보고서 정보
주관연구기관 |
고려대학교 Korea University |
연구책임자 |
PATEL KAPIL DEV
|
보고서유형 | 최종보고서 |
발행국가 | 대한민국 |
언어 |
대한민국
|
발행년월 | 2021-06 |
과제시작연도 |
2020 |
주관부처 |
교육부 Ministry of Education |
과제관리전문기관 |
한국연구재단 National Research Foundation of Korea |
등록번호 |
TRKO202100012093 |
과제고유번호 |
1345344367 |
사업명 |
개인기초연구(교육부)(R&D) |
DB 구축일자 |
2022-04-16
|
키워드 |
탄소 나노튜브.전기 방사.나노 섬유.조직 공학.척수 손상.CNTs.Electrospinning.Nanofibers.Tissue Engineering.Spinal cord injury.
|
초록
▼
□ 연구개발 목표 및 내용
■ 최종 목표
척수신경 재생용 카본나노튜브기반 나노섬유-하이드로겔 신경도관 개발
■ 전체 내용
본 연구과제는 전기스핀 기반의 폴리카프로락톤(PCL) 나노섬유의 개발과 기능성 탄소나노튜브(CNT)를 사용해 나노섬유의 표면개질을 개발하였음.
□ 연구개발성과
This research project help me to develop electrospinning based polycaprolactone (PCL) nanofibers and their surface modif
□ 연구개발 목표 및 내용
■ 최종 목표
척수신경 재생용 카본나노튜브기반 나노섬유-하이드로겔 신경도관 개발
■ 전체 내용
본 연구과제는 전기스핀 기반의 폴리카프로락톤(PCL) 나노섬유의 개발과 기능성 탄소나노튜브(CNT)를 사용해 나노섬유의 표면개질을 개발하였음.
□ 연구개발성과
This research project help me to develop electrospinning based polycaprolactone (PCL) nanofibers and their surface modifications with functional carbon nanotubes (CNTs). Fabricated CNTs-functionalized PCL nanofibers were applied for bone, muscle, and nerve tissue regeneration applications. The obtained research and development performances are summarized in three main parts.
(A) Academic aspects
● The developed nanofiberous biomaterials can be used for various tissue regeneration and further development can be continue.
● In this study, the used of CNTs endow multiple platform such as stem cell fate control, drug/biomolecule loading and delivery.
● In addition, electrical conductivity, and mechanical strength of CNTs and nanofibers together provide suitable microenvironments for tissue repair and regeneration.
● Moreover, fabricated bi-modal nanotopographic fiberous scaffolds promotes angiogenesis and minimal inflammation.
(B) The technical aspects
● This research project is targeted for tissue regeneration engineering, particularly nerve tissue engineering for spinal cord regeneration, the impact of developed technology is expected to be immense.
● The drug/biomolecules delivery and controling the cell fate simultaneously is challenging, developed system is reliable for delivering biomolecules for controling tissue responses, expected infinite technical benefits.
(C) Industrial and economic aspects
● The developed research techniques (electrospinning) and functionalization could be potentials for industrial used and can be manufacture at high scale.
● Additionally, developed technique is very simple, versatile, and cost-effective, therefore, can be easily industrialized for production.
● Furthermore, this technology can combined with hydrogels to make three dimensional (3D) nanofiberous-scaffolds and be affordable that can be used domestically or internationally.
□ 연구개발성과 활용계획 및 기대 효과
● Developed nanofibrous scaffold materials is effective for bone, muscle, and nerve regeneration. Therefore, It can be used for multi-tissue regeneration applications.
● The obtained research results leads to achieve innovative strategies and methodologies that can be further in academia and clinical application for spinal cord injury treatment.
(출처 : 요약문 2p)
Abstract
▼
1. 연구개발과제의 개요
* According to the world health organization(WHO), between 250000 and 500000 people suffer spinal cord injury (SCI), every year, around the world [1]. According to Korean Spinal Cord Injury Association (KSCIA), the SC) is afflict a total of 74000 patients in South Korea, and the num
1. 연구개발과제의 개요
* According to the world health organization(WHO), between 250000 and 500000 people suffer spinal cord injury (SCI), every year, around the world [1]. According to Korean Spinal Cord Injury Association (KSCIA), the SC) is afflict a total of 74000 patients in South Korea, and the number is increasing by 2000 each year [2]. In the USA, SCI patient number were approximately 273000 in 2013 and the number is increasing by 12000 new patients each year [3]. In the UK, with an annual incidence of 13 per million, approximately 40000 people live with SCIs [4]. The SCIs patients in developing countries like China, India, Pakistan, Bangladesh, Indonesia, Brazil, and South Africa are significantly higher, which is mainly due to increase of spinal trauma caused by motor vehicle accident, industrial accident, sports, diving, falling down, and violence [5]. Traumatic injuries of SCIs can lead to life-long loss of sensation and voluntary motor function.
* Mechanism of injury associated with SCI frequently results in other life-threatening traumatic injuries. The main complications that injury-associated with vascular damage inevitably include hypoxia, haemorrhage, and edema that accelerate necrosis of damaged neural tissues. Problems associated with SCIs patients are mainly related to physical disability affecting their daily life activities such as and urination and defection. The physical adjustment difficulties are also main reason for suicidal ideation in SCIs patients [5].
* To address these issues, implantable biomaterials have recently attracted huge attention in treatment of SCIs. For effective regeneration, biomaterials must first bridge the gap created by lesion in the spinal tissue by formating an extracellular matrix replacement that supports anchoring of nerve stem cells (NSCs) and promotes axon growth. Biomaterials should also reduce tissue cavitation and glial scarring, allowing effective neo-vascularization. Finally, materials need to play role in modulation of long-term inflammatory response.
* In treating SCI, polycaprolactone (PCL) has been successfully employed in the form of nanofibrous scaffolds or stem cell-seeded nanofibers designed to bridge the tissue gap created by transfection of rat spinal cord [6,7]. However, PCL nanofibers did not support neural differentiation and also very low therapeutic potential. The impact of hydrogel-based biomaterials and its interaction with surrounding tissues and event like scar formation and vascularization are not studied well or very few. Unfortunately, currently established treatments, such as direct drug administration, do not effectively treat SCI due to rapid drug clearance.
* Further, the sustained release of biomolecules such as neurotrophic factors (NT-3) and/or microRNA (miR-222) from collagen hydrogel will synergistically pronounced the axon regeneration process. NT-3 is a neurotrophic factor commonly used SCI treatment to promote neuronal survival and axonal regrowth. The role of NT-3 is for nerve regeneration, and the involvement of microRNAs and RNA interference (RNAi) are only beginning to elucidate. Collagen hydrogel will not only provide the necessary structural supports and directional cues for tissue regrowth and restructuring but also provide localized non-viral delivery system for effective and efficient delivery of NT-3 and miR-222. Collagen will be chosen due to inherent cell adhesivity that support cell attachment compared to other natural polymer biomaterials and also provide natural ECM microenvironment.
* Thus, we proposed CNT-tailored aligned nanofibrous-hydrogel scaffolds system as promising bio-functional platform for SCI treatment. This work will touch the cutting-edge area in SCI therapy through three(material+cell+drug) approach.
(출처 : 본문 5p)
목차 Contents
- COVER ... 1
- 요약문 ... 2
- 목차 ... 4
- 1. 연구개발과제의 개요 ... 5
- 2. 연구개발과제의 수행 과정 및 수행 내용 ... 6
- 3. 연구개발과제의 수행 결과 및 목표 달성 정도 ... 8
- 1) 연구수행 결과 ... 8
- 4. 연구개발성과의 관련 분야에 대한 기여 정도 ... 20
- 5. 연구개발성과의 관리 및 활용 계획 ... 20
- 6. 참고문헌 ... 21
- End of Page ... 21
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