![Citalopram accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of citalopram (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against citalopram concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM](https://nrms.kisti.re.kr/bitextimages/TRKO202100000641/TRKO202100000641_8_image_6.png "Citalopram accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of citalopram (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against citalopram concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM")
![Paroxetine accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of paroxetine (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against paroxetine concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM](https://nrms.kisti.re.kr/bitextimages/TRKO202100000641/TRKO202100000641_11_image_1.png "Paroxetine accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of paroxetine (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against paroxetine concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM")
![Sertraline accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of sertraline (3, 10, and 30 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered sertraline-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against sertraline concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM](https://nrms.kisti.re.kr/bitextimages/TRKO202100000641/TRKO202100000641_13_image_1.png "Sertraline accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of sertraline (3, 10, and 30 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered sertraline-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against sertraline concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM")
![Trazodone accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of trazodone (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered trazodone-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against trazodone concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM](https://nrms.kisti.re.kr/bitextimages/TRKO202100000641/TRKO202100000641_15_image_19.png "Trazodone accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of trazodone (10, 30, and 100 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered trazodone-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against trazodone concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM")
![Vilazodone accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of paroxetine (3, 10, and 30 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against vilazodone concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM](https://nrms.kisti.re.kr/bitextimages/TRKO202100000641/TRKO202100000641_17_image_23.png "Vilazodone accelerates the decay of Kv3.1 current. (A) Kv3.1 currents were elicited by +40 mV pulses from a holding potential of -80 mV every 10 s. Traces recorded in the presence of paroxetine (3, 10, and 30 mM) were superimposed. The solid lines and dotted line represent double exponential fits and the zero current, respectively. (B) In the double exponential fits in (A), the fast component (with a time constant tD) was considered paroxetine-induced decay of Kv3.1 current because the slow component represents intrinsic channel inactivation. The inverse of tD obtained at +40 mV was plotted against vilazodone concentrations. The solid line represents the least-squares fit of the data with the equation 1/tD = k+1[D] + k-1. The binding (k+1) and unbinding (k-1) rate constants were obtained from the slope and y-intercept of the fitted line. Data are expressed as means ± SEM")
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| 주관연구기관 | 전북대학교 Chonbuk National University |
|---|---|
| 연구책임자 | 최복희 |
| 보고서유형 | 최종보고서 |
| 발행국가 | 대한민국 |
| 언어 | 한국어 |
| 발행년월 | 2020-04 |
| 과제시작연도 | 2019 |
| 주관부처 | 과학기술정보통신부 Ministry of Science and ICT |
| 등록번호 | TRKO202100000641 |
| 과제고유번호 | 1711083571 |
| 사업명 | 개인기초연구(과기정통부)(R&D) |
| DB 구축일자 | 2021-06-05 |
| 키워드 | 간질.항경련제.칼륨이온통로.항우울제. |
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