Recently, with the development of information and communication technology
and medical technology, the health care system is changing from hospital-centered to
human-centered. As a result, many types of biosensors have been developed that can
monitor a patient's health condition. A patie...
Recently, with the development of information and communication technology
and medical technology, the health care system is changing from hospital-centered to
human-centered. As a result, many types of biosensors have been developed that can
monitor a patient's health condition. A patient's health condition can be roughly
determined by monitoring biophysical signals such as body temperature and heart rate.
However, the measurement of biomarkers in body fluids is necessary to obtain detailed
and much more information. Among body fluids, sweat can provide a significant
amount of information about a patient's health condition. Therefore, sweat is gaining
attention as a biological specimen. In this research, we have developed high
performance flexible biosensors that measure glucose and cortisol levels in sweat.
The concentration of glucose in the blood is very important for diabetics.
However, in order to measure glucose from the blood, the body must be cut to collect
blood or a sensor must be inserted into the body. Recently, it is reported that sweat
glucose and blood glucose have similar performance tendencies. Recently, much
research has been performed to measure glucose in sweat. However, there is still a
need for sensor development with ultra-low detection limit due to the concentration of
glucose in sweat is very low. In this research, we achieved an ultra-low detection limit
by depositing noble platinum nanoparticles (PtNPs) and fixing glucose oxidase (GOx)
onto laser-induced graphene (LIG) electrode. The laser-induced graphene (LIG) was
fabricated by burning polyimide (PI) films using CO2 laser. The fabricated flexible
glucose sensor exhibited an ultra-low detection limit of 0.52 μM.
Cortisol, called stress hormones, is secreted by the adrenal gland when
subjected to emotional stress. Cortisol causes increased blood pressure and blood
glucose. If cortisol is kept at a high concentration due to constant stress, it leads to
cardiovascular, immune, and endocrine problems, resulting in the development of
chronic diseases. Therefore, it is very important to measure the concentration of
cortisol in the human body. The concentration of sweat cortisol is very similar to that
of blood cortisol in human body. We built a microfluidic system that can automatically
collect sweat from the skin and a sensor that can measure cortisol from the collected
sweat. A substrate and microfluidic channels were fabricated using
polydimethylsiloxane (PDMS), a flexible agent for easy attachment to the skin. LIG
was transferred to PDMS to form the electrodes. And in sweat, the optimum level of
cortisol ranges from 0.02 to 0.5 mM. 2D Ti3C2 MXene, a multilayer accordion-like
structure, with excellent conductivity and large surface area was deposited to working
electrodes to achieve a lower detection limit. The flexible cortisol sensor was finally
fabricated by fixing cortisol antibody to working electrodes.
Recently, with the development of information and communication technology
and medical technology, the health care system is changing from hospital-centered to
human-centered. As a result, many types of biosensors have been developed that can
monitor a patient's health condition. A patient's health condition can be roughly
determined by monitoring biophysical signals such as body temperature and heart rate.
However, the measurement of biomarkers in body fluids is necessary to obtain detailed
and much more information. Among body fluids, sweat can provide a significant
amount of information about a patient's health condition. Therefore, sweat is gaining
attention as a biological specimen. In this research, we have developed high
performance flexible biosensors that measure glucose and cortisol levels in sweat.
The concentration of glucose in the blood is very important for diabetics.
However, in order to measure glucose from the blood, the body must be cut to collect
blood or a sensor must be inserted into the body. Recently, it is reported that sweat
glucose and blood glucose have similar performance tendencies. Recently, much
research has been performed to measure glucose in sweat. However, there is still a
need for sensor development with ultra-low detection limit due to the concentration of
glucose in sweat is very low. In this research, we achieved an ultra-low detection limit
by depositing noble platinum nanoparticles (PtNPs) and fixing glucose oxidase (GOx)
onto laser-induced graphene (LIG) electrode. The laser-induced graphene (LIG) was
fabricated by burning polyimide (PI) films using CO2 laser. The fabricated flexible
glucose sensor exhibited an ultra-low detection limit of 0.52 μM.
Cortisol, called stress hormones, is secreted by the adrenal gland when
subjected to emotional stress. Cortisol causes increased blood pressure and blood
glucose. If cortisol is kept at a high concentration due to constant stress, it leads to
cardiovascular, immune, and endocrine problems, resulting in the development of
chronic diseases. Therefore, it is very important to measure the concentration of
cortisol in the human body. The concentration of sweat cortisol is very similar to that
of blood cortisol in human body. We built a microfluidic system that can automatically
collect sweat from the skin and a sensor that can measure cortisol from the collected
sweat. A substrate and microfluidic channels were fabricated using
polydimethylsiloxane (PDMS), a flexible agent for easy attachment to the skin. LIG
was transferred to PDMS to form the electrodes. And in sweat, the optimum level of
cortisol ranges from 0.02 to 0.5 mM. 2D Ti3C2 MXene, a multilayer accordion-like
structure, with excellent conductivity and large surface area was deposited to working
electrodes to achieve a lower detection limit. The flexible cortisol sensor was finally
fabricated by fixing cortisol antibody to working electrodes.
주제어
#Laser-induced graphene (LIG) Flexible electrochemical biosensor Microfluidic Sweat glucose Cortisol Platinum nanoparticles (PtNPs) Ti3C2 MXene
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