초록 ▼

✓ in vivo 효능 및 안전성 평가를 위해 KDS2010 125g을 합성하였음
✓ 2주 반복독성 시험에서 NOAEL 값이 200 mg/kg이상이고, 독성 관련 특이 소견이 없음을 확인함
✓ 86종의 off-target에 대한 우수한 선택성을 확인함
✓ in vivo 효능 평가(Morris water-maze)를 통해 장기 투여시 효능을 검증함
✓ in vivo 효능 평가(passive avoidance)를 통해 낮은 용량으로 장기 투여시 효능을 검증함
✓ metabolite study를 통해 전임상시험

✓ in vivo 효능 및 안전성 평가를 위해 KDS2010 125g을 합성하였음
✓ 2주 반복독성 시험에서 NOAEL 값이 200 mg/kg이상이고, 독성 관련 특이 소견이 없음을 확인함
✓ 86종의 off-target에 대한 우수한 선택성을 확인함
✓ in vivo 효능 평가(Morris water-maze)를 통해 장기 투여시 효능을 검증함
✓ in vivo 효능 평가(passive avoidance)를 통해 낮은 용량으로 장기 투여시 효능을 검증함
✓ metabolite study를 통해 전임상시험에 적함한 profiling 결과를 얻음

( 출처: 보고서 요약서 3p )

Abstract ▼

4. Results
✓ 125g of KDS2010 was synthesized for in vivo tests and ADME/Tox tests
✓ In repeated toxicity test (2 weeks, rat), we found that NOAEL was more than 200 mg/kg and there was no significant toxicity.
✓ We confirmed that KDS2010 have excellent selectivities against 86 off-targets.

4. Results
✓ 125g of KDS2010 was synthesized for in vivo tests and ADME/Tox tests
✓ In repeated toxicity test (2 weeks, rat), we found that NOAEL was more than 200 mg/kg and there was no significant toxicity.
✓ We confirmed that KDS2010 have excellent selectivities against 86 off-targets.
✓ KDS2010 restores the cognitive impairment of APP/PS1 mice in both Morris water-maze and passive avoidance tests
✓ KDS2010 exhibited excellent profiles in metabolite study using rat, mouse, dog, monkey microsomes.

( 출처 : SUMMARY 5p )