Sa-Mul-Tang (Si-Wu-Tang, SMT), a kind of Chinese medicine, has been used for the hemato-deficient disease for hundreds of years. In this work, investigations on the anti-anemic activity of an aqueous extract of SMT were undertaken in order to find the pharmacological basis for the ethnomedical use o...
Sa-Mul-Tang (Si-Wu-Tang, SMT), a kind of Chinese medicine, has been used for the hemato-deficient disease for hundreds of years. In this work, investigations on the anti-anemic activity of an aqueous extract of SMT were undertaken in order to find the pharmacological basis for the ethnomedical use of the formulation. Three kinds of Angelicase species, such as Angelica sinensis, Angelica acutiloba, and Angelica gigas, were used for preparing the water extracts of SMT. Anemic model rats were induced by the treatment of phenylhydrazine (40 mg/kg/day, i.p.) for 4 days. After the treatment of phenylhydrazine, rats were divided into several groups for their different treatment of three kinds of SMT. Red blood cell (RBC), hemoglobin (Hg), and hematocrit (Hct) were determined on the day 0, 3, 6, 10, 14 after the treatment of SMTs and erythrocytes deformabilities were also determined at the end of experiments. Oral administration of SMT (1g/kg/day) for 14 days did not ameliorate drug-induced anemic states evaluated by RBC counts, Hg contents, and Hct values. However, the erythrocyte deformabilities were improved in phenylhydrazine-treated group by the administragest that SMTs (p<0.05). Especially, these effects were high in the Angelica acutiloba group. These results suggest that SMTs have an ameliorative effect on blood rheology related to the blood stasis syndrome in oriental diagnostics not on the blood deficient states related to the anemic syndrome.
Sa-Mul-Tang (Si-Wu-Tang, SMT), a kind of Chinese medicine, has been used for the hemato-deficient disease for hundreds of years. In this work, investigations on the anti-anemic activity of an aqueous extract of SMT were undertaken in order to find the pharmacological basis for the ethnomedical use of the formulation. Three kinds of Angelicase species, such as Angelica sinensis, Angelica acutiloba, and Angelica gigas, were used for preparing the water extracts of SMT. Anemic model rats were induced by the treatment of phenylhydrazine (40 mg/kg/day, i.p.) for 4 days. After the treatment of phenylhydrazine, rats were divided into several groups for their different treatment of three kinds of SMT. Red blood cell (RBC), hemoglobin (Hg), and hematocrit (Hct) were determined on the day 0, 3, 6, 10, 14 after the treatment of SMTs and erythrocytes deformabilities were also determined at the end of experiments. Oral administration of SMT (1g/kg/day) for 14 days did not ameliorate drug-induced anemic states evaluated by RBC counts, Hg contents, and Hct values. However, the erythrocyte deformabilities were improved in phenylhydrazine-treated group by the administragest that SMTs (p<0.05). Especially, these effects were high in the Angelica acutiloba group. These results suggest that SMTs have an ameliorative effect on blood rheology related to the blood stasis syndrome in oriental diagnostics not on the blood deficient states related to the anemic syndrome.
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제안 방법
After PHZ injection, the rats were randomly assigned to control or treat ment groups. Animals were selected for further studies into four groups, SMT-S treated group, SMT-A heated group, SMT-G treated group, and normal saline treated group as pos itive control. Animals received 14 daily injections of either SMT-S, SMT-A or SMT-G by 1 g/kg (p.
데이터처리
The data were analyzed with one-way analysis of variance (ANOVA) followed by the Student-Newman-Keuls method for multiple comparison. P<0, 05 was considered to be signifi cantly in all cases.
성능/효과
Unlike as the fragil ity test, SMT-S and SMT-G had about the same effects on the filterability. From the fragility and deformability tests, our results suggest that SMT has an ameliorative effect on blood rheology related to PHZ-induced blood stasis and SMT con taining the Angelica sinensis (SMT-S) Angelica acutiloba (SMT-A) are more useful for these syndi-ome than Angelica gigas (SMT-G). However, the reasons why the deformability and fragility of erythrocyte were changed by the vaiying with the Angelica species are not known but may be because of their constituents.
PHZ are well recognized as a hemolytic anemic inducer (Cynshi et aL, 1990). There were no significant changes in the RBC counts, Hg contents and Het values by the treatment of SMTs, such as SMT-A, SMT-S, and SMT-G compared with those of PHZ- treated rats during the experiments (Table I). There were also no changes in the various parameters, such as MCV, MCH, and MCHC (data not shown) However, there are several reports that SMT plays a role in the anemic states (Kim, 1998.
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