초록

전 세부에 걸쳐 미토콘드리아 유발 활성산소, CBR1, Ghrelin에 관하여 심도 있는 연구를 진행하였음. 미토콘드리아에서 유발되는 활성산소는 근육의 분화, 염증성 장질환 등에서 조절을 하고 있음을 밝힘. CBR1은 유방암, 혈액암 등 다양한 암에서 그 발현이 높아 항암제의 효율을 저해하는 것을 밝혔으며, 그 역할이 근분화 과정에도 영향을 미치고 있음을 보여주었음. Ghrelin은 당독성으로 인해 유발되는 뇌신경 손상으로부터 신경세포를 보호하는 새로운 기전을 밝혔음.

(출처 : 보고서 요약서 3p)

Abstract ▼

□ Purpose
Regulatory mechanisms for oxidative stress and their relevance with diverse diseases
▣ 1st step
① Studies on the regulatory mechanisms for antioxidant proteins and antioxidative signaling networks
② Studies on the regulatory mechanisms for redox balance and energy homeostasi

□ Purpose
Regulatory mechanisms for oxidative stress and their relevance with diverse diseases
▣ 1st step
① Studies on the regulatory mechanisms for antioxidant proteins and antioxidative signaling networks
② Studies on the regulatory mechanisms for redox balance and energy homeostasis under oxidative stress
③ Investigation of the role of oxidative stress in the regulation of sleep-wake cycle
④ Construction of database for oxidative stress genes and association analysis of them with diseases and health indexes
▣ 2nd step
① Investigation of expression and functional abnormality of antioxidant proteins and its relevance with oxidative stress-related diseases
② Identification of novel regulators for redox balance and energy homeostasis and its relevance with metabolic diseases and cancer
③ Investigation of the mechanism of oxidative stress-induced sleep disorder
④ Investigation of underlying mechanisms for the vascular injury induced by the oxidative stress as the cause of ROS-related cardiovascular diseases

□ Contents
1. Identification of factors effectively regulating oxidative stress and their functional study
1) Mechanism study for expression and functional abnormality of antioxidant proteins under oxidative stress
① Study on expression and function of antioxidant proteins and their roles on oxidative stress-induced damage
② Identification of novel antioxidant proteins that depend on Nrf2, HIFs, and ATF6 and their antioxidative signaling networks
③ Study on expression and functional abnormality of antioxidant proteins under chronic oxidative stress
④ Relevance of novel antioxidant proteins with oxidative stress-related diseases cancer and metabolic disease
2) Mechanism study for redox balance and energy homeostasis under oxidative stress
① Effect of oxidative stress on cellular parameters for redox balance and energy homeostasis
② Signal transduction pathways among AMPK, and SIRT1
③ Identification of novel regulatory proteins for AMPK and SIRT1
④ Relevance of novel regulators with metabolic disease and cancer

2. Mechanism of oxidative stress-related disorders
1) Mechanism study for sleep disorder as an oxidative stress-related brain disease
① Expression change of nNOS & iNOS in sleep-wake related neurons in sleep disorder
② Change in oxidative stress response in sleep-wake related neurons in sleep disorder
③ Expression change of antioxidant enzymes & proteins in sleep-wake related neurons in sleep disorder
④ Effect of nitric oxide on electrical activity of sleep-wake related neurons in sleep disorder
2) Genomic study for the underlying mechanisms of oxidative stress-induced vascular injury
① Construction of database for the oxidative stress genes
② Discovery of genetic variations in oxidative stress genes and investigation of their association with diseases and health indexes using GWAS data
③ Pathophysiological investigation of vascular injury induced by the oxidative stress through the genetic approach
④ Genomic and proteomic approach of underlying mechanisms for the vascular injury induced by the oxidative stress

□ Development results
1. Development of result
1) Published 152 papers until August, 2018 (SCI; 137)
2) Attend the various conference for present our results
2. Human infrastructure
1) Master ; 38
2) Ph.D ; 28

□ Expected Contribution
① Scientific : elucidating the mechanisms of ROS in human body and becoming a world-leading research center in the field of oxidative stress
② Economic : developing research products to patents and commercialization
③ Educational : training graduate students to become leading biomedical scientists
④ Human health : providing important knowledges to the development of treatment methods for oxidative stress-related disorders

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• Ⅰ 개요 ... 7
• 1. 목표 ... 7
• 2. 주요연혁 ... 9
• 3. 사업개요 ... 9
• 4. 조직 ... 12
• 5. 인력 현황 ... 14
• 6. 연구비 집행현황 ... 19
• Ⅱ 연구성과 ... 20
• 1. 연구성과 요약 ... 20
• 2. 사업수행 산출성과 ... 22
• 3. 기타 주요업적 ... 66
• Ⅲ 사업관리 및 기반구축 ... 68
• 1. 사업관리 ... 68
• 2. 설치대학의 지원실적 ... 68
• 3. 연구시설 기반구축 ... 69
• Ⅳ 목표달성도 ... 71
• 1. 목표달성도 ... 71
• 2. 대표 연구업적 ... 73
• 3. 센터 향후 연구계획 ... 76
• Ⅴ (NCRC만 작성)중·대분야간 융합분야 대학원 교육시스템 ... 77
• 1. 중·대분야간 융합분야 대학원 교육시스템 구축 ... 77
• 2. 중·대분야간 융합기술 전문연구인력 양성 실적 ... 79
• 3. 기타 인력양성 프로그램 수행 실적 ... 80
• 첨부 ... 82
• 끝페이지 ... 99