초록

외용 한약재를 활용하여 미세먼지로 인한 피부손상 후보 한약재 및 유효활성성분을 도출함.황기 등의 후보한약재는 미세먼지로 유도된 각질형성세포의 세포사 및 밀착연접단백질 손상을 억제하는 것으로 보임.

(출처 : 요약서 3p)

Abstract ▼

Purpose&Contents
Diesel Particulate Matter (Diesel Particulate Matter) is known to be the main source of pollution in the atmosphere. Therefore, in this project, we will investigate the mechanism of skin damage which can be caused by diesel dust, and to find out anti-pollution materials and extra

Purpose&Contents
Diesel Particulate Matter (Diesel Particulate Matter) is known to be the main source of pollution in the atmosphere. Therefore, in this project, we will investigate the mechanism of skin damage which can be caused by diesel dust, and to find out anti-pollution materials and extract active ingredients.

Many studies have been conducted on the effects of air pollutants such as fine dust on respiratory diseases and heart diseases. We have conducted this study in a situation where there is relatively little interest in skin and eye effects.
Experiment using Dong-bibogam (Oriental medicine) which is used as an external medicine.

Results
○ Evaluate the effects of harmful factors such as fine dust on the skin and identify the effects and mechanism of herbal medicines that can prevent / treat them. It was confirmed that oxidative stress in the treatment of high concentration of fine dust suppresses the proliferation of keratinocytes and promotes apoptosis. In addition, we confirmed that occludin, a tight junction protein responsible for skin barrier function, is damaged during fine dust treatment.

○ After evaluating the antioxidative anti-inflammatory efficacy of 62 kinds of medicinal herb extracts, candidate herbal medicines and active ingredients were derived. Hwanggi extract and formononetin are expected to inhibit the apoptosis of keratinocytes induced by diesel particulates and to treat skin damage through proliferation of keratinocytes.

○ Gardenia and its constituents (Geniposide, Chlorogenic acid, Gardenoside, Geniposidic acid, Genipin) protect the keratinocyte from oxidative stress induced by diesel particulate and prevent the loss of tight junction.

○ It is confirmed that Tribuli Fructus, Atractylodis Rhizoma Alba, Cimicifugae Rhizoma, Gleditsiae Semen, Scutellariae Radix, Cnidii Fructus, Cinnamomi Cortex Spissus can be used as a material to prevent oxidative stress and damage caused by fine dust treatment in cornea and conjunctiva of the external eye

Expected Contribution
○ It is anticipated that it will be possible to develop a new type of futuristic material that can cope with environmental diseases by using Korean medicine knowledge information.

○ By using research results developed through this project, we will conduct research on formulations and follow-up studies as external medicine to challenge the tasks such as drug development.

○ Analysis of the inhibitory effect of the candidate substance on the penetration of fine dust cells into the skin through Bio-TEM analysis.

○ While products that can protect skin from harmful environment are becoming a global trend, if you develop cosmetics that can effectively cope with various environmental factors such as ultraviolet ray, fine dust and ozone, and acquire intellectual property rights, And K-beauty craze overseas.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• CONTENTS ... 6
• 목차 ... 7
• 1. 연구개발과제의 개요 ... 8
• 1-1. 연구개발 목적 ... 8
• 1-2. 연구개발의 필요성 ... 8
• 2. 국내외 기술개발 현황 ... 11
• 3. 연구수행 내용 및 결과 ... 15
• 3-1. 연구내용 ... 15
• 3-2. 연구추진전략 및 방법 ... 16
• 3-3. 연구결과 ... 17
• 4. 목표달성도 및 관련분야 기여도 ... 34
• 4-1. 목표달성도 ... 34
• 4-2. 관련분야 기여도 ... 34
• 5. 연구결과의 활용계획 ... 35
• 6. 연구과정에서 수집한 해외과학기술정보 ... 36
• 7. 연구개발성과의 보안등급 ... 36
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 36
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 37
• 10. 연구개발과제의 대표적 연구실적 ... 39
• 11. 기타사항 ... 39
• 12. 참고문헌 ... 40
• 별첨4. 실적 증빙자료 ... 41
• 별첨5. 사업성과 요약서 ... 46
• 별첨6. 과제기본정보 서식 ... 47
• 끝페이지 ... 48