degenerative arthritis and evaluation of efficacy and safety in middle-sized animal models
· Establishment of the anti-inflammatory of biological active peptide and suppressing apoptosis effects as a degenerative arthritis drug

2. Establishing basis for optimization and standardization of therapeutic osteoarthritis agents
· Establishment of self-assembled peptide of the manufacture protocol
· Combining the therapeutic effects of various animal models and establishing the adequate concentration, administration and term of self-assembled peptide

3. Six research papers(top 20% of JCR) and three patents were published

Expected Contribution
■ The ripple effect of Technology : It is expected to be applied to industry not only as playing a leading role in the field of biomaterial at home and abroad, but as medicine for the incurable disease, degenerative arthritis.

■ The Economic impact : As a medical field to prepare for an aging society, the development of injection-type peptide treatment substance will contribute to the government-run medical research industry.

■ Possibility of Clinical application and Utilizing development result :
Using the results of the small to medium sized animal testing as a background, prepare for the initiation of clinical trials on patients. It is expected that the medicine will have an effect on arthritis occurred at various part of joint such as osteoarthritis.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• Contents ... 7
• 목차 ... 8
• 1. 연구개발과제의 개요 ... 9
• 1-1. 연구개발 목적 ... 9
• 1-2. 연구개발의 필요성 ... 10
• 1-3. 연구개발 범위 ... 12
• 2. 국내외 기술개발 현황 ... 14
• 3. 연구수행 내용 및 결과 ... 17
• 4. 목표달성도 및 관련분야 기여도 ... 35
• 4-1. 목표달성도 ... 35
• 4-2. 관련분야 기여도 ... 36
• 5. 연구결과의 활용계획 ... 38
• 6. 연구과정에서 수집한 해외과학기술정보 ... 41
• 7. 연구개발성과의 보안등급 ... 43
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 44
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 45
• 10. 연구개발과제의 대표적 연구실적 ... 46
• 11. 기타사항 ... 47
• 12. 참고문헌 ... 48
• [별첨4] 실적 증빙자료 ... 49
• 끝페이지 ... 70