초록 ▼

◦ 목표: 한국베크만광의료기기연구센터는 의광학 분야의 세계적 연구기관인 Beckman Laser Institute와 공동연구로 확보한 핵심원천기술의 상용화를 앞당기고 산학연병 연구클러스터 조성과 전문 연구인력 양성을 통해 국내 광의료기기 산업선진화와 세계적인 광의료기기 연구센터로 도약하고자 함.
◦ 공동연구 실적: 2013년 4월 30일 단국대학교에 BLI-Korea 개소 후, 과학적 성과로 SCI 논문 61건(공동11건), 국내외 학술발표 174건, 기술적 성과로 해외 특허 출원/등록 5건/1건, 국내 특허 출원/등록 56건

◦ 목표: 한국베크만광의료기기연구센터는 의광학 분야의 세계적 연구기관인 Beckman Laser Institute와 공동연구로 확보한 핵심원천기술의 상용화를 앞당기고 산학연병 연구클러스터 조성과 전문 연구인력 양성을 통해 국내 광의료기기 산업선진화와 세계적인 광의료기기 연구센터로 도약하고자 함.
◦ 공동연구 실적: 2013년 4월 30일 단국대학교에 BLI-Korea 개소 후, 과학적 성과로 SCI 논문 61건(공동11건), 국내외 학술발표 174건, 기술적 성과로 해외 특허 출원/등록 5건/1건, 국내 특허 출원/등록 56건/27건, 시작품 4건, 시제품 3건, 경제적 성과로 기술이전 16건 실적을 산출함. 이를 통해 파생 과제 14건 총 71억원의 연구비 수주, ㈜인핏앤 컴퍼니, 원텍㈜에 기술이전을 통한 사업화에 성공함.
◦ 기관운영 실적: 지난 6년간 정부출연금 현금 34.7억, 해외기관의 대응자금 9.2억, 단국대학교 12억, 지자체 15억, 기업체 8.6억 통해 단국대학교 내 전용공간 723.3 ㎡에 광의료기기 연구기반 구축하였고, 전임교원 3명/연구교수 9명을 신규채용하여 참여하였고, BLI연구원 18명이 장기파견 연구를 수행하였고, 사회적 성과로 국제공동심포지엄 7회, 국내학술대회 13회, 국내/해외인력유치 76회/49회, 석박사 25명 인력배출의 실적을 산출함.

(출처 : 보고서 요약서 5p)

Abstract ▼

The purpose of the Beckman Laser Institute-Korea (BLI-Korea) at the Dankook University is to establish a world-leading institute in the biophotonic medicine by combining cutting-edge technologies of the Beckman Laser Institute (BLI) at the University of California Irvine (UCI) and ample experiences

The purpose of the Beckman Laser Institute-Korea (BLI-Korea) at the Dankook University is to establish a world-leading institute in the biophotonic medicine by combining cutting-edge technologies of the Beckman Laser Institute (BLI) at the University of California Irvine (UCI) and ample experiences in developing medical laser devices of Dankook Medical Laser Research Center (DMLRC).

Research projects in the BLI-Korea includes development of Diffuse Optical Spectroscopic Imaging (DOSI), Low Level Laser Therapy (LLLT), and Electromechanical Reshaping/Electrochemical Therapy (EMR/ECT). Three specific tasks have been conducted as follows:

■ First Task: DOSI (Diffuse Optical Spectroscopy & Imaging)
◦Phase 1:　Development of DOSI based breast cancer detection system as well as novel diagnostic technologies of head and neck thyroid cancer
- Achievement of the DOSI technology and its clinical applications for Korean
- Building and evaluating a prototype for breast cancer detection
- Designing a diagnostic probe for head and neck/thyroid cancer
◦Phase ２:　Development of a clinically-friendly DOSI system for cancer diagnosis and study on 3D multi-functional high-resolution Optical Coherence Tomography
- Developing a compact multiple laser diode combiner with a single output
- Designing the homodyne-based signal processing technique for the clinically-friendly DOSI
- Developing the clinically-friendly DOSI prototype and transfer its technologies to a domestic company (Infit & Co.) for the commercialization
- Building and optimizing the 3D Optical Coherence Tomography for the diagnosis of oral cancer

■ Second Task: LLLT (Low Level Laser Therapy)
◦Phase 1:　To develop medical equipment of the LLLT for inner ear disorders including hearing loss, dizziness, and tinnitus
- LLLT system development for clinical studies of the inner ear disorders
- Advancement of the animal study based gap prepulse inhibition of acoustic startle(GPIAS) method for diagnosis of human tinnitus
◦Phase 2:　Broadening the scope of the clinical studies for the damaged taste and auditory cells treatments.
- Succeed to commercialize the LLLT-based tinnitus treatment device (TINI^TM) by technology transfer to WONTECH
- Establish a model to analyze degenerative changes of taste cells
- Development of a prototype for the treatment to the hearing damage.

■ Third Task: EMR/ECT (Electromechanical Reshaping/Electrochemical Therapy)
◦Phase 1: Development of medical equipment for cosmetic cartilage surgery using the EMR technology
- Improvement of minimal invasive surgery techniques for auricular cartilages
- Building and evaluating a prototype for cosmetic cartilage surgery
◦Phase 2: Development of current control-based cartilage reshaping device (C2EMR) for pain control and evaluation of ECT-based skin tissue control and adipose tissue change
- Improvement of the EMR device to mitigate the pain by controlling the applied current to auricular cartilages
- Evaluating and acquiring the KTL approval for the C2EMR performance for cosmetic cartilage surgery
- Studying on the ECT-based skin tissue control and adipose tissue change

■ Misc. Task: TPM (Two Photon Microscopy)
◦Phase 1: Developing a measurement tool for a melanocyte activity and distribution as well as its clinical application
- Optimization of the TMP system for imaging melanocytes in epidermis
- Acquiring melanocyte images using the TMP and quantitative image analysis
※ The developed TPM system during phase 1 could not only elucidate fundamental mechanisms of therapeutics for skin pigment disorders but also acquire images of melanocytic tumors in skin. Therefore, in order to localize TPM technology, it was derived as a new project by the Ministry of Trade, Industry and Energy.

These systems and technologies have been successfully developed at the BLI-Korea in close collaboration with the BLI at the UCI for last six years. The BLI-Korea has applied to the DOSI system for diagnosis of breast cancers/head and neck tumors for Korean as well as asian patients. These clinical results using the system will be used for our international collaborative project of breast cancer research. In addition, developments of the novel LLLT and EMR techniques will be utilized for next generation medical equipment for examination of inner ear diseases and cosmetic cartilage surgery, respectively.

In particular, BLI-Korea has achieved the commercialization of two medical devices by transferring technologies to domestic companies. One is the homodyne-based DOSI technology. Based on DOSI technology, Infit&Co., which is a spin-off company from LG, attracted the 3.5 billion investment at the Series-A level. The other is LLLT-based therapeutic device. WONTECH succeed to commercialize the LLLT-based tinnitus treatment device (TINI^TM) by technology transfer from BLI-Korea.

Through visiting research and training programs with the BLI, eighteen researchers from UCI have been visited in the BLI-Korea and actively involved in the development of the DOSI, LLLT and EMR/ECT for six years. Moreover, the BLI-Korea held seven international conferences, thirteen domestic conferences, and thirty video-conferences which promoted sharing ideas between researchers in the optics and engineering fields and participating them to active research in translational biomedical optics.

The BLI-Korea is a 723.3 ㎡ facility housed in the school of medicine at the Dankook University and affiliated with the graduate program (twenty five students received MS or PhD degree during six years) emphasized on the biophotonics medicine. The Dankook University hospital has provided financial supports of 200,000,000 Won and conducted clinical studies using the developed biophotonics systems after approval of the institutional review board (IRB). Furthermore, four domestic companies has supports 660,000,000 Won to the BLI-Korea for commercialization of developed biophotonics equipment as well as international seminars and research collaboration. Through the cross-interactions between academic institutions and industry, the BLI-Korea continues concentrating the development of state-of-the-art biophotonic systems for early diagnosis and treatment of human diseases as well as leveraging the new technologies that will drive enhancement of current medical equipment and devices.

(출처 : SUMMARY 11p)

목차 Contents

• 표지 ... 1제 출 문 ... 2보고서 요약서 ... 4요 약 문 ... 6S U M M A R Y ... 11C O N T E N T S ... 14목차 ... 15제 1 장 연 구 개 발 ... 16 제 1 절 : 연구개발의 목적 및 필요성 ... 16 제 2 절 : 국내외 기술개발 현황 ... 21 제 3 절 : 연구개발 내용 및 결과 ... 26 제 4 절 : 연구개발 목표달성도 및 관련분야에의 기여도 ... 99 제 5 절 : 연구개발결과의 활용 계획 ... 102제 2 장 기관유치 및 운영 ... 105 제 1 절 : 해외연구기관 유치 목적 및 필요성 ... 105 제 2 절 : 공동연구센터 운영 현황 ... 107 제 3 절 : 해외연구기관의 협력 성과 ... 112 제 4 절 : 해외연구기관 유치 노력 및 성과 ... 137 제 5 절 : 공동연구센터 자립 및 활용계획 ... 145제 3 장 기타 사항 ... 148 제 1 절 : 사업추진과정에서 수집한 해외과학기술정보 ... 148 제 2 절 : 연구시설‧장비 현황 ... 149 제 3 절 : 기타 사업성과 ... 151 제 4 절 : 참고문헌 ... 154[붙임 1] 해외우수연구기관유치사업 연차별 목표 및 달성도 현황 ... 156[붙임 2] 해외우수연구기관유치사업 예산 확보 및 사용 실적 ... 164[붙임 3] 해외우수연구기관유치사업 대표 성과 및 연구성과 보고서 ... 170[붙임 4] 연구기관 설치승인 통보서 ... 223[붙임 5] 한국베크만광의료기기연구센터 규정 ... 224끝페이지 ... 228