In an effort to develop novel electrocatalysts to fabricate biosensors associated with the effective design, testing, and fabrication for health care purposes, we have successfully synthesized some novel metal NPs/GR nanohybrids for glucose, dopamine (DA), hydrogen peroxide (H2O2) and epinephrine (E...
In an effort to develop novel electrocatalysts to fabricate biosensors associated with the effective design, testing, and fabrication for health care purposes, we have successfully synthesized some novel metal NPs/GR nanohybrids for glucose, dopamine (DA), hydrogen peroxide (H2O2) and epinephrine (EP) determination in blood serum.
For the measurement of glucose and DA in bodily fluids with high selectivity and sensitivity to control diabetes mellitus, schizophrenia, Parkinson’s, and Alzheimer’s diseases, novel AuNPs attached graphene nanohybrids have been successfully synthesized. At first, the AuNPs encapsulated few-layer GR (AuNP-FLG) nanohybrids has been synthesized by chemical vapor deposition (CVD) technique. The AuNP-FLG displayed an excellent electrocatalytic activity towards glucose oxidation with a wide linear detection range of 6 M ~ 28.5 mM, low LOD of 1 M and a sensitivity of 0.195 A mM1 cm2 at operating potential of 0.0 V with long-term stability (retention of 95.4% after two weeks) and negligible interference. Besides, an effective electrocatalyst based on AuNPs anchored nitrogen-doped GR (AuNP/NG) nanohybrid was also prepared through a seed-assisted growth method. The nanohybrid exhibited excellent catalytic activity toward glucose, with a linear response throughout the concentration range from 40 M to 16.1 mM, a LOD of 12 M, and a short response time ( 10 s). Also, it exhibited an excellent response toward DA, with a wide detection range from 30 nM to 48 μM, a low LOD of 10 nM, and a short response time ( 8 s).
We have successfully synthesized porous bimetallic nanoalloy network-supported GR nanohybrids via electroless deposition followed by CVD method for the first time. As a continuous, porous, transparent, bendable, and thin film, these nanohybrids have large electroactive surface area and low charge transfer resistance, implying extremely high potential for biosensor applications. In particular, nanoporous AuPd alloy-supported graphene (AuPd@GR) nanohybrid exhibited excellent catalytic activity towards H2O2 detection with wide detection range (5 M - 11.5 mM), high sensitivity (188.64 A mM-1 cm-2), low LOD (1 M), fast response (3 seconds), and long-term amperometric stability (2500 s) with long durability along with negligible interferents. Another hierarchical nanoporous structure based on the AuPt nanoalloy-embedded GR (AuPt@GR) was successfully fabricated as well and then was used as binder-free sensor towards epinephrine (EP) with extremely low LOD of 0.9 nM (S/N = 3), high sensitivity of 1628 A mM-1 cm-2, wide linear detection range from 1.5 x 10-9 to 9.6 x10-6 M, and negligible response towards interferents. At the same time, the sensor also exhibited very long-term amperometric stability (4000 s), cyclic voltammetry (CV) stability (500 cycles), good reproducibility, and high accurate detection of EP in real samples. The obtained results suggest a large potential of these nanoporous hybrids to apply for fabricating biosensors and bioelectronic devices.
In an effort to develop novel electrocatalysts to fabricate biosensors associated with the effective design, testing, and fabrication for health care purposes, we have successfully synthesized some novel metal NPs/GR nanohybrids for glucose, dopamine (DA), hydrogen peroxide (H2O2) and epinephrine (EP) determination in blood serum.
For the measurement of glucose and DA in bodily fluids with high selectivity and sensitivity to control diabetes mellitus, schizophrenia, Parkinson’s, and Alzheimer’s diseases, novel AuNPs attached graphene nanohybrids have been successfully synthesized. At first, the AuNPs encapsulated few-layer GR (AuNP-FLG) nanohybrids has been synthesized by chemical vapor deposition (CVD) technique. The AuNP-FLG displayed an excellent electrocatalytic activity towards glucose oxidation with a wide linear detection range of 6 M ~ 28.5 mM, low LOD of 1 M and a sensitivity of 0.195 A mM1 cm2 at operating potential of 0.0 V with long-term stability (retention of 95.4% after two weeks) and negligible interference. Besides, an effective electrocatalyst based on AuNPs anchored nitrogen-doped GR (AuNP/NG) nanohybrid was also prepared through a seed-assisted growth method. The nanohybrid exhibited excellent catalytic activity toward glucose, with a linear response throughout the concentration range from 40 M to 16.1 mM, a LOD of 12 M, and a short response time ( 10 s). Also, it exhibited an excellent response toward DA, with a wide detection range from 30 nM to 48 μM, a low LOD of 10 nM, and a short response time ( 8 s).
We have successfully synthesized porous bimetallic nanoalloy network-supported GR nanohybrids via electroless deposition followed by CVD method for the first time. As a continuous, porous, transparent, bendable, and thin film, these nanohybrids have large electroactive surface area and low charge transfer resistance, implying extremely high potential for biosensor applications. In particular, nanoporous AuPd alloy-supported graphene (AuPd@GR) nanohybrid exhibited excellent catalytic activity towards H2O2 detection with wide detection range (5 M - 11.5 mM), high sensitivity (188.64 A mM-1 cm-2), low LOD (1 M), fast response (3 seconds), and long-term amperometric stability (2500 s) with long durability along with negligible interferents. Another hierarchical nanoporous structure based on the AuPt nanoalloy-embedded GR (AuPt@GR) was successfully fabricated as well and then was used as binder-free sensor towards epinephrine (EP) with extremely low LOD of 0.9 nM (S/N = 3), high sensitivity of 1628 A mM-1 cm-2, wide linear detection range from 1.5 x 10-9 to 9.6 x10-6 M, and negligible response towards interferents. At the same time, the sensor also exhibited very long-term amperometric stability (4000 s), cyclic voltammetry (CV) stability (500 cycles), good reproducibility, and high accurate detection of EP in real samples. The obtained results suggest a large potential of these nanoporous hybrids to apply for fabricating biosensors and bioelectronic devices.
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#Graphene chemical vapor deposition noble metal nanoparticle electrocatalyst sensor
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