Cirsium japonicum is a biennial or perennial herb belonging to Compositae family. Its roots and aerial parts have been used for the treatment of hematuria, hematemesis, hepatitis and hypertension. Several chemical constituents such as flavonoids and phenypropanoids have been reported from C. japonic...
Cirsium japonicum is a biennial or perennial herb belonging to Compositae family. Its roots and aerial parts have been used for the treatment of hematuria, hematemesis, hepatitis and hypertension. Several chemical constituents such as flavonoids and phenypropanoids have been reported from C. japonicum. Antioxidant, anti-obesity and tyrosinase inhibitory activity were tested to search for another biological activity of C. japonicum. The total methanolic extract was partitioned with n-hexane, CH2Cl2,, EtOAc, n-BuOH and H2O. The CH2Cl2-soluble fraction and EtOAc-soluble fraction of C. japonicum roots showed significant antioxidant and tyrosinase inhibitory activity. Further fractionation of CH2Cl2 and EtOAc-soluble fractions resulted in the isolation of five phenolic compounds, protocatechualdehyde (1), vanillin (2), 4-hydroxybenzoic acid (3), isoferulic acid (4),
naringenic acid (5), four flavonoids, acacetin (6), pectolinarigenin (7), hispidulin (8), 5,7-dihydroxy-8-methoxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (9), one coumarin, 6-(3,3-dimethylallyloxy)-7-methoxycoumarin (10), one lignan, 3-(3,4-dihydroxyphenyl)-6-(4-hydroxy-3.5-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan1-one (11). Their structures were elucidated on the basis of spectroscopic methods such as 1D-NMR (1H, 13C), 2D-NMR (HSQC, HMBC, NOESY) and ESI-MS. Among the isolated compounds, compounds 1, 4 and 11 showed antioxidant activity. Moreover compounds 1, 8 and 9 showed inhibitory effects on tyrosinase activity. These results showed that the roots of C. japonicum might be developed as antioxidant and whitening product.
Cirsium japonicum is a biennial or perennial herb belonging to Compositae family. Its roots and aerial parts have been used for the treatment of hematuria, hematemesis, hepatitis and hypertension. Several chemical constituents such as flavonoids and phenypropanoids have been reported from C. japonicum. Antioxidant, anti-obesity and tyrosinase inhibitory activity were tested to search for another biological activity of C. japonicum. The total methanolic extract was partitioned with n-hexane, CH2Cl2,, EtOAc, n-BuOH and H2O. The CH2Cl2-soluble fraction and EtOAc-soluble fraction of C. japonicum roots showed significant antioxidant and tyrosinase inhibitory activity. Further fractionation of CH2Cl2 and EtOAc-soluble fractions resulted in the isolation of five phenolic compounds, protocatechualdehyde (1), vanillin (2), 4-hydroxybenzoic acid (3), isoferulic acid (4),
naringenic acid (5), four flavonoids, acacetin (6), pectolinarigenin (7), hispidulin (8), 5,7-dihydroxy-8-methoxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (9), one coumarin, 6-(3,3-dimethylallyloxy)-7-methoxycoumarin (10), one lignan, 3-(3,4-dihydroxyphenyl)-6-(4-hydroxy-3.5-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan1-one (11). Their structures were elucidated on the basis of spectroscopic methods such as 1D-NMR (1H, 13C), 2D-NMR (HSQC, HMBC, NOESY) and ESI-MS. Among the isolated compounds, compounds 1, 4 and 11 showed antioxidant activity. Moreover compounds 1, 8 and 9 showed inhibitory effects on tyrosinase activity. These results showed that the roots of C. japonicum might be developed as antioxidant and whitening product.
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