The present study was performed to evaluate effects of octacosanol used as a health functional food on the endurance exercise performance in exercise-trained rats. Male Sprague Dawley rats were randomly assigned to one of the five groups; sedentary control group (SC, n=8), exercise-trained control g...
The present study was performed to evaluate effects of octacosanol used as a health functional food on the endurance exercise performance in exercise-trained rats. Male Sprague Dawley rats were randomly assigned to one of the five groups; sedentary control group (SC, n=8), exercise-trained control group (EC, n=16), exercise-trained and 0.02% octacosanol-supplemented group (0.02EO, n=16), exercise-trained and 0.12% octacosanol-supplemented group (0.12EO, n=16), exercise-trained and 1.2% octacosanol-supplemented group (1.2EO, n=16). Five groups were raised on control, 0.02%, 0.12% or 1.2% octacosanol (purity 5%) supplemented diet with (or without for SC rats) exercise-training for 6 weeks in a rodent treadmill. At the end of the experimental period, exercise-trained rats had been randomly divided into two groups and underwent exercise loading test until exhausted (n = 8) or exercise loading test for 1 h (n = 8) on a treadmill. EC rats run 255% longer on the treadmill until exhausted than the SC rats, while 0.02EO, 0.12EO or 1.2EO run 134%, 162% or 206% longer than the value of that for EC rats (p<0.05). Under the exhasuted state immediately following the endurance exercise performance test, 0.02EO, 0.12EO and 1.2EO rats exhibited significantly lower plasma ammonia and liver glycogen compared with the value for EC rats. Plasma lactate of rats fed 1.2% octacosanol supplementation significantly reduced by 11% compared to that of EC rats. 0.12EO or 1.2EO rats highly increased the level of plasma glucose by 18% or 24%, compared to that of 0.02EO rats (p<0.05). The inorganic phosphate in plasma and muscle citrate synthase activity in muscle were not significantly different among octacosanol supplemented groups. Following the 1h running workout, plasma ammonia concentration was significantly lower in 0.02%, 0.12% and 1.2% octacosanol supplemented groups compared to EC group. The liver glycogen concentration in octacosanol supplemented groups was significantly increased compared with that of EC rats. In particular, 1.2EO rats was increased by 59% (p<0.05). The concentration of muscle glycogen and activity of muscle citrate synthase in rats fed the octacosanol supplementation were significantly increased compared with those of EC group (p<0.05). These results suggest that 0.02%, 0.12%, and 1.2% (purity 5%) octacosanol appear to be effective in enhancing endurance exercise performance of trained rats.
The present study was performed to evaluate effects of octacosanol used as a health functional food on the endurance exercise performance in exercise-trained rats. Male Sprague Dawley rats were randomly assigned to one of the five groups; sedentary control group (SC, n=8), exercise-trained control group (EC, n=16), exercise-trained and 0.02% octacosanol-supplemented group (0.02EO, n=16), exercise-trained and 0.12% octacosanol-supplemented group (0.12EO, n=16), exercise-trained and 1.2% octacosanol-supplemented group (1.2EO, n=16). Five groups were raised on control, 0.02%, 0.12% or 1.2% octacosanol (purity 5%) supplemented diet with (or without for SC rats) exercise-training for 6 weeks in a rodent treadmill. At the end of the experimental period, exercise-trained rats had been randomly divided into two groups and underwent exercise loading test until exhausted (n = 8) or exercise loading test for 1 h (n = 8) on a treadmill. EC rats run 255% longer on the treadmill until exhausted than the SC rats, while 0.02EO, 0.12EO or 1.2EO run 134%, 162% or 206% longer than the value of that for EC rats (p<0.05). Under the exhasuted state immediately following the endurance exercise performance test, 0.02EO, 0.12EO and 1.2EO rats exhibited significantly lower plasma ammonia and liver glycogen compared with the value for EC rats. Plasma lactate of rats fed 1.2% octacosanol supplementation significantly reduced by 11% compared to that of EC rats. 0.12EO or 1.2EO rats highly increased the level of plasma glucose by 18% or 24%, compared to that of 0.02EO rats (p<0.05). The inorganic phosphate in plasma and muscle citrate synthase activity in muscle were not significantly different among octacosanol supplemented groups. Following the 1h running workout, plasma ammonia concentration was significantly lower in 0.02%, 0.12% and 1.2% octacosanol supplemented groups compared to EC group. The liver glycogen concentration in octacosanol supplemented groups was significantly increased compared with that of EC rats. In particular, 1.2EO rats was increased by 59% (p<0.05). The concentration of muscle glycogen and activity of muscle citrate synthase in rats fed the octacosanol supplementation were significantly increased compared with those of EC group (p<0.05). These results suggest that 0.02%, 0.12%, and 1.2% (purity 5%) octacosanol appear to be effective in enhancing endurance exercise performance of trained rats.
주제어
#건강기능식품
#옥타코사놀
#지구력 증진
#health functional food
#octacosanol
#endurance exercise performance
#exercise-trained rats
#glycogen
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