본 연구는 방부효과를 가지는 Xylityl caprylate/citrate를 합성하는 것으로 Xylitol과 Caprylic acid, Citric acid를 효소반응으로 에스테르화 합성하여 세균 및 진균에 대한 항균 활성 효과를 확인하였다. 기존의 산 촉매를 이용한 고온의 에스테르 합성조건에서는 ...
본 연구는 방부효과를 가지는 Xylityl caprylate/citrate를 합성하는 것으로 Xylitol과 Caprylic acid, Citric acid를 효소반응으로 에스테르화 합성하여 세균 및 진균에 대한 항균 활성 효과를 확인하였다. 기존의 산 촉매를 이용한 고온의 에스테르 합성조건에서는 작용기가 세 개인 Citric acid의 중합반응으로 생성물이 폴리머화 및 정제가 어려운 문제가 있었으나 본 연구에서는 용매 존재하에 효소 (Lipaseacrylic resin from Candida antarctica)를 이용해 저온(70℃)에서 합성 및 정제 과정을 거쳐 혼합물 형태의 Xylityl caprylate/citrate를 얻었고 기존의 고온 합성 방법으로 인한 문제점을 해결하였다. 생성물은 FT-IR(Fourier transfer infrared spectroscopy) 및 GPC (Gel permeation chromatography)로 확인하였다. 항균 활성을 측정하기 위해 S. aureus, P. aeruginosa, E. coli, C. albicans, 및 A. niger 균 5종에 대하여 Disc diffusion assay, MIC test를 진행하였고 Challenge test를 진행하여 화장품 적용시의 방부효과를 확인하였다. 결과 Xylityl caprylate/citrate 1%를 단독 적용하였을 때 그람 양성균 S. aureus 및 그람 음성균 P. aeruginosa, E. coli 에 대해 효과가 있음을 확인하였다. Caprylyl glycol과 혼합하여 곰팡이에 대한 항균 활성을 확보하였고 화장품용 방부제로서 적용 가능함을 확인하였다.
본 연구는 방부효과를 가지는 Xylityl caprylate/citrate를 합성하는 것으로 Xylitol과 Caprylic acid, Citric acid를 효소반응으로 에스테르화 합성하여 세균 및 진균에 대한 항균 활성 효과를 확인하였다. 기존의 산 촉매를 이용한 고온의 에스테르 합성조건에서는 작용기가 세 개인 Citric acid의 중합반응으로 생성물이 폴리머화 및 정제가 어려운 문제가 있었으나 본 연구에서는 용매 존재하에 효소 (Lipase acrylic resin from Candida antarctica)를 이용해 저온(70℃)에서 합성 및 정제 과정을 거쳐 혼합물 형태의 Xylityl caprylate/citrate를 얻었고 기존의 고온 합성 방법으로 인한 문제점을 해결하였다. 생성물은 FT-IR(Fourier transfer infrared spectroscopy) 및 GPC (Gel permeation chromatography)로 확인하였다. 항균 활성을 측정하기 위해 S. aureus, P. aeruginosa, E. coli, C. albicans, 및 A. niger 균 5종에 대하여 Disc diffusion assay, MIC test를 진행하였고 Challenge test를 진행하여 화장품 적용시의 방부효과를 확인하였다. 결과 Xylityl caprylate/citrate 1%를 단독 적용하였을 때 그람 양성균 S. aureus 및 그람 음성균 P. aeruginosa, E. coli 에 대해 효과가 있음을 확인하였다. Caprylyl glycol과 혼합하여 곰팡이에 대한 항균 활성을 확보하였고 화장품용 방부제로서 적용 가능함을 확인하였다.
The purpose of this study was to synthesize and screen Xylityl caprylate/citrate with anti-microbial activity against bacteria and fungi. Xylityl caprylate/citrate was synthesized by esterification reaction with lipase acrylic resin which its enzyme activity was derived from Candida Antarctica. The ...
The purpose of this study was to synthesize and screen Xylityl caprylate/citrate with anti-microbial activity against bacteria and fungi. Xylityl caprylate/citrate was synthesized by esterification reaction with lipase acrylic resin which its enzyme activity was derived from Candida Antarctica. The reactions proceeded with acid catalyst at high temperature. However, esterification reaction caused some byproducts as a result of self-polymerization in three functional groups of citric acid. In this study, the problem of self-polymerization was solved by changing into low temperature under the same condition. The chemical structure of product was determined by FT-IR (Fourier transform infrared spectroscopy) and GPC (Gel permeation chromatography). To measure the antimicrobial activity, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergillus niger were used in MIC test. It was showed that Xylityl caprylate/citrate has effect on S. aureus, P. aeruginosa and E. coli when applied by 1%. The preservation activity was confirmed by Challenge test. The antimicrobial activity against A. niger was apparent by mixing with Caprylyl glycol, and it was confirmed that Xylityl caprylate/citrate plus Caprylyl glycol could be applied as a cosmetic preservative.
The purpose of this study was to synthesize and screen Xylityl caprylate/citrate with anti-microbial activity against bacteria and fungi. Xylityl caprylate/citrate was synthesized by esterification reaction with lipase acrylic resin which its enzyme activity was derived from Candida Antarctica. The reactions proceeded with acid catalyst at high temperature. However, esterification reaction caused some byproducts as a result of self-polymerization in three functional groups of citric acid. In this study, the problem of self-polymerization was solved by changing into low temperature under the same condition. The chemical structure of product was determined by FT-IR (Fourier transform infrared spectroscopy) and GPC (Gel permeation chromatography). To measure the antimicrobial activity, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergillus niger were used in MIC test. It was showed that Xylityl caprylate/citrate has effect on S. aureus, P. aeruginosa and E. coli when applied by 1%. The preservation activity was confirmed by Challenge test. The antimicrobial activity against A. niger was apparent by mixing with Caprylyl glycol, and it was confirmed that Xylityl caprylate/citrate plus Caprylyl glycol could be applied as a cosmetic preservative.
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