Abstract A randomized, Double-blind, Clinical Trial of Donepezil in Patients with Aneurysmal Subarachnoid Hemorrhage Jang Bok Lee, M.D. Department of Physical and Rehabilitation Medicine, Soonchunhyang University, School of Medicine, Seoul, Korea (supervised by Professor Yang Gyun Lee) Patients with...
Abstract A randomized, Double-blind, Clinical Trial of Donepezil in Patients with Aneurysmal Subarachnoid Hemorrhage Jang Bok Lee, M.D. Department of Physical and Rehabilitation Medicine, Soonchunhyang University, School of Medicine, Seoul, Korea (supervised by Professor Yang Gyun Lee) Patients with a ruptured and surgically repaired aneurysm often suffer from long-lasting cognitive deficits, which are associated with functional disability and poor quality of life. The purpose of this study was to evaluate the effects of donepezil administration in patients with aneurysmal subarachnoid hemorrhage (SAH). This investigation was a randomized, double-blind, 4-week study conducted from January 2008 to March 2011. A total of 243 patients were transferred to rehabilitation department when they became neurologically stable after aneurysmal SAH. Twenty four patients out of the 243 had spontaneous SAH from the rupture of the solitary aneurysm which was totally excluded by surgically neck clipping, and no major postoperative complications. They were randomized 1:1 to receive donepezil 5 mg/day or control, and memory functions were assessed by using mini-mental state examination (MMSE) and computerized neuropsychological test (CNT) before and after donepezil administration. There were no differences in age, education, Hunt and Hess grade, Fisher grade, mean initial test time after SAH, and sites of ruptured intracranial aneurysms, between the donepezil group and the control group. Compared with the control group, the donepezil group showed a significant improvement in forward digit span (P=0.03), second (P=0.02), third (P=0.04), fourth trial (P=0.00), recognition (P=0.04) in verbal learning test, and backward visual span (P=0.02), and first (P=0.01), second (P=0.02), third (P=0.03), fourth trial (P=0.03) of the visual learning test. Treatment options to improve cognitive impairments after the occurrence of an aneurysmal rupture are strongly needed. Patients treated with 5 mg/day donepezil demonstrated significant improvement in cognitive function based on CNT studies. Donepezil administration may improve memory functions in patients suffering from cognitive deficits caused by aneurysmal SAH.
Abstract A randomized, Double-blind, Clinical Trial of Donepezil in Patients with Aneurysmal Subarachnoid Hemorrhage Jang Bok Lee, M.D. Department of Physical and Rehabilitation Medicine, Soonchunhyang University, School of Medicine, Seoul, Korea (supervised by Professor Yang Gyun Lee) Patients with a ruptured and surgically repaired aneurysm often suffer from long-lasting cognitive deficits, which are associated with functional disability and poor quality of life. The purpose of this study was to evaluate the effects of donepezil administration in patients with aneurysmal subarachnoid hemorrhage (SAH). This investigation was a randomized, double-blind, 4-week study conducted from January 2008 to March 2011. A total of 243 patients were transferred to rehabilitation department when they became neurologically stable after aneurysmal SAH. Twenty four patients out of the 243 had spontaneous SAH from the rupture of the solitary aneurysm which was totally excluded by surgically neck clipping, and no major postoperative complications. They were randomized 1:1 to receive donepezil 5 mg/day or control, and memory functions were assessed by using mini-mental state examination (MMSE) and computerized neuropsychological test (CNT) before and after donepezil administration. There were no differences in age, education, Hunt and Hess grade, Fisher grade, mean initial test time after SAH, and sites of ruptured intracranial aneurysms, between the donepezil group and the control group. Compared with the control group, the donepezil group showed a significant improvement in forward digit span (P=0.03), second (P=0.02), third (P=0.04), fourth trial (P=0.00), recognition (P=0.04) in verbal learning test, and backward visual span (P=0.02), and first (P=0.01), second (P=0.02), third (P=0.03), fourth trial (P=0.03) of the visual learning test. Treatment options to improve cognitive impairments after the occurrence of an aneurysmal rupture are strongly needed. Patients treated with 5 mg/day donepezil demonstrated significant improvement in cognitive function based on CNT studies. Donepezil administration may improve memory functions in patients suffering from cognitive deficits caused by aneurysmal SAH.
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