Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases in childhood. Although the etiology of AD is still unknown, the pathogenesis is related to the immunoglobulin (Ig) E-mediated hypersensitivity and the delayed type hypersensitivity due to activated T lymphocytes. An ...
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases in childhood. Although the etiology of AD is still unknown, the pathogenesis is related to the immunoglobulin (Ig) E-mediated hypersensitivity and the delayed type hypersensitivity due to activated T lymphocytes. An early AD phase that is associated with a predominance of Th2 cytokine, is followed by a chronic inflammation associated with increased production of interleukin (IL)-5 and eosinophil infiltration. Recently, mulberry leaves (Morus alba L.), the feed for silkworm, have been reported to possess many medicinal properties such as anti-inflammatory, anti-hypertensive, anti-pyretic and hypoglycemic effects. In this study, the effect of the mulberry leaf extract (ME) was investigated on AD-like skin lesions in NC/Nga mice, which are characterized by the spontaneous onset of atopic dermatitis in conventional conditions. Induction of AD-like skin lesions were performed by topical application of 2,4-dinitrochlorobenzene (DNCB) and the effect was evaluated by histological analysis, serum IgE concentration, cytokine analysis and the number of Staphylococcus aureus. Histopathologic study showed that ME treatment decreased the thickness of epidermis, inflammatory cells in dermis of the ear and dorsal skin lesions and the number of S. aureus. The serum IgE level was also suppressed in ME-treated groups. Activated spleen cells from ME-treated mice exhibited a reduced capacity to produce IL-4, IL-5, IL-6, IL-10 and IL-17 compared with the control group. IL-2 was significantly increased in ME-treated groups. However, INF-γ was not significantly increased in ME-treated group. Taken together, these results suggest that ME has some inhibitory effects on the development of AD-like skin lesions in NC/Nga mice.
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases in childhood. Although the etiology of AD is still unknown, the pathogenesis is related to the immunoglobulin (Ig) E-mediated hypersensitivity and the delayed type hypersensitivity due to activated T lymphocytes. An early AD phase that is associated with a predominance of Th2 cytokine, is followed by a chronic inflammation associated with increased production of interleukin (IL)-5 and eosinophil infiltration. Recently, mulberry leaves (Morus alba L.), the feed for silkworm, have been reported to possess many medicinal properties such as anti-inflammatory, anti-hypertensive, anti-pyretic and hypoglycemic effects. In this study, the effect of the mulberry leaf extract (ME) was investigated on AD-like skin lesions in NC/Nga mice, which are characterized by the spontaneous onset of atopic dermatitis in conventional conditions. Induction of AD-like skin lesions were performed by topical application of 2,4-dinitrochlorobenzene (DNCB) and the effect was evaluated by histological analysis, serum IgE concentration, cytokine analysis and the number of Staphylococcus aureus. Histopathologic study showed that ME treatment decreased the thickness of epidermis, inflammatory cells in dermis of the ear and dorsal skin lesions and the number of S. aureus. The serum IgE level was also suppressed in ME-treated groups. Activated spleen cells from ME-treated mice exhibited a reduced capacity to produce IL-4, IL-5, IL-6, IL-10 and IL-17 compared with the control group. IL-2 was significantly increased in ME-treated groups. However, INF-γ was not significantly increased in ME-treated group. Taken together, these results suggest that ME has some inhibitory effects on the development of AD-like skin lesions in NC/Nga mice.
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