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논문 상세정보

마이크로에멀젼을 이용한 프로포폴 주사제의 개발 및 평가

Preparation and Evaluation of Propofol Microemulsion for Parenteral Use

약학회지 = Yakhak hoeji v.46 no.5 , 2002년, pp.337 - 342  
Abstract

Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous sedative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, $Solutol^{(R)}$ HS 15 and $Kollidon^{(R)}$ 17 PF. Propofol microemulsions were studied by transmittance, viscosity, particle size, in vitro release and pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 92.6~95.1 and 91.3~94.2%, respectively. Transmittance 1~2% decreased as concentration of $Kollidon^{(R)}$ 17 PF was increased and increased 0.8~3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9~4.1 mPaㆍsec and 4.4~5.3 mPaㆍsec, respectively. The particle sizes of A and B group increased as amount of $Kollidon^{(R)}$ 17 PF. Also, release of propofol was slowly increased as the amount of $Kollidon^{(R)}$ 17 PF was increased. Propofol plasma concentration by i.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emuision(POFOL).

참고문헌 (10)

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  8. Vree, T. B., Lagerwerf, A. J. and Bleeker, C. P. : Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man, J. Chromatogr. B 721, 217 (1999) 
  9. Yegareh, M. H. and Ramzan, L. : Determination of propofol in rat whole blood and plasma by high performance liquid chromatography, J Chromatogr. B 691, 478 (1997) 
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이 논문을 인용한 문헌 (1)

  1. Jeon Il-Soon ; Kim Jeong-Soo ; Lee Gye-Won ; Jee Ung-Kil 2005. "Preparation and Evaluation of Paclitaxel Nano-particle Delivery System for Parenteral Formulations" 약학회지 = Yakhak hoeji, 49(4): 268~274 

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