초록

Abstract ▼

1. Research Purpose
Diabetes is serious public health concern as it affects around 382 million people worldwide and with over 1 million people living with diabetes in the UAE, the country is placed 15th worldwide for age-adjusted comparative prevalence.[1] International Diabetes Federation (IDF)

1. Research Purpose
Diabetes is serious public health concern as it affects around 382 million people worldwide and with over 1 million people living with diabetes in the UAE, the country is placed 15th worldwide for age-adjusted comparative prevalence.[1] International Diabetes Federation (IDF) revealed that in 2017, 17.3% of the UAE population between the ages of 20 and 79 had type 2 diabetes and the overall number of diabetic patients is expected to double to 2.2 million by 2040. Diabetes as a chronic illness requires constant monitoring of blood glucose concentration to manage insulin administration and dosage.[2, 3] Without systematic glucose monitoring, diabetic ketoacidosis may result in a seizure or coma.[4] Hence, the dosing of insulin must be accurate to tightly control the concentration of glucose. Long-term complications of diabetes are neuropathy, blindness, nerve damage, heart diseases, and kidney failure.[5]

Existing subcutaneous commercial continuous glucose monitoring (CGM) technologies allow for real-time measurements; however, multiple blood extractions per day are required to calibrate the electrochemical sensors, which also degrade over time leading to signal drifts and replacement costs. Therefore, the development of CGM systems to measure glucose concentration for long periods in a reversible manner without frequent calibration and sensor replacement is an unmet need. Our objective is to develop a wearable sensor for prolonged glucose monitoring in vivo (Figure 1). We will create an acrylated bis-boronic acid derivative that can selectively bind with glucose. These glucose-binding molecules will be incorporated into a grating based hydrogel film that will sense the glucose concentrations by means of color changes associated with Bragg peak shifts. The sensor will be subcutaneously operated with color signal propagating out via a hydrogel fiber. To demonstrate the applicability, we will design a wearable readout device that is capable of continuously measuring glucose concentration of the interstitial fluid in subcutaneous tissue.

(출처 : 본문 : 1. Research Purpose 4p)

목차 Contents

• COVER ... 1
• Final Report ... 2
• 1. Research Purpose ... 4
• 2. Research Target Using Progress Chart ... 7
• 3. Research Method ... 8
• 1) Fiber drawing tower and optical fiber fabrication ... 8
• 2) Synthesizing an acrylated bis-boronic acid receptor for continuous glucose recognition ... 10
• 3) Fabrication of diffraction grating based transducer for glucose sensing ... 12
• 4. Research Results ... 15
• (1) Research achievements ... 15
• (2) Further research required ... 18
• Reference ... 21
• End of Page ... 25