[보고서]2018년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구

이강봉

2018년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2018 원문보기

보고서 정보
주관연구기관	식품의약품안전평가원 National Institute of Food and Drug Safety Evaluation
연구책임자	이강봉
참여연구자	정용현 , 도정아 , 조병훈 , 이상목 , 최원조 , 이정미 , 강희승 , 신혜선 , 장동은 , 박신민 , 조성민 , 이한솔 , 박지수 , 김도훈 , 김종수 , 김지영 , 송지영 , 김효진 , 홍순근 , 이영주 , 박인주 , 우현경 , 한아름 , 성누리 , 문귀임 , 정윤미 , 조명식 , 고명진 , 김인경 , 김정연 , 박은희 , 박지원 , 변재언 , 장운기 , 최유희 , 최하나
보고서유형	최종보고서
발행국가	대한민국
언어	한국어
발행년월	2018-12
과제시작연도	2018
주관부처	식품의약품안전처 Ministry of Food and Drug Safety
등록번호	TRKO201900003464
과제고유번호	1475010491
사업명	식품등안전관리(R&D)
DB 구축일자	2019-07-13
키워드	잔류농약.위해평가.시험법.표준품.시험법 검증.Pesticide residue.Risk assessment.Analytical method.Pesticide standard.Validation.
DOI	https://doi.org/10.23000/TRKO201900003464

초록 ▼

잔류농약으로부터 안전한 식품을 국민들에게 공급하기 위해 신규농약에 대한 시험법을 개발하고, 기준 제·개정 농약에 대한 위해평가를 수행하였다. 또한, 우리나라 잔류농약 국가검사기관에 농약 표준품을 제공하여 신속 검사를 지원하고 일관된 결과를 도출하도록 하였다. 2018년 신규 기준 설정 농약 15종(발리다마이신A, 브로플라닐라이드, 비사이클로피론, 세닥산, 스트렙토마이신, 아세토클로르, 옥시테트라사이클린, 이미다클로프리드, 이프로디온, 퀴녹시펜, 클로피랄리드, 펜프로피모르프, 플루치아셋-메틸, 피디플루메토펜, 피라지플루미드)에 대한 시험법을 개발하고 지방청(서울청, 광주청) 및 산업체(한국식품과학연구원)과 연계하여 시험법의 특이성, 직선성, 정량한계, 정확성, 정밀성 등을 토대로 실험실간 시험법 검증을 완료하였다. 이 중 브로플라닐라이드, 비사이클로피론, 스트렙토마이신, 아세토클로르, 이미다클로프리드, 플루치아셋-메틸은 잔류물의 대상에 대사산물이 포함되었기에 대사산물을 동시에 분석할 수 있도록 개발하였다. 또한, 이미녹타딘 등 신규 및 기준 확대 농약 333종에 대한 위해평가를 실시하였으며, 위험성 확인 및 결정을 위해 국내외 독성자료를 확보하고 안전성에 대한 검토를 거쳐 ADI, NOAEL, 안전계수를 제시하였다. 식품섭취량, 국민평균 체중 등을 반영하여 노출평가를 수행하였고, 인체안전기준치인 ADI 대비 TMDI 값을 산출하여 위해평가를 수행하였다.
333종 중 잠정 잔류허용기준 포함 시 80% 이상인 농약은 19종이었으나 잠정 잔류허용기준 불포함 시에는 TMDI 값이 모두 80% 이하였다. 또한, 신규농약인 아미노피랄리드 등 4종은 원제의 일반독성, 생식 및 발달독성, 유전독성, 발암성, 대사 및 기타 독성 등 각 독성 분야의 전문가들과 안전성을 검토하여 ADI를 결정하였다. 마지막으로 지방식약청과 시․도 보건환경연구원 및 국립농산물품질관리원 시험연구소 등 국가 잔류농약 검사기관을 대상으로 신속한 분석업무를 지원하기 위해 잔류농약 표준시약을 지원하였다. 이를 위해 ‘잔류농약데이터베이스’ 홈페이지를 활용하여 표준시약 현황을 수시로 업그레이드 하여 실시간 공유하였고, 온라인 접수를 통하여 신속하게 필요한 표준시약을 공유하였다. 29개 기관에서 표준품 지원 신청품목은 다이아지논 등 387종이었으며, 1,326건 지원을 완료하였다. 이는 각 기관에 신속히 농약 표준품을 지원하고 기관 간 분석오차를 줄여 우리나라 시험검사 시스템의 신뢰도를 높일 수 있었던 것으로 판단된다.

(출처 : 요약문 2p)

Abstract ▼

This study was conducted to ensure the safety of pesticide residue in food. To provide scientific evidence to support this claim, performing risk assessments to establish MRL and developing analytical method to confirm suitability of MRL were conducted. In addition, reagent share system was carried out to cut down national budget and to buildup rapid and efficient pesticide residue test among national inspection institutes. First of all, analytical methods for newly registered 15 pesticides(validamycin, brofalnilide, bicyclopyrone, sedaxane, streptomycin, acetochlor, oxytetracycline, imidacloprid, iprodione, quinoxyfen, clopyralid, fenpropimorph, fluthiacet-methyl, pydiflumetofen, pyraziflumid) were developed. The developed methods of 15 newly registered pesticides were validated by the parameter such as linearity, specificity, limit of quantification, precision, and recovery in representative crops and completed inter-laboratory validation with regional MFDS (Seoul, Gwangiu) and KAFRI(Korea Advanced Food Research Instiitude). Risk assessment was conducted to evaluate MRL proposals of 333 pesticides including iminoctadine by reviewing the domestic and foreign toxic materials, providing ADI, NOAEL, aRfD, safety factor, performing exposure assessment based on national weight, judging the safety by calculating ADI contrast TMDI percentage, and finally creating toxic profiles and updating. In results of risk assessment, 333 kinds of pesticides have been assessed as safe. Pesticides standards were shared 1,326 species including diazinon in the 29 national pesticide residue inspection institutes. This suggests that it was possible to improve the reliability of the test and inspection system in Korea by supporting the pesticides standard product quickly and reducing the analysis error between the institution.

(출처 : Summary 3p)

목차 Contents

표지 ... 1
국문 요약문 ... 2
Summary ... 3
목차 ... 4
연구개발과제 연구결과 ... 5
제1장 연구개발과제의 개요 ... 5
제1절 연구개발과제의 목표 ... 5
제2절 연구개발과제의 필요성 ... 6
제2장 연구개발과제의 국내·외 연구개발 현황 ... 13
제1절 국내 연구개발 현황 ... 13
제2절 국외 연구개발 현황 ... 23
제3장 연구개발과제의 연구수행 내용 및 결과 ... 30
제1절 잔류농약 시험법 확립 및 검증 ... 30
제2절 잔류농약 위해평가 ... 875
제3절 국가 잔류농약 표준품 지원 ... 1055
제4장 연구개발과제의 연구결과 고찰 및 결론 ... 1064
제1절 잔류농약 시험법 확립 ... 1064
제2절 잔류농약 위해평가 ... 1068
제3절 국가 잔류농약 표준품 지원 ... 1068
제5장 연구개발과제의 목표달성도 및 관련분야에의 기여도 ... 1069
제1절 목표달성도 ... 1069
제2절 관련 분야에의 기여도 ... 1070
제6장 연구개발과제의 연구개발 결과 활용계획 ... 1071
제7장 참고문헌 ... 1074
제8장 첨부서류 ... 1076
끝페이지 ... 1133

표/그림 (300)

표 위해평가 개요
표 농약 잔류허용기준 설정 흐름도
표 Status of establishment of MRLs in livestocks
표 Validation parameters
표 Guidelines on method development of pesticide residue : fortification concentration and replication
표 Guidelines on method development of pesticide residue recovery and relative standard deviation (Codex guideline)
표 Guidelines on method development of pesticide residue : Limit of quantitation (Codex guideline)
표 Representative agricultural products for development of pesticide residue analytical method
표 Procedures for development of an analytical method for the determination of pesticide residue in agricultural products
표 국내법상 위해평가 대상 및 범위
표 식품의약품안전처 위해평가 관여 부서
표 Status of the pesticide standards sharing
표 일본의 위험 관리와 위험 평가 조직 구성도
표 Molecular structure of validamycin A
표 Physicochemical characteristics of validamycin A
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of validamycin A
표 Procedure of purification for validamycin A
표 Flow chart for validamycin A
표 Analytical conditions for the determination of validamycin A
표 Selected-ion of LC-MS/MS for validamycin A
표 LC-MS/MS chromatograms of validamycin A standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.05 mg/kg and (F) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in potato matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.05 mg/kg and (F) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in soybean matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.05 mg/kg and (F) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.05 mg/kg and (F) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.05 mg/kg and (F) 0.1 mg/kg
표 Validation results of analytical method for the determination of validamycin-A residues in samples
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the LC-MS/MS
표 Selected-ion for the determination of validamycin A
표 LC-MS/MS chromatograms of validamycin A standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in potato matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in soybean matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.1 mg/kg
표 LC-MS/MS chromatograms of validamycin A standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.1 mg/kg.
표 LC-MS/MS chromatograms of validamycin A standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.02 mg/kg, (E) 0.1 mg/kg
표 Matrix-matched calibration curves of corresponding to validamycin A in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of validamycin-A residues in samples
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of validamycin A corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Validation results of validamycin A
표 Inter-laboratory validation results of analytical method for validamycin A in samples
표 Proposed metabolic pathway of broflanilide in soybean, tomato and cabbage
표 Physicochemical characteristics of broflanilide ana metabolites(DM-8007 and S(PFP-OH)-8007)
표 Scheme for preparing matrix-matched calibration standards
표 Recovery results of QuEChERS extraction method for the determination of broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007)
표 Recovery results of d-SPE for the determination of broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007)
표 Recovery results of wetting for the determination of broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007)
표 Flow chart for broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007)
표 Analytical conditions for the determination of broflanilide, DM-8007 and S(PFP-OH)-8007
표 Selected-ion of LC-MS/MS for broflanilide, DM-8007 and S(PFP-OH)-8007
표 LC-MS/MS chromatograms of broflanilide standards in hulled rice; (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in potato; (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 Matrix-matched calibration curves of corresponding to broflanilide in ((B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of corresponding to DM-8007 in (A) hulled (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of corresponding to S(PFP-OH)-8007 in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007) residues in samples
표 Representative MRM(quantification ion) chromatograms of broflanilide in hulled rice corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide in potato corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide in soybean corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide in mandarin corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide in green pepper corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 in hulled rice corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 in potato corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 in soybean corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 in mandarin corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 in green pepper corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 in hulled rice corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 in potato corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 in soybean corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 in mandarin corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 in green pepper corresponding to: (A) standard solution at 0.04 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of Broflanilide and its metabolites
표 Selected-ion for the determination of Broflanilide and its metabolites
표 LC-MS/MS chromatograms of broflanilide standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in potato matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of broflanilide standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of DM-8007 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 LC-MS/MS chromatograms of S(PFP-OH)-8007 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg (E) 0.1 mg/kg and (F) 0.2 mg/kg
표 Matrix-matched calibration curves of corresponding to broflanilide and its metabolites (DM-8007 and S(PFP-OH)-8007) in (A) Hulled rice, (B) Potato, (C) Soybean, (D) Mandarin and (E) green Pepper
표 Validation results of analytical method for the determination of broflanilide and its metabolites(DM-8007 and S(PFP-OH)-8007) residues in samples
표 Representative MRM(quantification ion) chromatograms of broflanilide corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.2 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide corresponding to: (A) standard solution at 0.05 mg/kg, (B) bean control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide corresponding to: (A) standard solution at 0.1 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of broflanilide corresponding to: (A) standard solution at 0.05 mg/kg, (B) green pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) bean control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of DM-8007 corresponding to: (A) standard solution at 0.1 mg/kg, (B) pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) bean control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of S(PFP-OH)-8007 corresponding to: (A) standard solution at 0.1 mg/kg, (B) pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Validation results of Broflanilide, DM-8007, S(PFP-OH)-8007
표 Inter-laboratory validation results of analytical method for broflanilide in samples
표 Inter-laboratory validation results of analytical method for DM-8007 in samples
표 Inter-laboratory validation results of analytical method for S(PFP-OH)-8007 in samples
표 Proposed metabolic pathway of bicyclopyrone in plant
표 Molecular structure of bicyclopyrone and metabolites(SYN503780 and CSCD686480)
표 Scheme for preparing matrix-matched calibration standards
표 Comparisons of oxidation conditions for the determination of bicyclopyrone, SYN503780 and CSCD686480
표 Comparisons of liquid-liquid partition conditions for the determination of bicyclopyrone, SYN503780 and CSCD686480
표 Comparisons of elution solvents and cartridges for bicyclopyrone and its metabolites analysis
표 Comparisons of elution solvents and cartridges for bicyclopyrone and its metabolites analysis
표 Procedure of extraction for bicyclopyrone and its metabolites(SYN503780 and CSCD686480) analysis
표 Procedure of purification for bicyclopyrone and its metabolites(SYN503780 and CSCD686480) analysis
표 Flow chart for bicyclopyrone and metabolites(SYN503780 and CSCD686480)
표 Analytical conditions for the determination of bicyclopyrone, SYN503780 and CSCD686480
표 Selected-ion of LC-MS/MS for bicyclopyrone, SYN503780 and CSCD686480
표 LC-MS/MS chromatograms of SYN503780 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standard in green pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standard in green pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, and (F) 0.25 mg/kg
표 Matrix-matched calibration curves of corresponding to: (1) SYN503780 and (2) CSCD686480 in (A) hulled rice, (B) potato (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of bicyclopyrone residues in samples
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) green pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) green pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Analytical conditions for the determination of SYN503780 and CSCD686480
표 Selected-ion of LC-MS/MS for SYN503780 and CSCD686480
표 LC-MS/MS chromatograms of SYN503780 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of SYN503780 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standards in hulled rice matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standards in potato matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standards in soybean matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standards in mandarin matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of CSCD686480 standards in green pepper matrix (A) 0.0025 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg (F) 0.25 mg/kg
표 Matrix-matched calibration curves of corresponding to: (1) SYN503780 and (2) CSCD686480 in (A) hulled rice, (B) potato (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of bicyclopyrone residues in samples
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of SYN503780 corresponding to: (A) standard solution at 0.05 mg/kg, (B) green pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of CSCD686480 corresponding to: (A) standard solution at 0.05 mg/kg, (B) green pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Validation results of bicyclopyrone
표 Inter-laboratory validation results of analytical method for bicyclopyrone in samples
표 Molecular structure of sedaxane
표 Physicochemical characteristics of sedaxane
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of sedaxane
표 Procedure of extraction for sedaxane analysis
표 Procedure of partition for sedaxane analysis
표 Procedure of purification for sedaxane analysis
표 Flow chart for sedaxane
표 Analytical conditions for the determination of sedaxane
표 Selected-ion of LC-MS/MS for sedaxane
표 LC-MS/MS chromatograms of sedaxane standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standards in potato matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standards in soybean matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 Matrix-matched calibration curves of corresponding to: sedaxane in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of sedaxane residues in samples
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) hulled rice control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) potato control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) soybean control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) mandarin control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) green pepper control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Analytical conditions for the determination of Sedaxane
표 Selected-ion of LC-MS/MS for Sedaxane
표 LC-MS/MS chromatograms of sedaxane standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of sedaxane standard in green pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.025 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg and (F) 0.25 mg/kg
표 Matrix-matched calibration curves of corresponding to: sedaxane in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of sedaxane residues in samples
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) hulled rice control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) potato control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) soybean control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) mandarin control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of sedaxane corresponding to: (A) green pepper control, (B) standard solution at 0.05 mg/kg, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Validation results of sedaxane
표 Inter-laboratory validation results of analytical method for sedaxane in samples
표 Molecular structures of streptomycin and dihydrostreptomycin
표 Physicochemical characteristics of streptomycin and dihydrostreptomycin
표 Scheme for preparing matrix-matched calibration standards
표 Procedure of extraction for streptomycin analysis
표 Flow chart for streptomycin analysis
표 Analytical conditions for the determination of streptomycin
표 Selected-ion of LC-MS/MS for streptomycin and dihydrostreptomycin
표 LC-MS/MS chromatograms of streptomycin standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 Matrix-matched calibration curves of corresponding to streptomycin in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of corresponding to dihydrostreptomycin in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of streptomycin residues in samples
표 Validation results of analytical method for the determination of dihydrostreptomycin residues in samples
표 Representative MRM(quantification ion) chromatograms of streptomycin corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of streptomycin
표 Selected-ion of LC-MS/MS for streptomycin and dihydrostreptomycin
표 LC-MS/MS chromatograms of streptomycin standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of streptomycin standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of dihydrostreptomycin standards in green pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 Matrix-matched calibration curves of corresponding to streptomycin in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Matrix-matched calibration curves of corresponding to dihydrostreptomycin in (A) hulled rice, (B) potato, (C) soybean, (D) mandarin and (E) green pepper
표 Validation results of analytical method for the determination of streptomycin residues in samples
표 Validation results of analytical method for the determination of dihydrostreptomycin residues in samples
표 Representative MRM(quantification ion) chromatograms of streptomycin in hulled rice corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin in potato corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin in soybean corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin in mandarin corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of streptomycin in green pepper corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin in hulled rice corresponding to: (A) hulled rice control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin in potato corresponding to: (A) potato control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin in soybean corresponding to: (A) soybean control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin in mandarin corresponding to: (A) mandarin control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of dihydrostreptomycin in green pepper corresponding to: (A) green pepper control, (B) standard solution at 0.1 mg/kg, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Validation results of streptomycin and dihydrostreptomycin
표 Inter-laboratory validation results of analytical method for streptomycin in samples
표 Inter-laboratory validation results of analytical method for dihydrostreptomycin in samples
표 Proposed metabolic pathways of acetochlor in plant
표 Molecular structures of acetochlor and its metabolites
표 Physicochemical characteristics of acetochlor and its metablites
표 Scheme for preparing matrix-matched calibration standards
표 pKa graphs of EMA and HEMA
표 Procedure of extraction for acetochlor and its metabolites analysis
표 Procedure of purification for acetochlor and its metabolites
표 Flow chart for acetochlor and its metabolites
표 Analytical conditions for the determination of acetochlor and its metabolites
표 Selected-ion of LC-MS/MS for acetochlor and its metabolites
표 LC-MS/MS chromatograms of acetochlor standards in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.05 mg/kg, (D) 0.1 mg/kg, (E) 0.25 mg/kg and (F) 0.5 mg/kg
표 LC-MS/MS chromatograms of acetochlor standards in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.05 mg/kg, (D) 0.1 mg/kg, (E) 0.25 mg/kg and (F) 0.5 mg/kg
표 LC-MS/MS chromatograms of acetochlor standards in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.05 mg/kg, (D) 0.1 mg/kg, (E) 0.25 mg/kg and (F) 0.5 mg/kg

과제명(ProjectTitle) :	-
연구책임자(Manager) :	-
과제기간(DetailSeriesProject) :	-
총연구비 (DetailSeriesProject) :	-
키워드(keyword) :	-
과제수행기간(LeadAgency) :	-
연구목표(Goal) :	-
연구내용(Abstract) :	-
기대효과(Effect) :	-

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 제목(한글), 저자명(한글), 발행일자, 전자원문, 초록(한글), 초록(영문) 관리번호, 제목(한글), 제목(영문), 저자명(한글), 저자명(영문), 주관연구기관(한글), 주관연구기관(영문), 발행일자, 총페이지수, 주관부처명, 과제시작일, 보고서번호, 과제종료일, 주제분류, 키워드(한글), 전자원문, 키워드(영문), 입수제어번호, 초록(한글), 초록(영문), 목차
저장형식	Text(ASCII format) Excel format
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

2018년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2018 원문보기

초록 ▼

Abstract ▼

목차 Contents

표/그림 (300)

표/그림 (300)

연구자의 다른 보고서 :

참고문헌 (25)

연구과제 타임라인

관련 콘텐츠

원문 보기

이 보고서와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

2018년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구 Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2018 원문보기

초록 ▼

Abstract ▼

목차 Contents

표/그림 (300) 모든 표/그림 보기

표/그림 (300) 슬라이드로 보기

연구자의 다른 보고서 :

도정아 (38) 이상목 (26) 이정미 (27) 강희승 (42) 김도훈 (3) 홍순근 (8) 이영주 (17) 문귀임 (50)

참고문헌 (25)

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

이 보고서와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

2018년 식품 중 잔류농약 안전관리를 위한 위해평가 및 신규 시험법 확립 연구
Study on Safety Management by Risk Assessment & Analytical Method of Pesticide Residues in Foods - 2018 원문보기

표/그림 (300)

표/그림 (300)