초록

◆세부과제명: 동물용의약품등 중 화학제제 분석법 모니터링 및 개선
◦ 방역용 소독제를 대표하는 주요 성분의 분석법 개선 및 확립을 통한 품질관리 기술향상
- 복합4급암모늄, 산성제, 산화제, 글루타알데히드, 요오드등 기타제제
◦ 정책 건의 및 채택
-확립된 분석법의 「동물약품공정서」6개정에 반영
◦ 기술 보급
- “분석법편람” 발간을 통한 소독제 분석법 공유

(출처 : 연구결과 요약 2p)

Abstract ▼

Introduction
Chlorine dioxide (ClO2) is a yellow-green, water soluble gas with a boiling point of 11℃. It has been used as water and food sanitizer as an aqueous ClO2. ClO2 is known for a selective oxidant reacting mainly with organic materials that are highly reduced most chemical disinfectants

Introduction
Chlorine dioxide (ClO2) is a yellow-green, water soluble gas with a boiling point of 11℃. It has been used as water and food sanitizer as an aqueous ClO2. ClO2 is known for a selective oxidant reacting mainly with organic materials that are highly reduced most chemical disinfectants and thus is generally not as adversely affected by organic loads. Gaseous ClO2 had gotten attention by worth of its application against anthrax spore contaminations at bio-terror threat in USA. This study was aimed that gaseous ClO2 could be applied as fumigants at livestock farm alternative to formaldehyde or O-phenylphenol based fumigants. Therefore we revealed the best applying conditions for gaseous ClO2 in the poultry farm.

Materials & method
Chlorine dioxide (ClO2) gas was generated by ClO2 gas generating system (Purgo-farm.,Korea).
The chamber was produced as 0.72m3(L 1.2m, W 0.75m, H 0.8m). The chaff(n= 2) were used with exposure to 100mg/L of ClO2 for 1h, 2h and 24h respectively. The chaff were inoculated with avian influenza virus, H9N2(A/chicken/Korea/MS96/1996) mixed with 10% yeast extract solution or with hard water. Inoculated chaff were placed in sterile plastic box(L 8cm,W 12cm,H 7cm) with dry or with wet. The boxes were located at middle part of chamber. After appropriate contact time, the viable viruses in the chaff were detached by vortex for 10min into 100ml of 20% fetal bovine serum. The number of residual viable organisms were determined by HA test with embryonated eggs(10 day-old).

Results
We considered a log 4 reduction to be effective based on the international standard. The disinfection efficacy showed the difference depending on gas permeation by depth, organic load and humidity. Comparing the efficacy of ClO2 by depth of the chaff, the upper part(20g of chaff, 2.5cm depth) of the chaff showed 1.4 reduction at 1h, however it was effective against AIV after 24h, while middle and lower part of chaff were not affected by gaseous ClO2 regardless of exposure time. The gaseous ClO2 was more effective when the chaff was wet and without organic load.

Conclusion
This study revealed that ClO2 cannot be penetrated into porous matter deeply even though it is gas form. It is also affected by organic matter and humidity of disinfected surface. Therefore gaseous ClO2 should be applied after cleaning like liquid disinfectants do. Further experiments within controlled spaces are required in order to aid in the practical design of decontaminations in the field.

(출처 : 영문초록 31p)

목차 Contents

• 표지 ... 1
• 농림축산검역검사기술개발 연구과제 최종결과보고서 Final Report (FR) ... 2
• Ⅰ. 연구배경 및 목표 ... 3
• 1. 연구배경 ... 3
• 2. 연구최종목표 ... 4
• 3. 연차별 연구개발 목표 및 내용 ... 4
• Ⅱ. 연구방법 및 수행전략 ... 5
• 1. 재 료 ... 5
• 2. 연구전략 및 방법 ... 5
• Ⅲ. 연구결과 ... 6
• 1. 1차년도 연구결과(2013) ... 6
• 2. 2차년도 연구결과(2014) ... 13
• 3. 3차년도 연구결과 (2015) ... 15
• 5. 5차년도 연구결과 (2017) ... 19
• 5. 5차년도 연구결과 ... 24
• Ⅳ. 연구결과요약 ... 27
• 1. 1차년도 연구결과 ... 27
• 2. 2차년도 연구결과 ... 27
• 3. 3차년도 연구결과 ... 28
• 4. 4차년도 연구결과 요약 ... 28
• 5. 5차년도 연구결과 요약 ... 29
• Ⅴ. 고 찰 ... 29
• Ⅵ. 연구사업 추진상 문제점 및 건의사항 ... 30
• Ⅶ. 주요연구과제 변경사항 ... 30
• Ⅷ. 참고자료 ... 30
• IX. 영문초록 ... 30
• 끝페이지 ... 31