[논문]Inhibitory Effects of Glycine on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity in Mice

Shin, Kyung-Wook; Hong, Jin-Tae; Yoo, Hwan-Soo; Song, Sukgil; Oh, Ki-Wan

doi:10.1007/bf02994761

[국내논문] Inhibitory Effects of Glycine on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity in Mice 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.26 no.12, 2003년, pp.1074 - 1078

Shin, Kyung-Wook (Department of Manufacturing Pharmacy, College of Pharmacy, Chungbuk National University) , Hong, Jin-Tae (Department of Pharmacy, College of Pharmacy, Chungbuk National University) , Yoo, Hwan-Soo (Department of Pharmacy, College of Pharmacy, Chungbuk National University) , Song, Sukgil (Department of Manufacturing Pharmacy, College of Pharmacy, Chungbuk National University) , Oh, Ki-Wan (Department of Pharmacy, College of Pharmacy, Chungbuk National University)

Abstract ▼ AI-Helper

The effects of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice was examined. A single administration of morphine (10 mg/kg, s.c.) induced hyperactivity as measured in mice. The morphine-induced hyperactivity was inhibited by pretreatment with glycine (100, 200 and 400 mg/kg, i.p.). In addition, it was found repeated administration of morphine (10 mg/kg, s.c.) to mice daily for 6 days caused an increase in motor activity which could be induced by a subsequent morphine dose, an effect known as reverse tolerance or sensitization. Glycine (100, 200 and 400 rng/kg, i.p.) also inhibited morphine-induced reverse tolerance. Mice that had received 7 daily repeated administrations of morphine also developed postsynaptic dopamine receptor supersensitivity, as shown by enhanced ambulatory activity after administration of apomorphine (2 mg/kg, s.c.). Glycine inhibited the development of postsynaptic dopamine receptor supersensitivity induced by repeated administration of morphine. It is suggested that the inhibitory effects of glycine might be mediated by dopaminergic (DAergic) transmission. Accordingly, the inhibition by glycine of the morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity suggests that glycine might be useful for the treatment of morphine addiction.

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문제 정의

Therefore, this study was investigated to research whether glycine inhibits morphine-induced hyperactivity, reverse tolerance and enhanced sensitivity at the postsynaptic DA receptors.

제안 방법

Glycine (G, 100, 200, 400 ㎎/㎏, i.p.) was administered once a day 30 min before the injection of morphine (MOR, 10 ㎎/㎏), for 6 days. To test the degree of the development of reverse tolerance of morphine, mice were injected with morphine only, on day 7.
Glycine (G, 100, 200, 400 ㎎/㎏, i.p.) was administered once a day 30 min before the injection of morphine (MOR, 10 ㎎/㎏), for 6 days. To test the degree of the development of reverse tolerance of morphine, mice were injected with morphine only, on day 7.

대상 데이터

ICR m게e mice weighing 22-27 g, in groups of 10-15 mice were used in all experiments. They were ho너sed, 10 mice to a cage, with water and food available ad libitum 니nde「an artificial 12 h light/dark cycle (light on at 07:00) with a constant environmental temperature (22± 2℃).

데이터처리

The data were expressed as mean± SEM. The significance of the drug effects was assessed by an analysis of variance (ANOVA). In the case of significant variation, the individual val나es were compared by Dunnetts f-test.

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