본 연구는 실험적으로 Type Ⅱ Collagen으로 유도한 류마티스관절염 백서에서 우슬과 전침자극의 효과를 알아보고자 하였다. 250 g의 수컷 백서를 5그룹으로 분류하여 류마티스관절염 유발후 28일 동안 실험하였으며, 류마티스관절염 유발없이 매일 0.9% NaCl 0.5 ㎖을 경구투여한 대조군, 류마티스관절염 유발 후 0.9% NaCl 0.5 ㎖을 식이한 실험군 Ⅰ, 류마티스관절염 유발 후 우슬 500 ㎎/㎏ 0.5 ㎖을 경구투여한 실험군 Ⅱ, 류마티스관절염 유발 후 ...
본 연구는 실험적으로 Type Ⅱ Collagen으로 유도한 류마티스관절염 백서에서 우슬과 전침자극의 효과를 알아보고자 하였다. 250 g의 수컷 백서를 5그룹으로 분류하여 류마티스관절염 유발후 28일 동안 실험하였으며, 류마티스관절염 유발없이 매일 0.9% NaCl 0.5 ㎖을 경구투여한 대조군, 류마티스관절염 유발 후 0.9% NaCl 0.5 ㎖을 식이한 실험군 Ⅰ, 류마티스관절염 유발 후 우슬 500 ㎎/㎏ 0.5 ㎖을 경구투여한 실험군 Ⅱ, 류마티스관절염 유발 후 족삼리(ST36)에 30분 동안 2 Hz의 전기자극을 실시한 실험군 Ⅲ, 류마티스관절염 유발 후 우슬 500 ㎎/㎏ 0.5 ㎖ 경구투여와 족삼리(ST36)에 30분 동안 2 Hz의 전기자극을 병용한 실험군 Ⅳ로 분류하였다. 류마티스관절염에 대한 우슬 및 전침자극의 효과를 알아보기 위해 족부종율과 관절염 지수평가, 혈액학적 분석(ALT, AST, WBC, CRP) 및 ELISA를 이용한 TNF-α 측정, H & E와 Safranin O-fast green 염색을 통한 조직학적 검사 등을 통하여 다음과 같은 결과를 얻었다. 첫째, 족부종율과 관절염 평가지수 소견은 실험군 Ⅰ, Ⅱ, Ⅲ, Ⅳ에서 유의한 감소가 있었으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 둘째, 혈액학적인 분석(ALT, AST, WBC, CRP) 결과 대조군에 비해 실험군 Ⅰ이 유의한 증가를 보였으며, 실험군 Ⅰ에 비해 실험군 Ⅱ, Ⅲ, Ⅳ에서 모두 유의한 감소가 있었으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 셋째, 조직학적인 소견은 실험군 Ⅱ, Ⅲ, Ⅳ에서 활액막의 비후, 염증세포들의 침윤, 관절연골 손상 등이 감소하였으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 넷째, TNF-α 소견은 대조군에 비해 실험군 Ⅰ이 유의한 증가를 보였으며, 실험군 Ⅰ에 비해 실험군 Ⅱ, Ⅲ, Ⅳ은 유의한 감소를 보였다. 그 중 실험군 Ⅳ이 가장 유의한 감소를 보였다(p<.05). 이상의 결과를 살펴보면 류마티스관절염 백서에 있어서 우슬투여와 전침자극이 관절 활액막의 비후, 염증세포들의 침윤정도의 변화와 관절연골 손상을 억제하여 결과적으로 류마티스관절염에 효과가 있을 것으로 사료된다.
본 연구는 실험적으로 Type Ⅱ Collagen으로 유도한 류마티스관절염 백서에서 우슬과 전침자극의 효과를 알아보고자 하였다. 250 g의 수컷 백서를 5그룹으로 분류하여 류마티스관절염 유발후 28일 동안 실험하였으며, 류마티스관절염 유발없이 매일 0.9% NaCl 0.5 ㎖을 경구투여한 대조군, 류마티스관절염 유발 후 0.9% NaCl 0.5 ㎖을 식이한 실험군 Ⅰ, 류마티스관절염 유발 후 우슬 500 ㎎/㎏ 0.5 ㎖을 경구투여한 실험군 Ⅱ, 류마티스관절염 유발 후 족삼리(ST36)에 30분 동안 2 Hz의 전기자극을 실시한 실험군 Ⅲ, 류마티스관절염 유발 후 우슬 500 ㎎/㎏ 0.5 ㎖ 경구투여와 족삼리(ST36)에 30분 동안 2 Hz의 전기자극을 병용한 실험군 Ⅳ로 분류하였다. 류마티스관절염에 대한 우슬 및 전침자극의 효과를 알아보기 위해 족부종율과 관절염 지수평가, 혈액학적 분석(ALT, AST, WBC, CRP) 및 ELISA를 이용한 TNF-α 측정, H & E와 Safranin O-fast green 염색을 통한 조직학적 검사 등을 통하여 다음과 같은 결과를 얻었다. 첫째, 족부종율과 관절염 평가지수 소견은 실험군 Ⅰ, Ⅱ, Ⅲ, Ⅳ에서 유의한 감소가 있었으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 둘째, 혈액학적인 분석(ALT, AST, WBC, CRP) 결과 대조군에 비해 실험군 Ⅰ이 유의한 증가를 보였으며, 실험군 Ⅰ에 비해 실험군 Ⅱ, Ⅲ, Ⅳ에서 모두 유의한 감소가 있었으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 셋째, 조직학적인 소견은 실험군 Ⅱ, Ⅲ, Ⅳ에서 활액막의 비후, 염증세포들의 침윤, 관절연골 손상 등이 감소하였으며, 특히 실험군 Ⅳ에서 가장 유의한 감소가 있었다(p<.05). 넷째, TNF-α 소견은 대조군에 비해 실험군 Ⅰ이 유의한 증가를 보였으며, 실험군 Ⅰ에 비해 실험군 Ⅱ, Ⅲ, Ⅳ은 유의한 감소를 보였다. 그 중 실험군 Ⅳ이 가장 유의한 감소를 보였다(p<.05). 이상의 결과를 살펴보면 류마티스관절염 백서에 있어서 우슬투여와 전침자극이 관절 활액막의 비후, 염증세포들의 침윤정도의 변화와 관절연골 손상을 억제하여 결과적으로 류마티스관절염에 효과가 있을 것으로 사료된다.
The purpose of this study was to observe the effects of Achyranthes Radix(AR) and electroacupuncture(EA) in rats with rheumatoid arthritis induced by type Ⅱ collagen. Male sprague-dawley rats weighing 250 g were divided into 5 groups: Control group was daily administered 0.9% NaCl 0.5 ㎖ to normal ra...
The purpose of this study was to observe the effects of Achyranthes Radix(AR) and electroacupuncture(EA) in rats with rheumatoid arthritis induced by type Ⅱ collagen. Male sprague-dawley rats weighing 250 g were divided into 5 groups: Control group was daily administered 0.9% NaCl 0.5 ㎖ to normal rats for 28 days, Experimental group I was daily administered 0.9% NaCl 0.5 ㎖ to arthritic rats for 28 days, Experimental group Ⅱ was orally administered with Achyranthes Radix 500 ㎎/㎏ 0.5 ㎖ to arthritic rats daily for 28 days. Experimental group Ⅲ was given 2 Hz electroacupuncture(EA) of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats for 28 days. Experimental group Ⅳ was daily orally administered with Achyranthes Radix 500 ㎎/㎏ 0.5 ㎖ and 2 Hz electroacupuncture(EA) of chok samni acupoint(ST36) in the test group for 30 min/daily to arthritic rats for 28 days. The author observed inhibitory effect of the hind paw edema, assessment of arthritis indices, analgetic effects by analysis of blood chemistry(WBC, CRP, ALT, AST) and histopathological changes by hematoxylin-eosin and safranin O-fast green stain and ELSIA of cytokines(TNF-?). The results were as follows: 1. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased the rate of paw edema compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased the edema rate. 2. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased arthritis indices compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased arthritis indices. 3. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased WBC(White blood cell) compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased. 4. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased CRP(C reactive protein) compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased. 5. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased AST(Asparatate transaminase) and ALT(Alanine transaminase) compared with Experimental group Ⅰ and only Experimental group Ⅳ was the most significantly decreased. 6. Experimental group Ⅱ, Ⅲ, Ⅳ were relieved and reproduced the erosion of arthritic site compared with Experimental group Ⅰ. Experimental group Ⅳ was the most effective compared with experimental group Ⅱ, Ⅲ with naked eye on the histopathological view. 7. Experimental group Ⅱ, Ⅲ, Ⅳ were the inflammation component at synovial capsule decreased more than Experimental group Ⅰ. Experimental group Ⅳ was the most significantly increased in collagen fiber at synovial capsule. 8. In the ELSIA test of TNF-α concentration, Experimental group Ⅰ significantly increased in the concentration more than experimental group Ⅱ, Ⅲ, Ⅳ. The rate of increase in concentration slowed down in Experimental group Ⅳ more than experimental group Ⅱ, Ⅲ. The above results indicate that Achyranthes Radix and electroacupuncture can be used for a treatment of rheumatoid arthritis. It would be considered that Achyranthes Radix has an effect on relieving rheumatoid arthritis.
The purpose of this study was to observe the effects of Achyranthes Radix(AR) and electroacupuncture(EA) in rats with rheumatoid arthritis induced by type Ⅱ collagen. Male sprague-dawley rats weighing 250 g were divided into 5 groups: Control group was daily administered 0.9% NaCl 0.5 ㎖ to normal rats for 28 days, Experimental group I was daily administered 0.9% NaCl 0.5 ㎖ to arthritic rats for 28 days, Experimental group Ⅱ was orally administered with Achyranthes Radix 500 ㎎/㎏ 0.5 ㎖ to arthritic rats daily for 28 days. Experimental group Ⅲ was given 2 Hz electroacupuncture(EA) of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats for 28 days. Experimental group Ⅳ was daily orally administered with Achyranthes Radix 500 ㎎/㎏ 0.5 ㎖ and 2 Hz electroacupuncture(EA) of chok samni acupoint(ST36) in the test group for 30 min/daily to arthritic rats for 28 days. The author observed inhibitory effect of the hind paw edema, assessment of arthritis indices, analgetic effects by analysis of blood chemistry(WBC, CRP, ALT, AST) and histopathological changes by hematoxylin-eosin and safranin O-fast green stain and ELSIA of cytokines(TNF-?). The results were as follows: 1. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased the rate of paw edema compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased the edema rate. 2. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased arthritis indices compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased arthritis indices. 3. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased WBC(White blood cell) compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased. 4. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased CRP(C reactive protein) compared with Experimental group Ⅰ. Experimental group Ⅳ was the most significantly decreased. 5. Experimental group Ⅱ, Ⅲ, Ⅳ were significantly decreased AST(Asparatate transaminase) and ALT(Alanine transaminase) compared with Experimental group Ⅰ and only Experimental group Ⅳ was the most significantly decreased. 6. Experimental group Ⅱ, Ⅲ, Ⅳ were relieved and reproduced the erosion of arthritic site compared with Experimental group Ⅰ. Experimental group Ⅳ was the most effective compared with experimental group Ⅱ, Ⅲ with naked eye on the histopathological view. 7. Experimental group Ⅱ, Ⅲ, Ⅳ were the inflammation component at synovial capsule decreased more than Experimental group Ⅰ. Experimental group Ⅳ was the most significantly increased in collagen fiber at synovial capsule. 8. In the ELSIA test of TNF-α concentration, Experimental group Ⅰ significantly increased in the concentration more than experimental group Ⅱ, Ⅲ, Ⅳ. The rate of increase in concentration slowed down in Experimental group Ⅳ more than experimental group Ⅱ, Ⅲ. The above results indicate that Achyranthes Radix and electroacupuncture can be used for a treatment of rheumatoid arthritis. It would be considered that Achyranthes Radix has an effect on relieving rheumatoid arthritis.
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