Abstract ▼

□ Purpose&Contents
Using transgenic pig for xeno organ transplantation, heart, kidney and cornea transplantations are done. And with the proper immunosupprssion treatment and setting the postoperative intensive care system, ultimately technical background for the xeno organ transplantation to hum

□ Purpose&Contents
Using transgenic pig for xeno organ transplantation, heart, kidney and cornea transplantations are done. And with the proper immunosupprssion treatment and setting the postoperative intensive care system, ultimately technical background for the xeno organ transplantation to human can be established.

□ Results
The progenies of GT^-MCP/-MCP, GT^-MCP/-MCP/CD73 transgenic pig were successfully generated for xenotransplantation research.
With the use of various transgenic pigs, two heart, seven kidney and seven anterior lamellar partial cornea xenotransplantations are done. Especially in cornea and kidney xenotransplantation, long-term survival and improving results are taken. And with the development of immunosuppression therapy method to make long-term survivals and doing analysis of the xenoantigen and inflammation marker in the blood of recipient monkey, data for the immunologic reaction are secured. The PERV analysis of the recipient monkey confirms that transmission of PERV do not occur in pig to monkey.

□ Expected Contribution
Transgenic pigs, increased in available numbers in this study will be provided consistently for xenotransplantation. Acquired surgical techniques of NHP xenotransplantation and various data can establish the way to clinical application and supply the target informations of pig transgenicity. And through the foundation of infrastructure for the research of immune reaction, evaluations, control, basic information and tools for the transplantation rejection mechanisms are provided. And these informations are used to identify the biochemical and physiologic mechanisms of xenotransplantation rejection reactions.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국 문 요 약 문 ... 4
• Summary ... 5
• 목차 ... 6
• 제 1 장 연구 개발 과제의 개요 ... 7
• 제1절 연구 개발 목적 ... 7
• 제2절 연구 개발의 필요성 ... 7
• 제3절 연구 개발 범위 ... 9
• 제 2 장 연구 수행 내용 및 결과 ... 10
• 제1절 형질전환 돼지를 이용한 영장류 이종장기이식의 생존분석(제1세부) ... 10
• 제2절 Gal 항원 없는 유전자형 기반 형질전환 돼지의 이종이식 활용 선발 조건 탐색(제1협동) ... 66
• 제 3 장 목표달성도 및 관련분야 기여도 ... 88
• 제1절 목표대비 달성도 ... 88
• 제2절 정량적 성과(논문게재, 특허출원, 기타)를 기술 ... 88
• 제 4 장 연구 결과의 활용 계획 ... 89
• 제 5 장 연구 개발 결과의 보안 등급 ... 90
• 제 6 장 연구시설·장비종합정보시스템에등록한 연구시설·장비현황 ... 91
• 제 7 장 연구개발과제의 대표적 연구실적 ... 92
• 제 8 장 기타사항 ... 93
• 제 9 장 참고문헌 ... 94
• 끝페이지 ... 95