개에서 Isoflurane 마취시 SP-6 혈위의 전침자극시간이 최소폐포농도 및 심맥관계에 미치는 영향 Effect of Electroacupuncture at SP-6 with Different Durations on Minimum Alveolar Concentration and the Cardiovascular System under Isoflurane Anesthesia in Dogs원문보기
본 연구에서는 개에서 전침술이 isoflurane 마취시의 MAC 및 심맥관계에 미치는 영향 및 전침처치시간에 따른 차이에 대하여 조사하였다. 임상적으로 건강한 19개월령, 수컷 비글견 8두를 사용하였다. 대조군, 비혈위 전기자극군, 30분간 전침군(SP-6) 및 연속 전침군(SP-6C)으로 나누어 군 당 5두씩 무작위로 최소 7일간의 휴약기를 두며 실험에 사용하였다. 전침처치는 SP-6 혈위에 2-4V 20Hz로 30분간(SP-6)또는 MAC의 측정이 끝날 때 까지 연속적으로(SP-6C) 실시하였다. SP-6C군에서의 전침자극시간은 70-90분이었다. Isoflurane으로 마취를 유도한 후 전침을 실시하고 MAC와 cardiovascular parameters를 측정 하였다. 전침 후 MAC는 SP-6 및 SP-6C 군에서 각각 21.3$\pm$8.0% 및 16.1$\pm$4.6% 씩 유의적으로 저하되었으나(p<0.05) 전침시간에 따른 유의성은 없었다. 그러나 대조군과 비혈위 전기자극군에 비해서는 유의적으로 저하되었다(p<0.05). 전침처치 후 심맥관계에는 유의성 있는 변화가 인정되지 않았다. 이상의 결과로 보아, SP-6혈위에 대한 전침은 개에서 심맥관계의 부작용을 최소화하면서isoflurane의 MAC을 유의성 있게 감소시켰으며, 이러한 효과는 30분간의 전침자극으로 충분하다고 사료된다.
본 연구에서는 개에서 전침술이 isoflurane 마취시의 MAC 및 심맥관계에 미치는 영향 및 전침처치시간에 따른 차이에 대하여 조사하였다. 임상적으로 건강한 19개월령, 수컷 비글견 8두를 사용하였다. 대조군, 비혈위 전기자극군, 30분간 전침군(SP-6) 및 연속 전침군(SP-6C)으로 나누어 군 당 5두씩 무작위로 최소 7일간의 휴약기를 두며 실험에 사용하였다. 전침처치는 SP-6 혈위에 2-4V 20Hz로 30분간(SP-6)또는 MAC의 측정이 끝날 때 까지 연속적으로(SP-6C) 실시하였다. SP-6C군에서의 전침자극시간은 70-90분이었다. Isoflurane으로 마취를 유도한 후 전침을 실시하고 MAC와 cardiovascular parameters를 측정 하였다. 전침 후 MAC는 SP-6 및 SP-6C 군에서 각각 21.3$\pm$8.0% 및 16.1$\pm$4.6% 씩 유의적으로 저하되었으나(p<0.05) 전침시간에 따른 유의성은 없었다. 그러나 대조군과 비혈위 전기자극군에 비해서는 유의적으로 저하되었다(p<0.05). 전침처치 후 심맥관계에는 유의성 있는 변화가 인정되지 않았다. 이상의 결과로 보아, SP-6혈위에 대한 전침은 개에서 심맥관계의 부작용을 최소화하면서isoflurane의 MAC을 유의성 있게 감소시켰으며, 이러한 효과는 30분간의 전침자극으로 충분하다고 사료된다.
The effects of electroacupuncture (EA) at SP-6 with different durations on the minimum alveolar concentration (MAC) and on the cardiovascular system were evaluated in dogs under isoflurane anesthesia. Eight healthy male beagles were randomly assigned to four study groups (n = 5/group) with washout p...
The effects of electroacupuncture (EA) at SP-6 with different durations on the minimum alveolar concentration (MAC) and on the cardiovascular system were evaluated in dogs under isoflurane anesthesia. Eight healthy male beagles were randomly assigned to four study groups (n = 5/group) with washout period of 7 days for recovery and anesthetic withdrawal between experiments. Four study groups were control, nonacupoint electrical stimulation (NA), EA for 30 minutes (SP-6) and continuous EA for 70 or 90 minutes (SP-6C). For the nonacupoint electrical stimulation group, needles were inserted into the nonacupoint at the muscle bellies of left triceps brachii and right quadriceps femoris. MAC and cardiovascular parameters were determined after EA at SP-6 acupoint and at nonacupoint. Thirty minutes of EA and continuous EA until re-determination of MAC at SP-6 acupoint lowered the MAC of isoflurane by 21.3$\pm$8.0% and 16.1$\pm$4.6%, respectively (p<0.05). The decrements in MAC values were not significantly different between two EA groups. However, electrical stimulation of nonacupoint did not induce a significant change in MAC. In SP-6 and SP-6C groups, significant changes in cardiovascular parameters were not observed. These results indicate that EA at SP-6 have an advantage in isoflurane anesthesia in terms of reducing the requirement for anesthetics and minimizing cardiovascular side effects. EA for 30 minutes at maximum might be the sufficient time to produce acupuncture analgesia.
The effects of electroacupuncture (EA) at SP-6 with different durations on the minimum alveolar concentration (MAC) and on the cardiovascular system were evaluated in dogs under isoflurane anesthesia. Eight healthy male beagles were randomly assigned to four study groups (n = 5/group) with washout period of 7 days for recovery and anesthetic withdrawal between experiments. Four study groups were control, nonacupoint electrical stimulation (NA), EA for 30 minutes (SP-6) and continuous EA for 70 or 90 minutes (SP-6C). For the nonacupoint electrical stimulation group, needles were inserted into the nonacupoint at the muscle bellies of left triceps brachii and right quadriceps femoris. MAC and cardiovascular parameters were determined after EA at SP-6 acupoint and at nonacupoint. Thirty minutes of EA and continuous EA until re-determination of MAC at SP-6 acupoint lowered the MAC of isoflurane by 21.3$\pm$8.0% and 16.1$\pm$4.6%, respectively (p<0.05). The decrements in MAC values were not significantly different between two EA groups. However, electrical stimulation of nonacupoint did not induce a significant change in MAC. In SP-6 and SP-6C groups, significant changes in cardiovascular parameters were not observed. These results indicate that EA at SP-6 have an advantage in isoflurane anesthesia in terms of reducing the requirement for anesthetics and minimizing cardiovascular side effects. EA for 30 minutes at maximum might be the sufficient time to produce acupuncture analgesia.
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문제 정의
The effect of EA on reducing the MAC of isoflurane in dogs has not been previously exam ined. This study was performed to compare the effects of EA with different durations at SP-6 on MAC and on the car diovascular system under isoflurane anesthesia in dogs.
제안 방법
The experimental groups were the control, nonacupoint electrical stimulation (NA) and two EA groups at SP-6 acu point with different duration of stimulation: fbr 30 minutes (SP-6), and continuous stimulation fbr 70 or 90 minutes until re-determination of MAC (SP-6C).
대상 데이터
Eight healthy male beagles (19 month-old, Jungang Lab Animal Co Seoul, Korea) were used for the study. Their mean body weight was 8.
데이터처리
Because ofthe non-Gaussian distribution ofthe cardiovascular variables, Friedmans test, which is a nonparametric ANOVA fbr repeated measures, was used to compare variables (Bl.5, Ml, M2, Al.5 and AM) within groups. When a difference was found to be significant between variables (p v 0.
05), multiple comparisons were done using the Wilcoxons signed rank test. Differences in cardiovascular variables among groups were analyzed using the Kruskal-Wallis test, and when a difference was significant (p < 0.05) between groups, the Mann-Whitney U test was used for the multiple comparisons (= 0.05).
To compare the baseline MAC and the post-EA MAC of each group, Wilcoxons signed rank test was used. For comparison of MAC decrements among groups the KruskalWallis test was used.
5 and AM) within groups. When a difference was found to be significant between variables (p v 0.05), multiple comparisons were done using the Wilcoxons signed rank test. Differences in cardiovascular variables among groups were analyzed using the Kruskal-Wallis test, and when a difference was significant (p < 0.
이론/모형
To compare the baseline MAC and the post-EA MAC of each group, Wilcoxons signed rank test was used. For comparison of MAC decrements among groups the KruskalWallis test was used. When a difference was found significant (p < 0.
5% after catheterization and this was maintained fbr 30 minutes at least. Noxious stimulation to determine MAC was performed using a tail-clamping technique with a hemo static forceps. The tail was clamped with hemostatic forceps until the ratchet caught, and was then shaken continuously fbr one minute or until a purposefi.
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