초록 ▼

용어보기논문에서 용어와 풀이말을 자동 추출한 결과로, 시범 서비스 중입니다. AI-Helper

합환피 추출물이 지방세포 분화와 지방분해에 미치는 효과를 조사하여 다음과 같은 결론을 얻었다.
1. 합환피 추출물은 지방세포 분화를 유의하게 억제하였다.
2. 합환피 추출물의 지방세포 분화 억제 기전에 C/EBPβ 인산화 억제에 의한 PPARγ, C/EBPα...

합환피 추출물이 지방세포 분화와 지방분해에 미치는 효과를 조사하여 다음과 같은 결론을 얻었다.
1. 합환피 추출물은 지방세포 분화를 유의하게 억제하였다.
2. 합환피 추출물의 지방세포 분화 억제 기전에 C/EBPβ 인산화 억제에 의한 PPARγ, C/EBPα 발현 감소가 포함되어 있다.
3. 합환피 추출물은 지방세포의 지방분해를 촉진하였다.
4. 합환피 추출물의 지방분해 촉진 기전에 PKA 활성화에 의한 HSL의 인산화가 관여하였다.
이상의 결과는 합환피 추출물이 지방세포 분화 억제 및 지방 분해 촉진을 통한 항비만 제제 개발의 한 후보 물질이 될 수 있는 실험적 근거를 제시한 것으로 사료된다.

Abstract ▼ AI-Helper

In this study, Albizziae Cortex extracts (ACE) have potent effects on adipogenesis and on lipolysis in OP9 cells. There was no cytotoxicity while cells were treated with ACE in designated time intervals, unaffected by various concentrations.
In the cells with ACE-treated, increases in fat stora...

In this study, Albizziae Cortex extracts (ACE) have potent effects on adipogenesis and on lipolysis in OP9 cells. There was no cytotoxicity while cells were treated with ACE in designated time intervals, unaffected by various concentrations.
In the cells with ACE-treated, increases in fat storage were inhibited, and also confirmed by Oil red O. To understand the underlying mechanism at the molecular level, the effects of ACE were examined on the expression of the genes involved in adipogenesis by using real-time PCR. In this cell model, the mRNA level of adipogenic genes such as peroxisome-proliferator-activated receptors gamma (PPARγ) and CAAAT/enhancer binding protein alpha (C/EBPα) were decreased by ACE treatment, comparing with those of control group.
In the cells with ACE-treated, lipolysis was increased, which was confirmed by glycerol release measurements in the medium. To determine the mechanism for it, we performed inhibition test and found that ACE may stimulate the induction of hormone-sensitive lipose phosphorylation through protein kinase A signal pathway.
Collectively, our data suggest that ACE may have great potential as a novel anti-obesity agent.