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[국내논문] Differential Regulation of Cytochrome P450 Isozyme mRNAs and Proteins by Femur Fracture Trauma 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.26 no.12, 2003년, pp.1079 - 1086  

Lee, Woo-Young (College of Pharmacy, Sungkyunkwan University) ,  Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University)

Abstract AI-Helper 아이콘AI-Helper

The aim of this study was to investigate the effect of trauma on cytochrome P450 (CYP) gene expression and to determine the role of Kupffer cells in trauma-induced alteration of CYP isozymes. Rats underwent closed femur fracture (FFx) with associated soft-tissue injury under anesthesia. To deplete K...

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참고문헌 (37)

  1. Alam, J., Shibahara, S., and Smith, A., Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells. J. Biol. Chem., 264, 6371-6375 (1989) 

  2. Bauer, M., Pannen, B. H. J., Bauer, I., Herzog, C., Wanner, G. A., Hanselmann, R., Zhang, J. X., Clemens, M. G., and Larsen, R., Evidence for a functional link between stress response and vascular control in hepatic portal circulation. Am. J. Physiol., 271, G929-G935 (1996) 

  3. Bone, R. C., Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann. Intern. Med., 125, 680-687 (1996) 

  4. Bradham, C. A., Stachlewitsz, R. F., Gao, W., Qian, T., Jayadev, S., Jenkins, G., Hannun, Y., Lemasters, J. J., Thurman, R. G., and Brenner, D. A., Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology, 25, 1128-1135 (1997) 

  5. Brown, A. P., Harkema, J. R., Schultze, A. E., Roth, R. A., and Ganey, P. E., Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration. Shock, 7, 186-192 (1997) 

  6. Brun-Buisson, C., The epidemiology of the systemic inflammatory response. Intensive Care Med., 26, S64-S74 (2000) 

  7. Caldwell-Kenkel, J. C., Currin, R. T., Tanaka, Y., Thurman, R. G., and Lemasters, J. J., Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology, 13, 83-95 (1991) 

  8. Calleja, C., Eeckhoutte, C., Larrieu, G., Dupuy, J., Pineau, T., and Galtier, P., Differential effects of interleukin-1 beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes. Biochem. Biophys. Res. Commun., 239, 273-278 (1997) 

  9. Choi, A. M. K. and Alam, J., Heme oxygenase-1: Function, regulation and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol., 15, 9-19 (1996) 

  10. Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987) 

  11. Cutrin, J. C., Llesuy, S., and Boveris A., Primary role of Kupffer cell-hepatocyte communication in the expression of oxidative stress in the post-ischemic liver. Cell Biochem. Funct., 16, 65-72 (1998) 

  12. Denison, M. and Whitlock, J., Xenobiotic-inducible transcription of cytochrome P450 genes. J. Biol. Chem., 270, 18175-18178 (1995) 

  13. Eum, H. -A., Lee, S. -H., and Lee, S. -M., Trolox C ameliorates hepatic drug metabolizing dysfunction after ischemia/reperfusion. Arch. Pharm. Res., 25, 940-945 (2002) 

  14. Hong, J. Y., Pan, J. M., Gonzalez, F. J., Gelboin, H. V., and Yang, C. S., The induction of a specific form of P-450 (P-450i) by fasting. Biochem. Biophys. Res. Commun., 142, 1077-1083 (1987) 

  15. Huynh, T., Baker, C. C., Bracey, L. W., and Lemasters, J. J., Adaptive Kupffer cell alterations after femur fracture trauma in rats. Am. J. Physiol., 272, G1457-G1462 (1997) 

  16. Iber, H., Sewer, M. B., Barclay, T. B., Mitchell, S. R., Li, T., and Morgan, E. T., Modulation of drug metabolism in infectious and inflammatory diseases. Drug Metab. Rev., 31, 29-41 (1999) 

  17. Kemper, B., Mammalian cytochrome P-450 genes, Front. Biotransform., 8, 1-58 (1993) 

  18. Koo, D. J., Chaudry, I. H., and Wang, P., Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J. Surg. Res., 83, 151-157 (1999) 

  19. Kraemer, M. J., Furukawa, C., Koup, J., Shapiro, G., Pierson, W., and Bierman, W., Altered theophylline clearance during an influenza B outbreak. Pediatrics, 69, 476-480 (1982) 

  20. Kumamoto, Y., Suematsu, M., Shimazu, M., Kato, Y., Sano, T., Makino, N., Hirano, K. I., Naito, M., Wakabayashi, G., Ishimura, Y., and Kitajima, M., Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in postcold-ischemic rat liver. Hepatology, 30, 1454-1463 (1999) 

  21. Kutty, R. K., Daniel, R. F., Ryan, D. E., Levin, W., and Maines, M. D., Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase. Arch. Biochem. Biophys., 260, 638-644 (1988) 

  22. Lee, W. -Y. and Lee, S. -M., The roles of Kupffer cells in hepatocellular dysfunction after femur fracture trauma. Arch. Pharm. Res., 26, 47-52 (2003) 

  23. Monshouwer, M., McLellan, R. A., Delaporte, E., Witkamp, R. F., van Miert A. S., and Renton, K. W., Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem. Pharmacol., 52, 1195-1200 (1996) 

  24. Nakae, H. and Inaba, H., Expression of heme oxygenase-1 in the lung and liver tissues in a rat model of burns. Burns, 28, 305-309 (2002) 

  25. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W., P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42 (1996) 

  26. Nielsen, B. W., Mukaida, N., and Matsushima, K., Macrophages as producers of chemotactic proinflammatory cytokines. Immunol. Ser., 60, 131-142 (1994) 

  27. Reinders, M. E., van Wagensveld, B. A., van Gulik, T. M., Corssmit, N. P., Frederiks, W. M., Chamuleau, R. A., van Rooijen, N., and Obertop, H., No attenuation of ischemic and reperfusion injury in Kupffer cell-depleted, cold-preserved rat livers. Transplantation, 63, 449-454 (1997) 

  28. Renton, K. W., Factors affecting drug biotransformation. Clin. Biochem., 19, 72-75 (1986) 

  29. Schirmer, W. J., Schirmer, J. M., Townsend, M. C., and Fry, D. E., Femur fracture with associated soft-tissue injury produces hepatic ischemia. Arch. Surg., 123, 412-415 (1988) 

  30. Sewer, M. B., Koop, D. R., and Morgan, E. T., Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450. Drug Metab. Dispos., 24, 401-407 (1996) 

  31. Shedlofsky, S. I., Swim, A. T., Robinson, J. M., Gallichio, V. S., Cohen, P. A., and McClain, C. J., Interleukin-1 (IL-1) depresses cytochrome P450 levels and activities in mice. Life Sci., 40, 2331-2336 (1987) 

  32. Sonin, N. V., Garcia-Pagan, J. C., Nakanishi, K., Zhang, J. X., and Clemens, M. G., Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock, 11, 175-179 (1999) 

  33. Stadler, J., Trockfeld, J., Schmalix, W. A., Brill, T., Siewert, J. R., Greim, H., and Doehmer, J., Inhibition of cytochromes P4501A by nitric oxide. Proc. Natl. Acad. Sci. USA, 91, 3559-3563 (1994) 

  34. Stocker, R., Induction of haem oxygenase as a defence against oxidative stress. Free Radic. Res. Commun., 9, 101-112 (1990) 

  35. Takemura, S., Minamiyama, Y., Inaoka, S., Funae, Y., Hirohashi, K., Inoue, M., and Kinoshita, H., Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia. J. Hepatol., 30, 1035-1044 (1999) 

  36. Wu, J. Z., Ogle, C. K., Fischer, J. E., Warden, G. D., and Ogle, J. D., The mRNA expression and in vitro production of cytokines and other proteins by hepatocytes and Kupffer cells following thermal injury. Shock, 3, 268-273 (1995) 

  37. Zamora, R., Vodovotz, Y., Alarcon, L., Betten, B., Loughran, P. A., Aulak, K. S., Stuehr, D. J., Gibson, K. F., and Billiar, T. R., Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli. Arch. Biochem. Biophys., 390, 287-294 (2001) 

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