The primary purpose of this study was done to assess the relationship between the intakes of Ca&Vit.D and insulin secretion, and intakes of Ca& Vit.D and blood glucose, other purpose was done to assess effects of Vit. D and Ca intervention on blood glucose and insulin secretion level in Korean patie...
The primary purpose of this study was done to assess the relationship between the intakes of Ca&Vit.D and insulin secretion, and intakes of Ca& Vit.D and blood glucose, other purpose was done to assess effects of Vit. D and Ca intervention on blood glucose and insulin secretion level in Korean patients with type 2 diabetes mellitus (DM). The experiment 1 on this study that the patients were divided into 4 groups according to their serum level 25(OH)D₃ and divided into 3 groups according to their Ca intake level. We conducted an observational study in 54 type 2 diabetic patients in order to assess the prevalence of hypovitaminosis D and dietary calcium insufficiency. The experiment 2 in this study was that the patients were practiced medical nutrition therapy about Vit.D and Ca intake intervention. The clinical study was a randomized placebo-controlled trial and a total 54 type 2 DM patients divided into two treatment groups, MNT group (n=14, Ca and Vit.D intervention for 12 weeks as a experimental group) and control group (n=12, No treatment for 12 weeks as a control). After a week washing-out period, fasting blood glucose, HbA1C, serum 25(OH)D₃, serum lipid levels, insulin secretion, activity time and dietary survey were analyzed before and after treatment. The age, activity time, percentage of ideal body weight and serum level 25(OH)D₃ of the patients were similar in the two groups, and the eating habits and nutrient intake were also not significantly different. The results were as follows: Ca intake in male was 92.05±24.89% of RI and 72.24±23.78% of RI in female. In most of age groups, Ca intake was above 75% of RI but in over 65 age female group, Ca intake was very insufficient with 64.15±20.19% of RI and those who take Ca below EAR were also 33.33% to 77.77% except for over 65 age in male group. Vit.D intake in male who had 81.06±24.29% of AI was more than in female who had 62.72±26.17% of AI. Vit.D intake by age didn't satisfy AI in all age group. Especially it was very insufficient with 44.54±24.61% of AI in over 65 age male group. The 63% of patients being Vit.D deficient and high prevalence of 25(OH)D₃ deficiency was higher portion of type 2 diabetes in female patients than in the male. Serum 25(OH)D₃ level was negatively correlated with insulin resistance and blood glucose. Ca intake level was negatively correlated with insulin resistance and obesity. Low Ca and Vit.D levels may be risk factors for insulin secretion and insulin resistance. The concentrations of total cholesterol and LDL-cholesterol decreased significantly (p<0.05) in MNT group after the intervention for 12 weeks, and the concentrations of triglyceride decreased, while there was no change in the control group. The fasting blood glucose and HbA1C concentrations decreased significantly (p<0.05) after Vit.D and Ca intake intervention in MNT groups, while there was no change in the control group. Dietary calcium and dietary Vit.D intakes were significantly(p<0.05) higher in the MNT group than in the control group. The weight and waist circumference decreased significantly (p<0.05) in the MNT group after the intervention for 12 weeks, while there was no change in the control group. The concentrations of serum 25(OH)D₃ and insulin secretion increased slightly in the MNT group after the intervention for 12 weeks, and HOMAIR decreased significantly (p<0.05), while there was no change in the control group. It showed that Ca and Vit.D intake intervention for 12 weeks decreased significantly (p<0.05) the fasting blood glucose and HbA1C concentrations in the MNT group, and also decreased HOMAIR. These results indicated that could be effective Ca and Vit.D intervention in improving blood glucose, HbA1C, serum 25(OH)D₃ and HOMAIR in patients with type 2 Diabetes Mellitus who have insufficient of serum level 25(OH)D₃ concentrations. This study is excepted to be a small step to improvement of the type 2 diabetes mellitus.
The primary purpose of this study was done to assess the relationship between the intakes of Ca&Vit.D and insulin secretion, and intakes of Ca& Vit.D and blood glucose, other purpose was done to assess effects of Vit. D and Ca intervention on blood glucose and insulin secretion level in Korean patients with type 2 diabetes mellitus (DM). The experiment 1 on this study that the patients were divided into 4 groups according to their serum level 25(OH)D₃ and divided into 3 groups according to their Ca intake level. We conducted an observational study in 54 type 2 diabetic patients in order to assess the prevalence of hypovitaminosis D and dietary calcium insufficiency. The experiment 2 in this study was that the patients were practiced medical nutrition therapy about Vit.D and Ca intake intervention. The clinical study was a randomized placebo-controlled trial and a total 54 type 2 DM patients divided into two treatment groups, MNT group (n=14, Ca and Vit.D intervention for 12 weeks as a experimental group) and control group (n=12, No treatment for 12 weeks as a control). After a week washing-out period, fasting blood glucose, HbA1C, serum 25(OH)D₃, serum lipid levels, insulin secretion, activity time and dietary survey were analyzed before and after treatment. The age, activity time, percentage of ideal body weight and serum level 25(OH)D₃ of the patients were similar in the two groups, and the eating habits and nutrient intake were also not significantly different. The results were as follows: Ca intake in male was 92.05±24.89% of RI and 72.24±23.78% of RI in female. In most of age groups, Ca intake was above 75% of RI but in over 65 age female group, Ca intake was very insufficient with 64.15±20.19% of RI and those who take Ca below EAR were also 33.33% to 77.77% except for over 65 age in male group. Vit.D intake in male who had 81.06±24.29% of AI was more than in female who had 62.72±26.17% of AI. Vit.D intake by age didn't satisfy AI in all age group. Especially it was very insufficient with 44.54±24.61% of AI in over 65 age male group. The 63% of patients being Vit.D deficient and high prevalence of 25(OH)D₃ deficiency was higher portion of type 2 diabetes in female patients than in the male. Serum 25(OH)D₃ level was negatively correlated with insulin resistance and blood glucose. Ca intake level was negatively correlated with insulin resistance and obesity. Low Ca and Vit.D levels may be risk factors for insulin secretion and insulin resistance. The concentrations of total cholesterol and LDL-cholesterol decreased significantly (p<0.05) in MNT group after the intervention for 12 weeks, and the concentrations of triglyceride decreased, while there was no change in the control group. The fasting blood glucose and HbA1C concentrations decreased significantly (p<0.05) after Vit.D and Ca intake intervention in MNT groups, while there was no change in the control group. Dietary calcium and dietary Vit.D intakes were significantly(p<0.05) higher in the MNT group than in the control group. The weight and waist circumference decreased significantly (p<0.05) in the MNT group after the intervention for 12 weeks, while there was no change in the control group. The concentrations of serum 25(OH)D₃ and insulin secretion increased slightly in the MNT group after the intervention for 12 weeks, and HOMAIR decreased significantly (p<0.05), while there was no change in the control group. It showed that Ca and Vit.D intake intervention for 12 weeks decreased significantly (p<0.05) the fasting blood glucose and HbA1C concentrations in the MNT group, and also decreased HOMAIR. These results indicated that could be effective Ca and Vit.D intervention in improving blood glucose, HbA1C, serum 25(OH)D₃ and HOMAIR in patients with type 2 Diabetes Mellitus who have insufficient of serum level 25(OH)D₃ concentrations. This study is excepted to be a small step to improvement of the type 2 diabetes mellitus.
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