초록

뇌종양 치료에 핵심요건인 혈액뇌장벽 투과성과 지속성을 얻기 위하여 (1) “뇌종양 표적지향성 약물전달시스템”과 (2)“체내 지속형 나노입자” 라는 두 가지 제제기술을 사용하는 약물전달 시스템 개발하고, 이를 이용하여 혈액뇌장벽 투과성이 낮은 항암 화학약물과 아폽토시스 유발 항암단백질을 효율적으로 뇌종양에 적용시키는 새로운 기전/개념의 뇌종양 치료요법을 완성하였음.

(출처 : 요약서 3p)

Abstract ▼

Purpose&Contents
The purpose of this study is to develop a novel drug delivery system (DDS) using two key technologies of (1) brain-targeting DDS and (2) prolonged nanaoparticles, and to improve the efficiency of system that deliver anti-tumor chemotherapeutics and anti-apoptotic proteins to brai

Purpose&Contents
The purpose of this study is to develop a novel drug delivery system (DDS) using two key technologies of (1) brain-targeting DDS and (2) prolonged nanaoparticles, and to improve the efficiency of system that deliver anti-tumor chemotherapeutics and anti-apoptotic proteins to brain glioma through blood-brain barrier (BBB).

Results
In order to attain this final aims, we designated two key research scopes, i.e., (1) a basic study for developing target-specific dual system and (2) an evaluation study for anti-tumor efficacy to brain glioma.
○ Basic study for the development of aimed preparations
- Optimization of human serum albumin (HSA) and PLGA polymers modified with target-specific ligands
- Design and evaluation of HSA nanoparticles modified with target-specific ligands
- Optimization study for HSA modified with target-specific ligands
- Optimization study for PLGA nanoparticles modified with target-specific ligands
○ Evaluation study for potency and efficacy
- Evaluation of anti-tumor potential of DDS modified with target-specific ligands
- Evaluation of permeability potential of DDS modified with target-specific ligands in brain
- Evaluation of efficacy potential of DDS modified with target-specific ligands in glioma-xenografted rodents
- Evaluation of targeting and pharmacokinetic dispositions with target-specific ligands for brain through BBB
○ Screening of anti-tumor potential of anti-tumor chemotherapeutics
○ Establishment of the preparation method of HSA with target-specific ligands for brain through BBB
○ Establishment of the preparation method of albumin nanoparticles
○ Preparation method of PLGA nanoparticles with target-specific ligands for brain through BBB
○ Preparation fo cationized albumin conjugates
○ Establishment of brain glioma-xenografted experimental mice model

Expected Contribution
If this study will succeed, we would expect novel brain-specific nanoparticles formulation for treating brain tumors, which might be commercially valuable and profitable.

(출처 : SUMMARY 6p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 6
• 목차 ... 7
• 1. 연구개발과제의 개요 ... 8
• 2. 국내외 기술개발 현황 ... 9
• 3. 연구수행 내용 및 결과 ... 18
• 2.1. 연구배경 ... 18
• 2.2. 연구범위 ... 18
• 2.3 연구 수행 방법 ... 19
• 2.4. 연구 결과 ... 30
• 4. 목표달성도 및 관련분야 기여도 ... 57
• 4.1 목표달성도 ... 57
• 4.2. 관련 분야 기여도 ... 58
• 5. 연구결과의 활용계획 ... 58
• 6. 연구과정에서 수집한 해외과학기술정보 ... 58
• 7. 연구개발성과의 보안등급 ... 59
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 59
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 60
• 10. 연구개발과제의 대표적 연구실적 ... 61
• 11. 기타사항 ... 61
• 12. 참고문헌 ... 61
• 별첨4. 실적 증빙자료 ... 63
• 별첨5. 기타 첨부서류 ... 71
• 끝페이지 ... 78