• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

마이크로에멀젼을 이용한 프로포폴 주사제의 개발 및 평가

Preparation and Evaluation of Propofol Microemulsion for Parenteral Use

약학회지 = Yakhak hoeji v.46 no.5 , 2002년, pp.337 - 342  

Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous sedative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, $Solutol^{(R)}$ HS 15 and $Kollidon^{(R)}$ 17 PF. Propofol microemulsions were studied by transmittance, viscosity, particle size, in vitro release and pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 92.6~95.1 and 91.3~94.2%, respectively. Transmittance 1~2% decreased as concentration of $Kollidon^{(R)}$ 17 PF was increased and increased 0.8~3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9~4.1 mPaㆍsec and 4.4~5.3 mPaㆍsec, respectively. The particle sizes of A and B group increased as amount of $Kollidon^{(R)}$ 17 PF. Also, release of propofol was slowly increased as the amount of $Kollidon^{(R)}$ 17 PF was increased. Propofol plasma concentration by i.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emuision(POFOL).

참고문헌 (10)

  1. Sarciaux, J. M., Acar, L. and Sado, P. A. : Invited Review : Using microemulsion formulations for oral drug delivery of therapeutic peptides, Int. J. Pharm. 120(2), 127 (1995) 
  2. Muhannad, J.and Bernd, W. : The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant, Int. J. Pharm. 174, 29 (1998) 
  3. Mark, S. L. and Rennie, C. H. : Propofol : A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anesthetic, Drugs 35, 334 (1988) 
  4. Kanto, J. and Gepts, E. : Pharmacokinetic implications for the clinical use of propofol, Clin. Pharmacokinet. 17(5), 308 (1989) 
  5. Ghiani, C. A., Tuligi, G., Maciocco, E., Serra, M., Sanna, E. and Biggio, G. : Biochemical evaluations of the effects of loreclezole and propofol on the GABA(A) receptor in rat brain, Biochem. Pharmacol. 51(11), 1527 (1996) 
  6. Laia, CAT., Brown, W., Almgren, M. and Costa, SMB. : Light scattering study of water-in-oil AOT microemulsions with poly(oxy)ethylene, Langmuir 16(2), 465 (2000) 
  7. Lehner, D., Lindner, H. and Glatter, O. : Determination of the translational and rotational diffusion coefficients of rodlike particles using depolarized dynamic light scattering, Langmuir 16(4), 1689 (2000) 
  8. Vree, T. B., Lagerwerf, A. J. and Bleeker, C. P. : Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man, J. Chromatogr. B 721, 217 (1999) 
  9. Yegareh, M. H. and Ramzan, L. : Determination of propofol in rat whole blood and plasma by high performance liquid chromatography, J Chromatogr. B 691, 478 (1997) 
  10. Sandeep, D. and Ebling, W. F. : Formulation-dependent Pharmacokinetics and Pharmacodynamics of Propofol in Rat, J. Pharm. Pharmacol. 50, 37 (1998) 

이 논문을 인용한 문헌 (1)

  1. Jeon Il-Soon ; Kim Jeong-Soo ; Lee Gye-Won ; Jee Ung-Kil 2005. "Preparation and Evaluation of Paclitaxel Nano-particle Delivery System for Parenteral Formulations" 약학회지 = Yakhak hoeji, 49(4): 268~274 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일