사카린 유도체는 제초제, 항독성, 살균제등에 광범위하게 연구되어져 오고있다. 새로운 농약 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-Cl) 2와 2-chloromethyl-1,2-benzisothiazol-3-one-1,1-dioxide 4를...
사카린 유도체는 제초제, 항독성, 살균제등에 광범위하게 연구되어져 오고있다. 새로운 농약 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-Cl) 2와 2-chloromethyl-1,2-benzisothiazol-3-one-1,1-dioxide 4를 합성하였다. 선도물질과 amines, imidazoles, triones등과 반응시켜 다음과 같은 물질들을 얻었다 ; 3-cyclohexylamino-1,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1- dioxide 8, 3-(3-imidazol)-1,2-benzisothiazol-1,1-dioxide 10, 3-(2-methyl-3-imidazol)-1,2-benzisothiazol-1,1-dioxide 12, 2-(3-imidazol)methyl-1,2-benzisothiazol-3-one-1,1-dioxide 13, 2-(3-imidazol)methyl-1,2-benzisothiazol-1,1-dioxide 14, 3-(2,3-dicarbomethoxy-7-oxobicyclo[2,2,1]hept-2,5-dienyl)methylamino-1,2-benzisothiazol-1,1- dioxide 24, 2-(1-methyl-2,4,5-imidazolidinetrionyl)-1,2-benzisothiazol-3-one-1,1-dioxide 25.
사카린 유도체는 제초제, 항독성, 살균제등에 광범위하게 연구되어져 오고있다. 새로운 농약 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-Cl) 2와 2-chloromethyl-1,2-benzisothiazol-3-one-1,1-dioxide 4를 합성하였다. 선도물질과 amines, imidazoles, triones등과 반응시켜 다음과 같은 물질들을 얻었다 ; 3-cyclohexylamino-1,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1- dioxide 8, 3-(3-imidazol)-1,2-benzisothiazol-1,1-dioxide 10, 3-(2-methyl-3-imidazol)-1,2-benzisothiazol-1,1-dioxide 12, 2-(3-imidazol)methyl-1,2-benzisothiazol-3-one-1,1-dioxide 13, 2-(3-imidazol)methyl-1,2-benzisothiazol-1,1-dioxide 14, 3-(2,3-dicarbomethoxy-7-oxobicyclo[2,2,1]hept-2,5-dienyl)methylamino-1,2-benzisothiazol-1,1- dioxide 24, 2-(1-methyl-2,4,5-imidazolidinetrionyl)-1,2-benzisothiazol-3-one-1,1-dioxide 25.
Saccharin derivatives have been widely studied for phytocides, herbicides, non-caloric sweetener, and pharmaceutic aid. In order to obtain new agricultural chemical product, lead compound was synthesized by chlorination of saccharin. 3-chloro-1,2-benzisothiazol-1,l-dioxide(BID-C1) and 2-chloromethyl...
Saccharin derivatives have been widely studied for phytocides, herbicides, non-caloric sweetener, and pharmaceutic aid. In order to obtain new agricultural chemical product, lead compound was synthesized by chlorination of saccharin. 3-chloro-1,2-benzisothiazol-1,l-dioxide(BID-C1) and 2-chloromethyl-1,2-benzisothiazol-3-one-1,1-dioxide were synthesized by oxidation and chlorination of saccharin. New synthesized saccharin derivatives by the treatment of 1,2-benzisothiazol-3-one-1,1-dioxide 1, 3-chloro-1,2-benzisothiazol-1,1-dioxide 2 are as follows； 3-cyclohexylamino-l,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1-dioxide 8, 3-(3-imidazolyl)-1,2-benzisothiazol-1,l-dioxide 10, 3-(2-methyl-3-imidazolyl)-1,2-benzisothiazol-1,1-dioxide 12, 2-(3-imidazolyl)methyl-1,2-benzisothiazol-3-one-1,1-dioxide 13, 2- (3-imidazoly1)methyl-1,2-benzisothiazo1-3-one-1,1-dioxide 14, 3-(2,3-dicarbomethoxy-7-oxobicyclo[2,2,1]hept-2,5-dienyl)methylamino -1,2-benzisothiazol-1,1-dioxide 24, and 2-(1-methyl-2,4,5-imidazolidinetrionyl)-1,2-benzisothiazol-3-one-1,1-dioxide 25.
Saccharin derivatives have been widely studied for phytocides, herbicides, non-caloric sweetener, and pharmaceutic aid. In order to obtain new agricultural chemical product, lead compound was synthesized by chlorination of saccharin. 3-chloro-1,2-benzisothiazol-1,l-dioxide(BID-C1) and 2-chloromethyl-1,2-benzisothiazol-3-one-1,1-dioxide were synthesized by oxidation and chlorination of saccharin. New synthesized saccharin derivatives by the treatment of 1,2-benzisothiazol-3-one-1,1-dioxide 1, 3-chloro-1,2-benzisothiazol-1,1-dioxide 2 are as follows； 3-cyclohexylamino-l,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1-dioxide 8, 3-(3-imidazolyl)-1,2-benzisothiazol-1,l-dioxide 10, 3-(2-methyl-3-imidazolyl)-1,2-benzisothiazol-1,1-dioxide 12, 2-(3-imidazolyl)methyl-1,2-benzisothiazol-3-one-1,1-dioxide 13, 2- (3-imidazoly1)methyl-1,2-benzisothiazo1-3-one-1,1-dioxide 14, 3-(2,3-dicarbomethoxy-7-oxobicyclo[2,2,1]hept-2,5-dienyl)methylamino -1,2-benzisothiazol-1,1-dioxide 24, and 2-(1-methyl-2,4,5-imidazolidinetrionyl)-1,2-benzisothiazol-3-one-1,1-dioxide 25.
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