[보고서]2021년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구

문귀임

2021년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2021 원문보기

보고서 정보
주관연구기관	식품의약품안전평가원 National Institute of Food and Drug Safety Evaluation
연구책임자	문귀임
참여연구자	정용현 , 이정미 , 신혜선 , 강성은 , 이수정 , 구선영 , 이소은 , 박채영 , 최장덕 , 최원조 , 박수정 , 김은정 , 김지영 , 박소라 , 전대훈 , 허수정 , 이유선 , 이화미 , 김보람 , 송영빈 , 이영수 , 조영래 , 송지영 , 이정은 , 최근화 , 김효진 , 주현진 , 김종욱 , 정윤미 , 고명진 , 박은희 , 김인경 , 변재언 , 김정연 , 마아영
보고서유형	최종보고서
발행국가	대한민국
언어	한국어
발행년월	2021-12
과제시작연도	2021
주관부처	식품의약품안전처 Ministry of Food and Drug Safety
등록번호	TRKO202300003839
과제고유번호	1475012600
사업명	농축수산안전관리(R&D)
DB 구축일자	2023-07-26
키워드	잔류농약.위해평가.시험법.시험법 검증.Pesticide residue.Risk assessment.Analytical method.Validation.

초록 ▼

잔류농약으로부터 안전한 식품을 국민들에게 공급하기 위해 신규농약에 대한 시험법을 개발하고, 기준 제·개정 농약에 대한 위해평가를 수행하였다. 2021년 신규 기준 설정 농약 8종(플로릴피콕사미드, 플루인다피르, 에티프롤, 멥틸디노캅, 플루아자인돌리진, 니트라피린, 스피로피디온, 아이소사이클로세람)에 대한 8개 시험법을 개발하고 지방청(서울청, 광주청)과 연계하여 시험법의 특이성, 직선성, 정량한계, 정확성, 정밀성 등 실험실간 시험법 검증을 완료하였다. 이 중 니트라피린, 플로릴피콕사미드 및 아이소사이클로세람은 잔류물의 정의에 대사산물이 포함됨에 따라 모화합물과 대사산물을 동시에 분석할 수 있는 동시시험법으로 개발하였으며, 멥틸디노캅은 잔류물의 정의에 따라 멥틸디노캅의 대사산물인 2,4-DNOP로 전환하여 분석하는 시험법으로 개발하였다.

또한, 이미녹타딘 등 신규 및 기준 확대 농약 207종에 대한 위해평가를 실시하였으며, 위험성 확인 및 결정을 위해 국내·외 독성자료를 확보하고 안전성에 대한 검토를 거쳐 ADI, NOAEL, 안전계수를 제시하였다. 식품섭취량, 국민평균 체중 등을 반영하여 노출평가를 수행하였고, 인체안전기준치인 ADI 대비 TMDI 또는 EDI 값을 산출하여 위해평가를 수행하였다. 207종 중 200종 농약은 ADI 대비 TMDI 또는 EDI가 80% 미만으로 안전한 수준으로 평가되었으며, 비터타놀 등 7종은 80%가 넘었으나 잠정 잔류허용기준 불포함 시에는 80% 미만으로 나타났다. 또한, 신규 농약인 에티프롤, 니트라피린은 원제의 일반독성, 생식 및 발생독성, 유전독성, 발암성, 대사 및 기타 독성 등 각 독성 분야의 전문가들과 안전성을 검토하여 ADI를 결정하였다.

(출처 : 요약문 4p)

Abstract ▼

This study was conducted to ensure the safety of pesticide residue in food. To provide scientific evidence to support this claim. performing risk assessments to establish MRL and developing analytical method to confirm suitability of MRL were conducted. In addition, reagent share system was carried out to cut down national budget and to buildup rapid and efficient pesticide residue test among national inspection institutes. First of all, analytical methods for newly registered 8 pesticides(nitrapyrin, meptyldinocap, spiropidion, isocycloseram, ethiprole, florylpicoxamid, fluazaindolizine, fluindapyr) were developed. The developed methods of 8 pesticides were validated by the parameter such as linearity, specificity, limit of quantification, precision, and recovery in representative crops and completed inter-laboratory validation with regional MFDS(Seoul, Gwangiu).

Risk assessment was conducted to evaluate MRL proposals of 207 pesticides including iminoctadine by reviewing the domestic and foreign toxic materials, providing ADI, NOAEL, ARfD, safety factor, performing exposure assessment based on national weight, judging the safety by calculating ADI contrast TMDI or EDI percentage, and finally creating toxic profiles and updating. In results of risk assessment, 200 kinds of pesticides have been assessed as safe, but 7 kinds of pesticides including bitertanol have been exceeded 80%, when the provisional residual limit was included. In addition, new pesticides such as ethiprole and nitrapyrin were reviewed for safety with experts in each toxic field, including general toxicity, reproductive and developmental toxicity, genetic toxicity, carcinogenicity, metabolism, and other toxicity of the active ingredient to determine ADI.

(source : Summary 5p)

목차 Contents

표지 ... 1
최종보고서 ... 2
국문 요약문 ... 4
Summary ... 5
목차 ... 6
연구개발과제 연구결과 ... 7
제1장 연구개발과제의 개요 ... 7
제1절 연구개발과제의 목표 ... 7
제2절 연구개발과제의 필요성 ... 8
제2장 연구개발과제의 국내·외 연구개발 현황 ... 12
제1절 국내 연구개발 현황 ... 12
제2절 국외 연구개발 현황 ... 19
제3장 연구개발과제의 연구수행 내용 및 결과 ... 25
제1절 잔류농약 시험법 확립 및 검증 ... 25
제2절 잔류농약 위해평가 ... 634
제4장 연구개발과제의 연구결과 고찰 및 결론 ... 733
제1절 잔류농약 시험법 확립 ... 733
제2절 잔류농약 위해평가 ... 733
제5장 연구개발과제의 목표달성도 및 관련분야에의 기여도 ... 736
제1절 목표달성도 ... 736
제2절 관련분야에의 기여도 ... 736
제6장 연구개발과제의 연구개발 결과 활용계획 ... 737
제1절 연구성과 및 활용계획 ... 737
제7장 참고문헌 ... 740
제8장 첨부서류 ... 742
끝페이지 ... 776

표/그림 (300)

표 Validation parameters
표 Guidelines on method development of pesticide residue : fortification concentration and replication
표 Guidelines on method development of pesticide residue recovery and relative standard deviation (Codex guideline)
표 Guidelines on method development of pesticide residue : Limit of quantitation (Codex guideline)
표 Representative agricultural products for development of pesticide residue analytical method
표 Procedures for development of an analytical method for the determination of pesticide residue in agricultural products
표 일본의 위해관리와 위해평가 조직 구성도
표 Molecular structures of florylpicoxamid and metabolite(X12485649)
표 Physicochemical characteristics of florylpicoxamid and metabolite (X12485649)
표 Scheme for preparing matrix-matched calibration standards
표 The recovery results of florylpicoxamid and metabolite(X12485649) according to three QuEChERS method in mandarin and soybean samples
표 The recovery results of d-SPE for the determination of florylpicoxamid and metabolite(X12485649)
표 Procedure of extraction for florylpicoxamid and metabolites(X12485649) analysis
표 Procedure of purification for florylpicoxamid and metabolites(X12485649) analysis
표 Flow chart for florylpicoxamid and metabolites(X12485649) analysis
표 Analytical conditions for the determination of florylpicoxamid and metabolites(X12485649)
표 Selected-ion of LC-MS/MS for florylpicoxamid and metabolite(X12485649)
표 LC-MS/MS chromatograms of florylpicoxamid standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of florylpicoxamid(concentration : 0.001 –0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of X12485649(concentration : 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of florylpicoxamid and metabolite(X12485649) residues in samples
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Analytical conditions for the determination of florylpicoxamid and metabolite(X12485649)
표 Selected-ion of LC-MS/MS for florylpicoxamid and metabolite(X12485649)
표 LC-MS/MS chromatograms of florylpicoxamid standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of florylpicoxamid standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of X12485649 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of florylpicoxamid (concentration : 0.001–0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of X12485649 (concentration : 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of florylpicoxamid and its metabolites residues in samples
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of florylpicoxamid in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of X12485649 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Validation results of florylpicoxamid and its metabolite
표 Inter-laboratory validation results of analytical method for florylpicoxamid in samples
표 Inter-laboratory validation results of analytical method for X12485649 in samples
표 Molecular structures of fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990)
표 Physicochemical characteristics of fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990)
표 Scheme for preparing matrix-matched calibration standards
표 The recovery results of fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) according to three QuEChERS method in mandarin and soybean samples
표 The recovery results of fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) in samples
표 Procedure of extraction for fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) analysis
표 Procedure of purification for fluindapyr and its metabolites(1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) analysis
표 Flow chart for fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) analysis
표 Analytical conditions for the determination of fluindapyr and its metabolites(1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990)
표 Selected-ion of LC-MS/MS for fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990)
표 LC-MS/MS chromatograms of fluindapyr standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of fluindapyr(concentration : 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of 1-hydroxymethyl-F9990 (concentration : 0.001–0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of 3-hydroxy-IR9792/F9990 (concentration : 0.001–0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of fluindapyr and metabolites(1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990) residues in samples
표 Representative MRM(quantification ion) chromatograms of fluindapyr in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/F9990 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/F9990 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/F9990 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/F9990 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/F9990 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Analytical conditions for the determination of fluindapyr
표 Selected-ion of LC-MS/MS for fluindapyr
표 LC-MS/MS chromatograms of fluindapyr standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of fluindapyr standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 1-hydroxymethyl-F9990 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 3-hydroxy-IR9792/F9990 standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of fluindapyr(concentration : 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of 1-hydroxymethyl-F9990 (concentration : 0.001–0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of 3-hydroxy-IR9792/F9990 (concentration : 0.001–0.05 ppm) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of fluindapyr and its metabolites residues in samples
표 Representative MRM(quantification ion) chromatograms of fluindapyr in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of fluindapyr in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 1-hydroxymethyl-F9990 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/ F9990 in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/ F9990 in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/ F9990 in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792/ F9990 in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 3-hydroxy-IR9792 /F9990 in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Validation results of fluindapyr and its metabolites (1-hydroxymethyl-F9990, 3-hydroxy-IR9792/F9990)
표 Inter-laboratory validation results of analytical method for fluindapyr in samples
표 Inter-laboratory validation results of analytical method for 1-hydroxymethyl-F9990 in samples
표 Inter-laboratory validation results of analytical method for 3-hydroxy-IR9792/F9990 in samples
표 Molecular structure of ethiprole
표 Physicochemical characteristics of ethiprole
표 Scheme for preparing matrix-matched calibration standards
표 The extraction efficiency of ethiprole according to three QuEChERS method in mandarin
표 The extraction efficiency of ethiprole according to three QuEChERS method and the amount of water in soybean
표 The purification efficiency of ethiprole according to d-SPE sorbent in soybean
표 Procedure of extraction for ethiprole analysis
표 Procedure of purification for ethiprole analysis
표 Flow chart for ethiprole analysis
표 LC-MS/MS chromatograms of ethiprole standards in mandarin matrix according to the initial content of acetonitrile (A) 30%, (B) 20%, (C) 10% and (D) 5%
표 Analytical conditions for the determination of ethiprole
표 Selected-ion of LC-MS/MS for ethiprole
표 LC-MS/MS chromatograms of ethiprole standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of ethiprole(concentration : 0.001-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of ethiprole
표 Representative MRM(quantification ion) chromatograms of ethiprole in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Analytical conditions for the determination of ethiprole
표 Selected-ion for the determination of ethiprole
표 LC-MS/MS chromatograms of ethiprole standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of ethiprole standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of ethiprole(concentration : 0.001-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of ethiprole residues in samples
표 Representative MRM(quantification ion) chromatograms of ethiprole in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of ethiprole in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Validation results of ethiprole
표 Inter-laboratory validation results of analytical method for ethiprole in samples
표 Molecular structures of meptyldinocap and metabolite(2,4-DNOP)
표 Physicochemical characteristics of meptyldinocap and metabolite(2,4-DNOP)
표 Scheme for preparing matrix-matched calibration standards
표 Comparisons of acetonitrile for 2,4-DNOP extract efficiency in hulled rice and mandarin sample
표 Comparisons of extract effciency according amount of added NaOH in standard solution
표 Comparisons of d-SPE sorbent for purification efficiency of 2,4-DNOP in standard solution
표 Comparisons of recovery results for 2,4-DNOP in five sample
표 Procedure of extraction for meptyldinocap and metabolites(2,4-DNOP) analysis
표 Procedure of purification for meptyldinocap and metabolites(2,4-DNOP) analysis
표 Flow chart for 2,4-DNOP analysis
표 Analytical conditions for the determination of 2,4-DNOP
표 Selected-ion of LC-MS/MS for 2,4-DNOP
표 LC-MS/MS chromatograms of 2,4-DNOP standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of 2,4-DNOP(concentration: 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of 2,4-DNOP residues in samples
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Analytical conditions for the determination of 2,4-DNOP
표 Selected-ion of LC-MS/MS for 2,4-DNOP
표 LC-MS/MS chromatograms of 2,4-DNOP standards in hulled rice matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in potato matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in soybean matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in mandarin matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of 2,4-DNOP standards in green pepper matrix (A) 0.001 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 Matrix-matched calibration curves of 2,4-DNOP (concentration : 0.001– 0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of 2,4-DNOP residues in samples
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion) chromatograms of 2,4-DNOP in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Validation results of 2,4-DNOP
표 Inter-laboratory validation results of analytical method for 2,4-DNOP in samples
표 Molecular structure of fluazaindolizine and its metabolites
표 Physicochemical characteristics of fluazaindolizine and its metabolites
표 Scheme for preparing matrix-matched calibration standards for fluazaindolizine
표 Scheme for preparing matrix-matched calibration standards for 7 metabolites
표 The extraction efficiency of 7 metabolites according to the ratio of methanol and water mixture and the number of extraction in mandarin
표 The extraction efficiency of 7 metabolites according to three QuEChERS method in mandarin
표 The extraction efficiency of 7 metabolites according to pH of extraction solvent using Original QuEChERS method in mandarin
표 The extraction efficiency of 7 metabolites according to the ratio of acetonitrile and water mixture in soybean
표 The recovery results of 7 metabolites from HLB cartridge
표 The recovery results of 7 metabolites from MAX cartridge
표 The recovery results of 7 metabolites from MCX cartridge
표 The recovery results of 7 metabolites from HLB cartridge according to methanol ratio in water
표 The recovery results of 7 metabolites from C18 cartridge according to
표 Procedure of extraction for fluazaindolizine analysis
표 Procedure of purification for fluazaindolizine analysis
표 Procedure of extraction for 7 metabolites analysis
표 Procedure of purification for 7 metabolites analysis
표 Flow chart for fluazaindolizine analysis
표 Flow chart for 7 metabolites analysis
표 Analytical conditions for the determination of fluazaindolizine and 7 metabolites
표 Selected-ion of LC-MS/MS for fluazaindolizine and 7 metabolites
표 LC-MS/MS chromatograms of fluazaindolizine (left) and IN-QEK31 (right) standards in hulled rice matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) standards in hulled rice matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-A5760 (left) and IN-F4106 (right) standards in hulled rice matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of IN-QZY47 (left) and IN-UJV12 (right) standards in hulled rice matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of fluazaindolizine (left) and IN-QEK31 (right) standards in potato matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) standards in potato matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-A5760 (left) and IN-F4106 (right) standards in potato matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of IN-QZY47 (left) and IN-UJV12 (right) standards in potato matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of fluazaindolizine (left) and IN-QEK31 (right) standards in soybean matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) standards in soybean matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-A5760 (left) and IN-F4106 (right) standards in soybean matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of IN-QZY47 (left) and IN-UJV12 (right) standards in soybean matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of fluazaindolizine (left) and IN-QEK31 (right) standards in mandarin matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) standards in mandarin matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-A5760 (left) and IN-F4106 (right) standards in mandarin matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of IN-QZY47 (left) and IN-UJV12 (right) standards in mandarin matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of fluazaindolizine (left) and IN-QEK31 (right) standards in green pepper matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) standards in green pepper matrix (A) 0.002 mg/L, (B) 0.0025 mg/L, (C) 0.005 mg/L, (D) 0.01 mg/L, (E) 0.025 mg/L and (F) 0.05 mg/L
표 LC-MS/MS chromatograms of IN-A5760 (left) and IN-F4106 (right) standards in green pepper matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 LC-MS/MS chromatograms of IN-QZY47 (left) and IN-UJV12 (right) standards in green pepper matrix (A) 0.01 mg/L, (B) 0.0125 mg/L, (C) 0.025 mg/L, (D) 0.05 mg/L, (E) 0.125 mg/L and (F) 0.25 mg/L
표 Matrix-matched calibration curves of fluazaindolizine (concentration : 0.002-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-QEK31 (concentration : 0.002-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-TMQ01 (concentration : 0.002-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-UNS90 (concentration : 0.002-0.05 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-A5760 (concentration : 0.01-0.25 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-F4106 (concentration : 0.01-0.25 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-QZY47 (concentration : 0.01-0.25 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of IN-UJV12 (concentration : 0.01-0.25 mg/L) in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of fluazaindolizine and 7 metabolites residues in samples
표 Representative MRM(quantification ion chromatograms of fluazaindolizine (left) and IN-QEK31 (right) in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-A5760 (left) and IN-F4106 (right) in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-QZY47 (left) and IN-UJV12 (right) in hulled rice corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of fluazaindolizine (left) and IN-QEK31 (right) in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-A5760 (left) and IN-F4106 (right) in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-QZY47 (left) and IN-UJV12 (right) in potato corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of fluazaindolizine (left) and IN-QEK31 (right) in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-A5760 (left) and IN-F4106 (right) in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-QZY47 (left) and IN-UJV12 (right) in soybean corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of fluazaindolizine (left) and IN-QEK31 (right) in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-A5760 (left) and IN-F4106 (right) in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-QZY47 (left) and IN-UJV12 (right) in mandarin corresponding to : (A) control sample, (B) matrix matched standard at 0.125 mg/L, (C) sample spiked at 0.05 mg/kg and (D) sample spiked at 0.5 mg/kg
표 Representative MRM(quantification ion chromatograms of fluazaindolizine (left) and IN-QEK31 (right) in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg
표 Representative MRM(quantification ion chromatograms of IN-TMQ01 (left) and IN-UNS90 (right) in green pepper corresponding to : (A) control sample, (B) matrix matched standard at 0.025 mg/L, (C) sample spiked at 0.01 mg/kg and (D) sample spiked at 0.1 mg/kg

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2021년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2021 원문보기

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2021년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
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