초록 ▼

제1총괄과제에서는 면역유래물질에 의한 마우스의 운동학습 영향을 평가하고, STIM1단백질에 의한 신경생리학적 변화를 분석하였으며, 기억형성 관련한 질환동물에서 기억형성 기전에 대한 분석을 하였음. 또한 알츠하이머 동물모델에서 microglia의 활성화에 대한 다양한 생리적 변화에 대한 기전을 연구하였음.
제2총괄과제에서는 microglia의 활성에 관여하는 STAT3 신호전달의 기전을 확인하고, 면역 및 염증반응 제어에 따른 항우울 반응을 분석하였음. 또한 차세대 proteomics 기술을 활용하여 microglia활성화에 대

제1총괄과제에서는 면역유래물질에 의한 마우스의 운동학습 영향을 평가하고, STIM1단백질에 의한 신경생리학적 변화를 분석하였으며, 기억형성 관련한 질환동물에서 기억형성 기전에 대한 분석을 하였음. 또한 알츠하이머 동물모델에서 microglia의 활성화에 대한 다양한 생리적 변화에 대한 기전을 연구하였음.
제2총괄과제에서는 microglia의 활성에 관여하는 STAT3 신호전달의 기전을 확인하고, 면역 및 염증반응 제어에 따른 항우울 반응을 분석하였음. 또한 차세대 proteomics 기술을 활용하여 microglia활성화에 대한 신경-면역 네트워크 모델을 검증하고, 연관 표적 단백질 및 질병표지자를 발굴하였으며, 면역제어를 위한 Substance A에 대한 항체를 선별하고, IL-2항체를 발굴하였음.

(출처 : 보고서 요약서 3p)

Abstract ▼

□ Purpose
Goal: To define the mechanism by which memory is stored in neuro-immune network and to develop the original technology for improving memory formation modulation and memory disorder diseases.
Specific aims: (1) Understanding the mechanism by which cytokines modulate neurons and memor

□ Purpose
Goal: To define the mechanism by which memory is stored in neuro-immune network and to develop the original technology for improving memory formation modulation and memory disorder diseases.
Specific aims: (1) Understanding the mechanism by which cytokines modulate neurons and memory related neural circuits, (2) Investigating the neuro-immune interaction via neuron-secreted disease factors, (3) Identifying the targets and markers of memory disorder diseases via the use of Omics, (4) Development of original technology for the amelioration and modulation of memory through specific modulation of the activation of brain immunocytes

□ Contents
Division-1 focuses on understanding the neuro-immune interaction by investigating the modulating mechanism of the neuro-immune information-storage network. Division-2 aims to develop original technology for modulation by discovering targets and markers of memory disorder diseases and memory, then verifying their usefulness together with division-1.
Division-1: Research on neuro-immune interaction driven memory formation networks
In the neuro-immune system of the brain, section1 will cover the neural systems and section 2 the immune systems, resulting in research of the neuro-immune interaction. Specifically, 1) Discovering the mechanism by which astrocyte of microglia (immunocytes of the brain) secreted molecules modulate the excitability, cell organelles and gene expression, 2) Defining the physiological mechanism by which synaptic propagation, plasticity and memory is modulated, 3) Understanding the immunological mechanism of the cause of memory disorder diseases by studying gene expression of Alzheimer model animals through transcriptome analysis and analysis cytokine excretion modifications by beta-amyloids.
Division-2: Discovering the Targets and Markers of memory disorder diseases and Researching the control of neuro-immune networks
Section 1 focuses on developing specific control technology via the activation of brain immunocytes, and section 2 focuses on discovering markers and targets. Specifically, 1) Establish PTM proteomics technology in neurons and brain immunocytes (microglia and astrocytes), 2) Discovering the mechanism, early markers and modulators in memory disorder animal models through both qualitative and quantitative proteomics, 3) Researching the control of immune system activation and modulation of memory deficiency through the development of single-domain and target antibodies specific to the activation mechanism. This will be achieved via the use of transgenic animals expressing specific mutations in neural microglia and astrocytes.

□ Development results
Division-1 evaluated the effect of immune-derived substance on exercise learning, analysed the pathophysiological changes induced by STIM1 proteins, and investigated the mechanism of memory formation in the animal model of memory disorder. Division-1 also studied the physiological changes induced by microglia activation in the animal model of Alzheimer.
Division-2 investigated the signaling mechanism of STAT3 in microglia activation, discovered anti-depressant effect by immune modulation. Division-2 also evaluated neuro-immune network model in response to microglia activation by next-generation proteomics and discovered target proteins and markers of the disease.

□ Expected Contribution
This center will apply information obtained in neuroscience to immunology and set an example of overcoming the neuro-immune limitation. Moreover, result of this center will lead immunologic approach in development of diagnosis and treatment of Alzheimer and brain tumor. Ultimately, the aim is to establish a much desired hub for students aspiring to become medical scientists.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• Ⅰ 개요 ... 7
• 1. 목표 ... 7
• 2. 주요연혁 ... 10
• 3. 사업개요 ... 12
• 4. 조직 ... 15
• 5. 인력 현황 ... 16
• 6. 연구비 집행현황 ... 19
• Ⅱ 연구성과 ... 20
• 1. 연구성과 요약 ... 20
• 2. 사업수행 산출성과 ... 35
• 3. 기타 주요업적 ... 96
• Ⅲ 사업관리 및 기반구축 ... 97
• 1. 사업관리 ... 97
• 2. 설치대학의 지원실적 ... 98
• 3. 연구시설 기반구축 ... 101
• Ⅳ 목표달성도 ... 102
• 1. 목표달성도 ... 102
• 2. 대표 연구업적 ... 114
• 3. 센터 향후 연구계획 ... 118
• 첨부 ... 119
• 끝페이지 ... 141