A Study on the Efficacy and Toxicity of Rhus chinensis extract as a Cosmetic Material
Seung-Jin Jung
Department of Cosmetic Science, The Gradute School
Hoseo University
Asan, Korea
(Supervised by professor Jin-Young Lee)
The purpose of this study is to inv...
A Study on the Efficacy and Toxicity of Rhus chinensis extract as a Cosmetic Material
Seung-Jin Jung
Department of Cosmetic Science, The Gradute School
Hoseo University
Asan, Korea
(Supervised by professor Jin-Young Lee)
The purpose of this study is to investigate whether Rhus chinensis extract can be used as a cosmetic raw material. The electron donating ability of 70% ethanol extract from Rhus chinensis extract shown 93.1% at 1,000ppm concentration. And, in ABTS inhibition effect, 70% ethanol extracts from Rhus chinensis shown 88.8% at 1,000ppm concentration. But, in tyrosinase inhibition effect, 70% ethanol extracts from Rhus chinensis shown 21.7% at 1,000ppm concentration. In elastase inhibition effect, 70% ethanol extracts from Rhus chinensis shown 37.6% at 1,000 ppm concentration.
As a result of this study is data analysis for acute toxicity and safety of 70% ethanol extracts from Rhus chinensis. We investigated the acute toxicity for 70% ethanol extracts from Rhus chinensis. Forty male and female mice were observed for 14 days after one day oral administration of Rhus chinensis at the respective doses of 0 (control group), 500, 1,000, 2,000㎎/㎏. We observed survival rates, general toxicity, change of body weight and autopsy. In animals administered with Rhus chinensis, there were nither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign and autopsy. The data confirmed that Rhus chinensis is free from the toxicity and safety problems in treated groups. Compared with the control group, we could not find any toxic alteration in all treated groups (500, 1,000, 2,000 ㎎/㎏). Lethal Dose 50 (LD 50) value for mice was more than 2,000㎎/㎏ per oral for both male and females. It suggest that Rhus chinensis in mice is considered to be safe.
Therefore, it was confirmed that the 70% ethanol extracts from Rhus chinensis had significant effects on antioxidant activity and no toxicity in the toxicity test, confirming the possibility of functional cosmetic material.
A Study on the Efficacy and Toxicity of Rhus chinensis extract as a Cosmetic Material
Seung-Jin Jung
Department of Cosmetic Science, The Gradute School
Hoseo University
Asan, Korea
(Supervised by professor Jin-Young Lee)
The purpose of this study is to investigate whether Rhus chinensis extract can be used as a cosmetic raw material. The electron donating ability of 70% ethanol extract from Rhus chinensis extract shown 93.1% at 1,000ppm concentration. And, in ABTS inhibition effect, 70% ethanol extracts from Rhus chinensis shown 88.8% at 1,000ppm concentration. But, in tyrosinase inhibition effect, 70% ethanol extracts from Rhus chinensis shown 21.7% at 1,000ppm concentration. In elastase inhibition effect, 70% ethanol extracts from Rhus chinensis shown 37.6% at 1,000 ppm concentration.
As a result of this study is data analysis for acute toxicity and safety of 70% ethanol extracts from Rhus chinensis. We investigated the acute toxicity for 70% ethanol extracts from Rhus chinensis. Forty male and female mice were observed for 14 days after one day oral administration of Rhus chinensis at the respective doses of 0 (control group), 500, 1,000, 2,000㎎/㎏. We observed survival rates, general toxicity, change of body weight and autopsy. In animals administered with Rhus chinensis, there were nither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign and autopsy. The data confirmed that Rhus chinensis is free from the toxicity and safety problems in treated groups. Compared with the control group, we could not find any toxic alteration in all treated groups (500, 1,000, 2,000 ㎎/㎏). Lethal Dose 50 (LD 50) value for mice was more than 2,000㎎/㎏ per oral for both male and females. It suggest that Rhus chinensis in mice is considered to be safe.
Therefore, it was confirmed that the 70% ethanol extracts from Rhus chinensis had significant effects on antioxidant activity and no toxicity in the toxicity test, confirming the possibility of functional cosmetic material.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.