초록

본 연구는 융합 유전체 정보를 이용해 위암의 새로운 분류를 시도하였고, 위암 면역치료제 및 혈관생성 억제제 전향적 임상연구 기 확보하였음. 위암의 새로운 유전체 분류 및 면역, 혈관 시그니처 발굴에 성공하였음. 발굴한 시그니쳐를 여러 데이터에서 검증하였고, 시제품을 제작하여 테스트 중에 있음.

(출처 : 요약서 3p)

Abstract ▼

Purpose&Contents
Precision medicine through development of companion diagnostics predictive of treatment response to immunotherapy and antiangiogenic agent based on gene expression signature in patients with advanced gastric cancer

Results
1. Application and evaluation of biomarker to t

Purpose&Contents
Precision medicine through development of companion diagnostics predictive of treatment response to immunotherapy and antiangiogenic agent based on gene expression signature in patients with advanced gastric cancer

Results
1. Application and evaluation of biomarker to the prospective clinical trials
2. Verification of gene expression signature biomarker by comparing the results of clinical trials
3. Revalidation of gene expression signature biomarker and kit production

< Sub-project 1>
○ Conducting prospective clinical trials of immunotherapeutic and antiangiogenic agents in advanced gastric cancer
○ Establishment of comprehensive database comprising of patients information and specimens in parallel with clinical trials
○ Validation of immune signature and angiogenic signature through prospective clinical trials
○ Discovery of clinical and pathologic biomarkers which are predictive of therapeutic response

< Sub-project 2>
○ Multiomics data production _ based on Nanostring
○ Validation of immune and angiogenic signature which are discovered through bioinformatic analysis
○ Functional study of newly excavated genes related to immune and angiogenesis
○ Patient-derived cell (PDC) establishment and validation of our results using PDC

Expected Contribution
○ Provision of basic materials for realization of precision medicine in advanced gastric cancer
○ Promotion of new immunotherapeutic and antiangiogenic agents based on gene expression signature of this study
○ Widely utilized for screening patients in a clinical trial of immunotherapeutic and antiangiogenic agents in a variety of cancers
○ Utilized as screening tools for proper therapy of immunotherapeutic and angiangiogenic agents in gastric cancer
○ Creating a synergy effect with personalized cancer care clinic
○ Attempts of extensive clinical application through development prototype.
○ Panel manufacturing and supply agreement of our results with companies

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• 1. 연구개발과제의 개요 ... 7
• 1-1. 연구개발 목적 ... 7
• 1-2. 연구개발의 필요성 ... 7
• 1-3. 연구개발 범위 ... 7
• 2. 국내외 기술개발 현황 ... 8
• 3. 연구수행 내용 및 결과 ... 11
• 4. 목표달성도 및 관련분야 기여도 ... 50
• 4-1. 목표달성도 ... 50
• 4-2. 관련분야 기여도 ... 51
• 5. 연구결과의 활용계획 ... 53
• 6. 연구과정에서 수집한 해외과학기술정보 ... 56
• 7. 연구개발성과의 보안등급 ... 56
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 57
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 58
• 10. 연구개발과제의 대표적 연구실적 ... 60
• 11. 기타사항 ... 61
• 12. 참고문헌 ... 63
• [별첨4]임상‧오믹스 정보생산 실적서 ... 65
• [별첨5]실적 증빙자료 ... 67
• 끝페이지 ... 134