Abstract ▼ AI-Helper

In this study, we fabricated Centella asiatica extract (CAE)-loaded hyaluronic acid–dextran (HA-Dex) hybrid hydrogel patch as an efficacious treatment for atopic dermatitis. Antiseptic ointments and creams containing steroids can be used to treat atopic dermatitis. However, they can also excessively...

In this study, we fabricated Centella asiatica extract (CAE)-loaded hyaluronic acid–dextran (HA-Dex) hybrid hydrogel patch as an efficacious treatment for atopic dermatitis. Antiseptic ointments and creams containing steroids can be used to treat atopic dermatitis. However, they can also excessively inhibit immune response and promote the propagation of pathogens, resulting in an increased risk of infection and atopic induction. If abused, steroid ointments can also inhibit collagen synthesis, leading to shrinkage and thinning of the collagen layer. An atopic patch that had been proposed to address this problem to minimize skin irritation, but it lacks adhesion and absorption to specific areas. Thus, we developed a high-absorbent hydrogel patch for the extended release of CAE (a natural polymer for atopic treatment) to localized areas. The CAE-embedded HA-Dex hybrid hydrogel patch was fabricated into a sheet-type scaffold by using a freeze-drying process and 1,4-butanediol diglycidyl ether (BDDE). Keratinocytes (HaCaT cells) and fibroblast(L929 cells) were used to evaluate cell survival; and Fourier transform infrared spectrometry, field emission scanning electron microscopy, mechanical testing, high-performance liquid chromatography, and porosity analysis were used to analyze physical properties. The results confirmed that scaffolding can be utilized to create CAE-embedded patches for use in preventative studies on atopic conditions. The hydrogel patches, which provide moisture and release CAE over an extended period of time, can relieve atopic itching; thus, in the future, the delivery system we developed in this study might be utilized to apply a variety of products for the treatment of atopic dermatitis.

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