Boehmeria pannosa extract has been reported to contain therapeutic compounds for treating diabetes mellitus, cancer or neurodegenerative diseases. Stauntonia hexaphylla extract has been investigated for their elastase and tyrosinase inhibitory activity. However, there has been no previous report on ...
Boehmeria pannosa extract has been reported to contain therapeutic compounds for treating diabetes mellitus, cancer or neurodegenerative diseases. Stauntonia hexaphylla extract has been investigated for their elastase and tyrosinase inhibitory activity. However, there has been no previous report on their cytotoxic activity on colon cancer cell.
In our continuing search for cytotoxic agents from plants, B. pannosa and S. hexaphylla have been selected for further investigation based on the initial screening results. The aerial part of B. pannosa was extracted with 100% MeOH and partitioned with HD, DE, E, EM in sequence. The cytotoxic activity-guided fractionation of EM extract from B. pannosa led to the isolation of four compounds, betulin (1), cholesterol (2), β-sitosterol (3), and kaempferol 3-O-β-D-glucoside (4). The leaves and stems of S. hexaphylla were extracted with 100% MeOH and the concentrated extract was successively partitioned with HD, DE, E, EM, respectively. Cytotoxic activity-guided fractionation of E extract from S. hexaphylla led to the isolation of two compounds, hederagenin 3-O-α-L-arabinoside (5), and quercetin (6). The structures of these compounds were elucidated by spectroscopic methods, including UV, IR, MS, NMR techniques and comparing with the previous data. The cytotoxic activities of these compounds were also evaluated, and compounds (4), (5) and (6) showed higher cytotoxic activities.
Boehmeria pannosa extract has been reported to contain therapeutic compounds for treating diabetes mellitus, cancer or neurodegenerative diseases. Stauntonia hexaphylla extract has been investigated for their elastase and tyrosinase inhibitory activity. However, there has been no previous report on their cytotoxic activity on colon cancer cell.
In our continuing search for cytotoxic agents from plants, B. pannosa and S. hexaphylla have been selected for further investigation based on the initial screening results. The aerial part of B. pannosa was extracted with 100% MeOH and partitioned with HD, DE, E, EM in sequence. The cytotoxic activity-guided fractionation of EM extract from B. pannosa led to the isolation of four compounds, betulin (1), cholesterol (2), β-sitosterol (3), and kaempferol 3-O-β-D-glucoside (4). The leaves and stems of S. hexaphylla were extracted with 100% MeOH and the concentrated extract was successively partitioned with HD, DE, E, EM, respectively. Cytotoxic activity-guided fractionation of E extract from S. hexaphylla led to the isolation of two compounds, hederagenin 3-O-α-L-arabinoside (5), and quercetin (6). The structures of these compounds were elucidated by spectroscopic methods, including UV, IR, MS, NMR techniques and comparing with the previous data. The cytotoxic activities of these compounds were also evaluated, and compounds (4), (5) and (6) showed higher cytotoxic activities.
주제어
#Chemical Constituents
#Boehmeria pannosa
#Stauntonia hexaphylla
#Cytotoxicity
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