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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.26 no.12, 2003년, pp.1109 - 1116
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A series of 3'- and 4'-branched carbocyclic nucleosides 25, 26, 27, 28, 29 and 30 were synthesized starting from simple acyclic ketone derivatives. The construction of the required quaternary carbon was made using a [3,3]-sigmatropic rearrangement. In addition, the installation of a methyl group in ...
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Agrofoglio, L., Suhas, E., Farese, A., Condom, R., Challand, S., Earl, R. A., and Guedj, R., Synthesis of carbocyclic nucleosides. Tetrahedron, 50, 10611-10670 (1994)
Borthwick, A. D. and Biggadike, K., Synthesis of chiral carbocyclic nucleosides. Tetrahedron, 48, 571-623 (1992)
Chu, C. K., Ma, T. W., Shanmuganathan, K., Wang, C.-G., Xiang, Y.-J., Pai, S. B., Yao, G.-Q., Sommadossi, J.-P., and Cheng, Y.-C., Use of 2'-fluoro-5-methyl- $\beta$ -L-arabinofuranosyluracil as a novel antiviral agent for hepatitis-B virus and epstein-barr-virus. Antimicrob. Agents Chemother., 39, 979-981 (1995)
Chatis, P. A. and Crumpacker, C. S., Resistance of herpesvirus to antiviral drugs. Antimicrob. Agents Chemother., 36, 1589-1595 (1992)
Crimmins, M. T., King, B. W., Zuercher, W. J., and Choy, A. L., An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy. J. Org. Chem., 65, 8499-8500 (2000)
Daluge, S. M., Good, S. S., Faletto, M. B., Miller, W. H., StClair, M. H., Boone, L. R., Tisdale, M., Parry, N. R., Reardon, J. E., Dornsife, R. E., Averett, D. R., and Krenitsky, T. A., 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob. Agents Chemother., 41, 1082-1093 (1997)
Dienstag, J. L., Perrillo, R. P., Schiff, E. R. Bartholomew, M., Vicary, C., and Rubin, M., A preliminary trial of lamivudine for chronic hepatitis-B infection. New Engl. J. Med., 333, 1657-1661 (1995)
Furman, P. A. Fyfe, J. A., St. Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Nusinoff-Lehrman, S., Bolognesi, D. P., Broder, S., Mitsuya, H., and Barry, D. W., Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, 83, 8333-8337 (1986)
Jeong, L. S., Lee, Y. A., Moon, H. Y., and Chun, M. W., Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent. Nucleosides & Nucleotides, 17, 1479-1487 (1998)
Herdewijn, P., De Clercq, E., Balzarini, J., and Vanderhaeghe, H. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines. J. Med. Chem., 28, 550-555 (1985)
Hong, J .H., Gao, M. Y., and Chu, C. K., Synthesis of novel 3'-C-methyl-4'-thioapionucleosdies via highly enantioselective elaboration of quaternary carbon [3,3]-sigmatropic rearrangement. Tetrahedron Lett., 40, 231-234 (1999)
Hong, J. H., Gao, M. Y., Choi, Y., Cheng, Y.-C., Schinazi, and Chu, C. K., Synthesis of novel 3'-C-methylapionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement. Carbohydrate Res., 328, 37-48 (2000)
Hong, J. H., Shim, M. J., Ro, B. O., and Ko, O. H., An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose. J. Org. Chem., 67, 6387-6840 (2002)
Hong, J. H., Oh, C. H., and Cho, J. H., Stereocontrolled synthesis of novel 6'( $\alpha$ )-hydroxy carbovir analogues. Tetrahedron, 59, 6103-6108 (2003)
Kato, K., Suzuki, H., Tanaka, H., Miyasaka, T., Baba, M., Yamaguchi, K., and Akita, H., Stereoselective synthesis of 4- $\alpha$ -carbovir derivative based on an asymmetric synthesis of chemoenzymatic procedure. Chem. Pharm. Bull., 47, 1256-1264 (1999)
Kitano, K. and Miura, S., Synthesis of 4'-C-fluoromethyl-nucleosides as potential antineoplastic agents. Tetrahedron, 53, 13315-13322 (1997)
Levine, S., Hernandez, D., Yamanaka, G., Zhang, S., Rose, R., Weinheimer, S., and Colonno, R. J., Efficacies of entecavir against lamivudine-resistance hepatitis B virus replication and recombinant polymerase in vitro. Antimicrob. Agents Chemother., 46, 2525-2532 (2002)
Lin, T.-S., Schinazi, R. F., and Prusoff, W. H., Potent and selective in vitro activity of 3'-deoxythymidine-2'-ene-(3'-deoxy-2',3'-dideoxydehydrothymidine) against human immunodeficiency virus. Biochem. Pharmacol., 36, 2713-2718 (1987)
Lin, T. S., Luo, M. Z., Liu, M. C., Pai, S. B., Dutschman, G. E., and Cheng, Y.-C., Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human-immunodeficiency-virus (HIV) and hepatitis-B-virus (HBV). J. Med. Chem., 37, 798-803 (1994)
Martin, J. L., Brown, C. E., Mattews-Davis, N., and Reardon, J. E., Effects of antiviral nucleoside analogs on human DNA polymerase and mitochondrial DNA synthesis. Antimicrob. Agents Chemother., 38, 2743-2749 (1994)
Palmer, J. L. and Abeles, R. H., The mechanism of action of S-adenosylhomocysteinase. J. Biol. Chem., 254, 1217-1226 (1979)
Parker, W. B. and Cheng, Y. C., Mitochondrial toxicity of antiviral nucleoside analogues. J. NIH Res., 6, 57-61 (1994)
Shirasaka, T., Kavlick, M. F., Ueno, T., Gao, W. Y., Kojima, E., Alcaide, M. L., Chokekijchai, S., Roy, B. M., Arnol, E., Yarchoan, R., and Mitsuya, H., Emergence of human-immunodeficiency-virus type-1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc. Natl. Acad. Sci. USA, 92, 2398-2402 (1995)
Schinazi, R. F., Chu, C. K., Peck, A., McMillan, A., Mathis, R. Cannon, D., Jeong, L. S., Beach, J. W., Choi, W. B., Yeola, S., and Liotta, D. C., Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type I in human lymphocytes. Antimicrob. Agents Chemother., 36, 672-676 (1992)
Schinazi, R. F., McClure, H. M., Boudinot, F. D., Xiang, Y.-J., and Chu, C. K., Development of (-)- $\beta$ -D-2,6-diaminopurines dioxolane as a potential antiviral agent. Antiviral Res., 23, suppl. 81 (1994)
Ueland, P. M., Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase. Pharmacol. Rev., 34, 223-253 (1982)
Waga, T., Nishizaki, T., Miyakawa, J., Ohrui, H., and Meguro, H., Synthesis of 4'-C-methyl nucleosides. Biosci. Biotechnol. Biochem., 57, 1433-1438 (1993)
Yarchoan, R., Thomas, R. V., Allain, J.-P., McAtee, N., Dubinsky, R., Mitsuya, H., Lawley, T. J., Safai, B., Myers, C. E., Perno, C. F., Klecker, R. W., Wills, R. J., Fischl, M. A., McNeely, M. C., Pluda, J. M., Leuther, M., Collins, J. M., and Broder, S., The phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as single agent and alternating with zidovudine (AZT). Lancet, 1, 76-81 (1988)
Yarchoan, R., Mitsuya, H., Thomas, R. V., Pluda, J. M., Hartman, N. R., Perno, C. F., Marczyk, K. S., Allain, J.-P., Johns, D. G., and Broder, S., In vivo activity against HIV and favorable toxicity profile of 2',3'-dideoxyinosine. Science, 245, 412-415 (1989)
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