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Abstract ▼ AI-Helper

The antioxidant activity of Symphyocladia latiuscula was determined by measuring lipid peroxide produced when a mouse liver homogenate was exposed to the air at $37^{\circ}C$, using 2-thiobarbituric acid (TBA) and radical scavenging effect on 1,1 - diphenyl - 2 - picrylhydrazyl (DPPH) rad...

The antioxidant activity of Symphyocladia latiuscula was determined by measuring lipid peroxide produced when a mouse liver homogenate was exposed to the air at $37^{\circ}C$, using 2-thiobarbituric acid (TBA) and radical scavenging effect on 1,1 - diphenyl - 2 - picrylhydrazyl (DPPH) radical, and free radical generation inhibition by $ACF_2$(Hepatocyte). The methanol extract of S. latiuscula showed high antioxidant activity. And the methanol extract was fractionated with several solvents. With regard their fractions, the antioxidant activity were in the order of dichloromethane > hexane > butanol > ethyl acetate > water fraction. The dichloromethane fraction showed the strongest radical scavenging activity ($50\%$ inhibitory concentration[$IC_{50}$]=3,14 $\mu$g/ml), and strong inhibitory effect on the lipid peroxidation of the mouse liver homogenate, which was compared with lascorbic acid, inhibition effect was stronger than Lascorbic acid. The methanol extract of S. latiuscula and its dichlromethane soluble fraction also inhibited over $50\%$ at concentration of 0.2 mg/ml and 0.1 mg/ml on free radical generation of hepatocyte ($AC_2F$). While the water fraction was inactive in all the assay for antioxidant activity.

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