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논문 상세정보

DHA가 풍부한 어유가 새끼쥐의 뇌발달과 학습능력에 미치는 영향

Effect of DHA-Rich Fish Oil on Brain Development and Learing Ability in Rats

Abstract

Effect of DHA-rich fish oil on brain development and learning ability has been studied in Sprague Dawley rats. Female rats were fed experimental diets containing either corn oil fish oil at 10%(w/w) level throughout the gestation and lactation. Corn oil was added in fish oil diet to supply essential fatty acid at 2.3% of the calories. All male pups were weaned to the same diets of dams at 21-days after birth. Plasma fatty acid composition was analyzed for dams and pups at 21-days, 28-days and 22-weeks after birth. The analysis of DNA and fatty acid profile in the brain were undertaken at birth, 3, 7, 14, 21, 28 days and 22 weeks after birth and learning ability was tested at 18-20 weeks of age. Regardless of dietary fats, arachidonic acid(AA) and docosahexaenoic acid(DHA) were the principal polyunsaturated fatty acids in the brain. Rats fed CO diet showed a continouus increase of AA content in the brain from 10.9%(at birth) to maximum 15.3% level (14-days old), while the rars fed FO diet showed 78-79% of CO group throughout the period. Rats fed FO diet showed higher incorparation of DHA from 15.2% at birth to a maximum level of 18.5% at 140days, while the rats fed CO diet showed only 7.0% incorporation of DHA at birth and a maximum level of 11.1% at 21-days. Compared to CO group, FO group showed lower ratio of chol/PL and higher content of DHA in brain microsomal membrane, resulting in better membrane fluidity. Total amount of DNA per gram of brain was reached maximum level at 21 days in both groups. This would be a period of the cell proliferation during brain development. Overall, the rats fed fish oil diet showed a higher incorporation of DHA and membrane fluidity in the brain and better learning performances (p<0.05).

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참고문헌 (32)

  1. Essential fatty acid requirements in pregnancy and lactation with special reference to brain development , Crawford,M.A.;Hassam,A.G.;Stevens,D.A. , Prog Lipid Res / v.20,pp.31-40, 1981
  2. ω-3 fatty acids in heath and disease and in growth and development , Simopoulus,A.P. , Nutr Today / v.,pp.10-19, 1989
  3. ω-3 fatty acids in heath and disease and in growth and development , Simopoulus,A.P. , Am J Clin Nutr / v.54,pp.438-463, 1991
  4. Effect of low intake of n-3 fatty acids during development on brain phospholipid fatty acid composition and exploratory behavior in rats , Enslen,M.;Milon,H.;Malnoe,A. , Lipids / v.26,pp.203-208, 1991
  5. Essential fatty acids : The importance of n-3 fatty acids in the retina and brain , Conner,W.E.;Neuringer,M.;Reisbick,S. , Nutr Rev / v.50,pp.21-29, 1992
  6. The role of essential fatty acids in neural development : implication for perinatal nutrition , Crawford,M.A. , Am J Clin Nutr / v.57,pp.703S-710S, 1993
  7. The essentiality of n-3 fatty acids for the development and function of the retina and brain , Neuringer,M.;Anderson,G.J.;Connor,W.E. , Ann Rev Nutr / v.8,pp.517-541, 1988
  8. Simopoulos,A.P.;Kifer,R.R.;Martin,R.E. , Health effects of polyunsaturated fatty acids in seafoods / v.,pp., 1986
  9. N-3 fatty acids in the brain and retina : evidence for their essentiality , Neuringer,M.;Connor,W.E. , Nutr Rev / v.44,pp.285-294, 1986
  10. Biochemical and functional effects of prenatal and postnatal ω3 fatty acid deficiency on retina and brain in rhesus monkeys , Neuringer,M.;Connor,W.E.;Lin,D.S.;Barstad,L.;Luck,S. , Proc Natl Acad Sci USA / v.83,pp.4021-4025, 1986
  11. Hurley,L.S. , Developmental nutrition / v.,pp., 1980
  12. The lipid composition of rat brain myelin and subcellular fractions during development , Cuzner,M.L.;Davison,A.N. , Biochem J / v.106,pp.29-34, 1968
  13. The accumulation of arachidonate and docosahexaenoate the developing brain , Sinclair,A.J.;Crawford,M.A. , J Neurochem / v.19,pp.1753-1758, 1972
  14. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver , Scott,B.L.;Bazan,N.G. , Neurobiology / v.86,pp.2903-2907, 1989
  15. The effects of dietary α-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats , Bourre,J.M.;Francois,M.;Youyou,A.;Dumont,O.;Piciotti,M.;Pascal,G.;Durand,G. , J Nutr / v.119,pp.1880-1892, 1989
  16. The role of n-3 essential fatty acid in brain and behavioral development : A cross-fostering study in the mouse , Wainwright,P.E.;Huang,Y.S.;Bulman Fleming B;Mills,D.E.;Redden,P.;Cutcheon,D. , Lipids / v.26,pp.37-45, 1991
  17. Dietary n-3 fatty acid deficiency and visual loss in infant rhesus monkey , Neuringer,M.;Connor,W.E.;Barstad,L. , J Clin Invest / v.73,pp.272-276, 1984
  18. Maternal dietary fish oil enriches docosahexaenoate levels in brain subcellular fractions of offspring , Yeh,Y.Y.;Gehman,M.F.;Yeh,S.M. , J Neuro Res / v.35,pp.218-226, 1993
  19. A rapid method of total lipid extraction and purification , Bligh,E.G.;Dyer,W.J. , Can J Biochem Physiol / v.37,pp.911-917, 1959
  20. Preparation of fatty acid methylesters and dimethylacetals from lipids with boron fluoridemethanol , Morrison,W.R.;Smith,L.M. , J Lipid Res / v.5,pp.600-608, 1964
  21. A fluorometric method for total serum cholesterol , McDougal,D.B.;Farmer,H.S. , J Lab and Clin Med / v.50,pp.485-488, 1987
  22. Phosphorous assay in column chromatography , Bartlett,G.R. , J Biol Chem / v.234,pp.466-468, 1959
  23. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid , Burton , Biochem J / v.62,pp.315-322, 1956
  24. Bonnie,S.;Worthington,G. , Nutrition in preganacy and lactation / v.,pp., 1985
  25. 유두체가 제거된 흰쥐의 일반활동, 정서활동, 미로학습 , 장현갑;윤병두 , 한국심리학회 연차대회 / v.,pp., 1987
  26. Enrichment of (n-3) fatty acids of suckling rats by maternal dietary menhaden oil , Yeh,Y.Y.;Winters,B.L.;Yeh,S.M. , J Nutr / v.120,pp.436-443, 1990
  27. Human milk and formula fatty acids , Innis,S.M. , J Pediatr / v.120,pp.S57-S61, 1992
  28. Tissue levels of polyunsaturated fatty acids during early human development , Maritinez,M. , J Pediatr / v.120,pp.S129-S138, 1992
  29. Monoenoic fatty acids in human brain lipids : isomer identification and distribution , Johnson,D.W.;Beckman,K.;Fellenberg,A.J.;Robinson,B.S.;Poulos,A. , Lipids / v.27,pp.177-180, 1992
  30. Uptake of 22-carbon fatty acids into rat retina and brain , Wang,N.;Wiegand,R.D.;Anderson,R.E. , Exp Eye Res / v.54,pp.933-939, 1992
  31. Maternal dietary fat and polyunsaturated fatty acids in the developing fetal rat brain , Samulski,M.A.;Walker,B.L. , J Neurochem / v.39,pp.1163-1168, 1982
  32. Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in mylin, synaptosomes, mitochondria, and microsomes of developing rat brain , Youyou,A.;Durand,G.;Pascal,G.;Piciotti,M.;Dumont,O.;Bourre,J.M. , J Neurochem / v.46,pp.224-228, 1986

이 논문을 인용한 문헌 (2)

  1. 1998. "Influence of Dietary Supplementation of Fish Oil at Different Life Cycle on the Incorporation of DHA into Brain in Rats" 韓國營養學會誌 = The Korean journal of nutrition., 31(7): 1100~1111 
  2. 1999. "Effect of Dietary Supplementation of DHA and AA on the Incorporation of Long Chain Fatty Acid and DNA Content in the Developing Brain of Rats" 韓國營養學會誌 = The Korean journal of nutrition., 32(5): 526~532 

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