초록

본 과제는 한국인 피부모델 (전층, 표피, 색소화 모델)을 개발, 개선하였으며 일부 제한적인 실험 효능평가 연구로 그 활용성이 검증되었음. 이 시험법들을 활용하여 2개의 효능 원료를 도출하였으며 이중 1종은 기술이전되었음. 또한 한국인 피부세포주와 질환특성 세포주를 제작하여 3D 모델 구축 가능성을 확인하였음.

( 출처: 보고서 요약서 3p )

Abstract ▼

□ Purpose&Contents
○ To establish Korea-made 3D skin model using Korean skin cells for the development of functional cosmetic ingredients
○ To develop new alternative to animal test methods to address the evidence-based advertisement of cosmetic function claims
○ To develop multi-purpose te

□ Purpose&Contents
○ To establish Korea-made 3D skin model using Korean skin cells for the development of functional cosmetic ingredients
○ To develop new alternative to animal test methods to address the evidence-based advertisement of cosmetic function claims
○ To develop multi-purpose test methods using 3D skin model to address whitening, anti-aging, skin barrier function and investigate designer models to study special skin conditions.
○ To discover new functional targets for cosmetic ingredients using 3D model

□ Results
○ New test methods for the evaluation of whitening, anti-aging, barrier function tests were developed and with these methods, new whitening and anti-aging ingredients were developed.
○ New skin cell-lines were established including Korean-originated keratinocytes which can replace HaCaT.
○ New functional markers for skin barrier were suggested which can be used for the development of new methods.
○ For the study of special skin (like diseased skins), NRF2-KO keratinocyte cell line was established and with this cell, the manufacture of 3D model was investigated.
○ A new skin functional target, peroxiredoxin was discovered and verified through publication in a prestigious journal in dermatology (JID)

□ Expected Contribution
○ New evaluation methods for the development of cosmetics were established based on 3D skin models
○ The utility of 3D models was confirmed through discovering effective cosmetic ingredients (whitening, anti-aging), which will accelerate the study on cosmetics
○ The knowledge on skin physiology in relation to aging was advanced through using 3D skin models
○ The new 3D models would replace imported 3D models and promote the industry related

( 출처: SUMMARY 5p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• Contents ... 6
• 목차 ... 7
• 1. 연구개발과제의 개요 ... 8
• 1-1. 연구개발의 목적 ... 8
• 1-2. 연구개발의 필요성 ... 8
• 1-3. 연구개발 범위 ... 16
• 2. 국내외 기술개발 현황 ... 18
• 3. 연구수행 내용 및 결과 ... 22
• 4. 목표달성도 및 관련분야에의 기여도 ... 100
• 4-1. 목표달성도 ... 100
• 4-2 관련분야기여도 ... 102
• 5. 연구결과의 활용계획 ... 103
• 6. 연구과정에서 수집한 해외과학기술정보 ... 105
• 7. 연구개발성과의 보안등급 ... 107
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 107
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 107
• 10. 연구개발과제의 대표적 연구실적 ... 108
• 11. 기타사항 ... 108
• 12. 참고문헌 ... 109
• [별첨4] 실적 증빙자료 ... 110
• [별첨5] 사업성과 요약서 ... 143
• 끝페이지 ... 144