Abstract ▼ AI-Helper

In search for plant-derived cytotoxic compounds, it was found that the EtOAc extracts a obtained from the root bark of Albizzia julibrissin Durazz exhibited significant cytotoxic activity against five human tumor cell lines, i.e ; A549, SK-OV-3. SK-MEL-2, XF498 and HCT15 in vitro. The structures and...

In search for plant-derived cytotoxic compounds, it was found that the EtOAc extracts a obtained from the root bark of Albizzia julibrissin Durazz exhibited significant cytotoxic activity against five human tumor cell lines, i.e ; A549, SK-OV-3. SK-MEL-2, XF498 and HCT15 in vitro. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including mp, [α]_(D^(25)), IR, UV, EI-MS, FAB-MS, 'H-NMR and ^(13)C-NMR spectra, and some chemical transformations as follows: compound 1 ((+)-euscaphic acid 28-glucopyronoside), compound 2 (luteolin-7-O- neohesperidoside), compound 3 (medioresinol), compound 4 (syringaresinol) and all compounds were isolated for the first time in this plant. Cytotoxic activity of compounds obtained from the root bark of Albizzia julibrissin Durazz on five tumor cells lines were was evaluated by procedure of SRB methods Compound 3 was significantly cytotoxic activity to the two human tumor cell lines (XF498, HCT15)

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