보고서 정보
주관연구기관 |
한국원자력연구원 Korea Atomic Energy Research Institute |
연구책임자 |
박상현
|
참여연구자 |
박성주
,
박태진
,
장범수
,
최대성
,
이동은
,
노종국
,
이주상
,
최미희
,
강정애
,
윤선혜
,
손민주
,
우타미
,
홍승헌
,
최병민
,
배기상
,
최선복
,
김대승
,
전용덕
,
한요한
,
임석희
,
김동관
,
조일주
,
김동구
,
신준연
,
염유선
,
김주연
,
장솔아
,
김나경
,
황영묵
,
신우호
,
이상복
|
보고서유형 | 1단계보고서 |
발행국가 | 대한민국 |
언어 |
한국어
|
발행년월 | 2014-10 |
과제시작연도 |
2013 |
주관부처 |
미래창조과학부 Ministry of Science, ICT and Future Planning |
과제관리전문기관 |
한국연구재단 National Research Foundation of Korea |
등록번호 |
TRKO202100004426 |
과제고유번호 |
1711002610 |
사업명 |
원자력연구기반확충사업 |
DB 구축일자 |
2021-07-10
|
키워드 |
RI-Biomics 기술.방사성동위원소.바이오마커.소화기 질환.췌장질환.대장질환.정보시스템.인력양성.분자영상.RI-Biomics technology.Radioisotope.Bio-marker.Gastrointestinal diseases.Pancreatic diseases.Colon diseases.Information system.Man-power training.Molecular imaging.
|
초록
▼
RI-Biomics기술의 실시간 시현, 고감도 검출의 RI 특성을 활용한 진단 영상화를 위한 기술 개발 및 정보시스템을 구축하여 소화기 질환의 진단과 예측 시스템을 연구하고, 이에 따라 RI를 전문적으로 취급하고 연구에 사용하는 전문인력 양성
● 생물 분자의 방사성동위원소 표지조건 확립
● 급성췌장염 조절 단일물질의 RI 표지기술 개발
● 궤양성 대장질환 바이오마커의 RI 표지기술 개발
● RI-표지체의 표적특이성 및 안정성 평가
● 급/만성췌장염의 진단 및 조절을 위한 RI기반 bio-sensing 기술
RI-Biomics기술의 실시간 시현, 고감도 검출의 RI 특성을 활용한 진단 영상화를 위한 기술 개발 및 정보시스템을 구축하여 소화기 질환의 진단과 예측 시스템을 연구하고, 이에 따라 RI를 전문적으로 취급하고 연구에 사용하는 전문인력 양성
● 생물 분자의 방사성동위원소 표지조건 확립
● 급성췌장염 조절 단일물질의 RI 표지기술 개발
● 궤양성 대장질환 바이오마커의 RI 표지기술 개발
● RI-표지체의 표적특이성 및 안정성 평가
● 급/만성췌장염의 진단 및 조절을 위한 RI기반 bio-sensing 기술 개발
● 궤양성대장염의 진단 및 조절을 위한 RI기반 bio-sensing 기술 개발
● RI-Biomics 기술 전문인력양성 프로그램 현황 분석 및 모델정립, 커리큘럼 개발
● RI-Biomics 기술정보시스템 구축
● RI-Biomics 기술정보 분석 및 활용
(출처 : 보고서 요약서 3p)
Abstract
▼
Ⅳ. Results
1. Analysis of radioisotope labeling conditions of biological molecules.
○ Establishment of conditions of RI labeled biomolecules
- Manufacture of Tc-99m tricarbonyl precursor and establishment of radio-labeling method
- Manufacture of RI labeled BFCA for molecular imaging
Ⅳ. Results
1. Analysis of radioisotope labeling conditions of biological molecules.
○ Establishment of conditions of RI labeled biomolecules
- Manufacture of Tc-99m tricarbonyl precursor and establishment of radio-labeling method
- Manufacture of RI labeled BFCA for molecular imaging
○ Establishment of at least 95% of radiochemical purity of RI-labeled material
2. Development of RI-labeling techniques of acute pancreatitis controlled substance
○ Development of RI-labeling techniques for molecular imaging of single substance
3. Development of RI labeling techniques of biomarkers for colon diseases
○ Development of RI-labeling techniques for molecular imaging of bio-marker
4. Evaluation of target specificity and stability for RI labeled substance
○ RI-labeling of single substance of gastrointestinal diseases and evaluation of its molecular imaging
○ RI-labeling of hyaluronic acid (HA) and evaluation of its molecular imaging
5. Development of bio-sensing technology treating pancreatitis
○ Suggest rutin, and hyaluronic acid which could treat AP and be labeld with RI
○ Confirmation of specificity and effectiveness of RI labelled single compound
6. Development of bio-sensing technology treating colon diseases
○ Suggest IL-6 which represents colon diseases
○ Establischment of method to label the RI with bio-marker protein
7. Analysis of the current situations for programs for training the professional manpower in the field of RI-Biomics and model design for the training
- Analysis of the current situations for the educational programs in RI-Biomics and its curriculums in Korea and oversea
· Investigation and analysis of the training programs by field, training course, and educational nation (or institute), that is, 10 nations and 23 training courses in RI field, 4 institutes and 11 educational institute in bio field, and 4 institutes and 4 educational courses in other fields
- Analysis of the needs for the education users through the demanding investigation for training the manpower in RI-Biomics
· Do detailed interview of experts for 7 fields, that is, nuclear medicine, radiopharmacy and development of new drugs, nuclear engineering, development of new drug, nonclinical test and pharmacokinetics, agricultural chemicals and RI labelling, microdosing and RI labelling)
· Investigation of education demand for related institutes in RI-Biomics and 11 research institutes in pharmaceutical companies in Korea
- Derivation of implications by analysis of the current situations
- Model design for training the manpower through analyzing ADDIE model
8. Preliminary investigation of educational curriculums for RI-Biomics
- Design of the question investigation for related departments by university and the things investigated
- Question investigation for 400 students in 16 universities (or graduate schools). Their majors are pharmacy, radiation, biology and chemistry.
9. Development of the curriculums for educational training in the field of RI-Biomics
- Development of detailed curriculums based on RI-Biomics
· Consisted with general handling for RI, manufacturing radioactive materials, radio pharmacokinetics, radiation imaging analysis
10. Demonstration operation of the training programs for RI-Biomics
- The demonstration operation, which has been performed for five times and 35 students been completed, of the training programs of the manapower in RI-Biomics and analysis of its results
· 3 training courses for student internship (10 persons finished), a training course for the experts (6 persons finished) and a special technical course (19 persons finished)
11. Collection of technology and information for constructing the system for supporting technology and information
- Periodic collection of the oversea recent news and information in RI-Biomics through the agreement for use of information provided in GTB of KISTI in Korea (20 to 30 information collected by day)
- Collection of about 700 technology and information of RI-Biomics. That is, 73 papers, 332 news, 80 trend analyzing information, 72 reports, 12 studies and 62 patents
12. Construction of the system for technology and information for RI-Biomics
- Analysis of the needs for the users, that are students of the related departments, enterprisers, researchers and the persons concerned with government, for technology and information through the question investigation
- Formation of the standard classifying structure for technology and information of RI-Biomics by taking consultation from the experts affiliated in the Commission for consulting technology and information. 5 large classifications and 20 medium ones (5 large classifications including biomedical science and development of new drugs, 20 detailed classifications including radiation biology and radiochemistry)
- Analyses of advantages and disadvantages through the comparison of operation type and operational process of BRIC, KOSEN, BIOIN and NNPC in Korea, and their characteristics
- Model design of the system for supporting technology and information by considering the question investigation and the expert consultations, and development of the program for its construction and operation
13. Analysis and application of technology and information in RI-Biomics
- The publication of issue paper, which is analyzed for the recent issues for RI-Biomics as the in-depth analyzing report for the trend in science and technology, is in process (3 Korean versions and 1 English one published)
- Publication and distribution of brochures for introducing and publicizing RI-Biomics for the public members (15 nations, 3,500 persons distributed)
- Publication of the analysis report for the current situations for training programs of the manpower in Korea and oversea, and the report for technology and information based on the recent trend analysis of technology and information (2 reports published)
- 3 technology mediations and 5 technology instructions for supporting the difficulties in the use of RI-Biomics center or of the necessities in research in the medium and small industries
- Investigation of the educational situations for training programs of the manpower in Korea and oversea and information communication. Holding 4 events of the training and technical workshop for analyzing the recent trend and collecting information of RI-Biomics
- Construction of the oversea network for RI-Biomics through the international meeting and information communication (Combined with 8th ICI)
- Operation of two booths for researches and technical publicity of RI-Biomics center in 8th ICI and International Nuclear and Radiation Expo
(출처 : SUMMARY 16p)
목차 Contents
- 표지 ... 1
- 제 출 문 ... 2
- 보고서 요약서 ... 3
- 요약문 ... 4
- SUMMARY ... 13
- CONTENTS ... 21
- 목차 ... 22
- 제1장 연구개발과제의 개요 ... 23
- 1. 연구개발의 목적 ... 23
- 2. 최종 연구개발 목표 ... 24
- 3. 연차별 연구개발 목표 및 내용 ... 25
- 4. 연구개발의 필요성 ... 27
- 제2장 국내외 기술개발 현황 ... 35
- 1. 국외 기술개발 현황 ... 35
- 2. 국내 기술개발 현황 ... 47
- 3. 국내외 기술개발 현황에서 차지하는 위치 ... 50
- 제3장 연구개발수행 내용 및 결과 ... 53
- 제1절 RI-Biomics기술 기반 영상화 기술 개발 ... 53
- 제2절 소화기 질환 관련 RI기반 Bio-sensing 신기술 개발 ... 117
- 제3절 RI-Biomics 인력양성 프로그램 개발 및 분석 ... 140
- 제4절 RI-Biomics 기술정보시스템 구축 ... 180
- 제5절 RI-Biomics 기술정보 분석 및 활용 ... 273
- 제4장 목표달성도 및 관련분야에의 기여도 ... 288
- 1. 연도별 연구목표 및 연구개발목표의 달성도 ... 288
- 2. 관련분야에의 기여도 ... 291
- 제5장 연구개발결과의 활용계획 ... 296
- 1. 추가연구의 필요성 ... 296
- 2. 타 연구에의 응용 ... 297
- 3. 활용방안 ... 300
- 4. 기업화 추진방안 ... 302
- 제6장 연구개발과정에서 수집한 해외과학기술정보 ... 303
- 1. 분자영상 ... 303
- 2. 소화기 질환 ... 311
- 제7장 참고문헌 ... 316
- 끝페이지 ... 322
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