[논문]A New Lavandulylated Flavonoid with Free Radical and ONOO­Scavenging Activities from Sophora flavescens

Jung Hee Jin; Kang Sam Sik; Woo Ju Jung; Choi Jae Sue

doi:10.1007/bf02977897

[국내논문] A New Lavandulylated Flavonoid with Free Radical and ONOOScavenging Activities from Sophora flavescens 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.12, 2005년, pp.1333 - 1336

Jung Hee Jin (Faculty of Food Science and Biotechnology, Pukyong National University) , Kang Sam Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University) , Woo Ju Jung (Faculty of Food Science and Biotechnology, Pukyong National University) , Choi Jae Sue (Faculty of Food Science and Biotechnology, Pukyong National University)

Abstract ▼ AI-Helper

A new lavandulylated flavonoid, 8-lavandulylkaempferol (1), was isolated from the roots of Sophora f1avescens AITON (Leguminosae). The structure of this compound was determined via spectroscopic analysis. Compound 1 was determined to be a scavenger on both 1, 1-diphenyl2-picrylhydrazyl radicals and...

Keyword

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

제안 방법

, 2005). As the EtOAc fraction of the MeOH extract of this plant exhibited more profound scavenging activities on DPPH and ONOO- than the CH₂CI2 fraction, we conducted this study in order to identify the active compound(s) in the EtOAc fraction.

대상 데이터

자le (HR) FAB-MS spectra used in this study were provided by the Korea Basic Science Institute. This study was supported by a grant (05142HM625) from the National Center for Standardization of Herbal Medicine funded by the Food Drug & Administration, Republic of Korea (2005).

이론/모형

ONOO- scavenging activity was assessed by monitoring the oxidation of DHR 123, in accordance with a modified version of the method of Kooy et al. (1994). The DHR 123 (5 mM) in dimethylformamide, was purged with nitrogen, stored at -80℃, and used as a stock solution.

참고문헌 (21)

Blois, M. S., Antioxidant determination by the use of a stable free radical. Nature, 181, 1199-1202 (1958)

상세보기
Ding, P. L., Hou, A. J., and Chen, D. F., Three new isoprenylated flavonoids from the roots of Sophora flavescens. J. Asian Nat. Prod. Res., 7, 237-243 (2005)

상세보기
Ding, Y., Tian, R. H., Kinjo, J., Nohara, T., and Kitagawa, I., Three new oleanene glycosides from Sophora flavescens. Chem. Pharm. Bull., 40, 2990-2994 (1992)

상세보기
Harborne, J. B., Mabry, T. J., and Mabry, H., The Flavonoids, part I, Academic press, London, pp 100 (1975)
Huang, K. C., The Pharmacology of Chinese Herbs, CRC Press, Boca Raton, pp 63-66 (1993)
Jung, H. J., Kang, S. S., Hyun, S. K., and Choi, J. S., In vitro free radical and $ONOO^{-}$ scavengers from Sophora flavescens. Arch. Pharm. Res., 28, 534-540 (2005)

원문보기 상세보기
Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamato, T., Higuchi, R., and Kim, Y. C., Cytotoxic lavandulyl flavanones from Sophora flavescens. J. Nat. Prod., 63, 680-681 (2000)

상세보기
Kooy, N. W., Royall, J. A., Ischiropoulos, H., and Beckman, J. S., Peroxynitrite mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med., 16, 149-156 (1994)

상세보기
Kuroyanagi, M., Arakawa, T., Hirayama, Y., and Hayashi, T., Antibacterial and antiandrogen flavonoids from Sophora flavescens. J. Nat. Prod., 62, 1595-1599 (1999)

상세보기
Kyogoku, K., Hatayama, K., and Komatsu, M., Constituents of Chinese crude drug 'Kushen' (the root of Sophora flavescens Ait.). Isolation of five new flavonoids and formononetin. Chem. Pharm. Bull., 21, 2733-2738 (1973)

상세보기
Li, F. and Liy, Y. L., Studies on the isolation and structures of baohuoside II, III, IV, and V. Acta Pharmaceutica Sinica, 23, 672-681 (1988)

상세보기
Mabry, T. J., Markham, K. R., and Thomas, M. B., The Systematic Indentification of Flavonoids. Springer-Verlag, Berlin, pp 41-61 (1970)
Murakoshi, I., Kidoguchi, E., Haginiwa, J., Ohmiya, S., Higashiyama, K., and Otomasu, H., Isokuraramine and (-)- 7,11-dehydromatrine, lupin alkaloids from flowers of Sophora flavescens. Phytochemistry, 21, 2379-2384 (1982)

상세보기
Okuda, S., Murakoshi, I., Kamata, H., Kashida, Y., Haginiwa, J., and Tsuda, K., Studies on lupin alkaloids. I. The minor alkoloids of Japanese Sophora flavescens. Chem. Pharm. Bull., 13, 482-487 (1965)

상세보기
Perry, L. M. and Metzger, J., Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses. The MIT Press, Cambridge, pp 226 (1980)
Ruangrungsi, N., Iinuma, M., Tanaka, T., Ohyama, M., Yokoyama, J., and Mizuno, M., Three flavanones with a lavandulyl group in the roots of Sophora exigua. Phytochemistry, 31, 999-1001 (1992)

상세보기
Saito, K., Arai, N., Sekine, T., Ohmiya, S., Kubo, H., Otomasu, H., and Murakoshi, I., (-)-5 $\alpha$ -Hydroxysophocarpine, a new lupin alkaloid from the seeds of Sophora flavescens var. angustifolia. Planta Med., 56, 486-488 (1990)
Shirataki, Y., Tsuzuku, T., Yokoe, I., Hirano, R. T., and Komatsu, M., Studies on the constituents of Sophora species. XXIII. Constituents of the root of Sophora chrysophylla SEEM. Chem. Pharm. Bull., 38, 1712-1716 (1990)

상세보기
Woo, E. R., Kwak, J. K., Kim, H. J., and Park, H., A new prenylated flavonol from the roots of Sophora flavescens. J. Nat. Prod., 61, 1595-1599 (1998)
Wu, L. J., Miyasa, T., Ueno, A., Kuroyanagi, M., Noro, T., Fukushima, S., and Sasaki, S., Studies on the constituents of Sophora flavescens AITON. II. Chem. Pharm. Bull., 33, 3231- 3236 (1985)

상세보기
Yoshikawa, M., Wang, H. K., Kayakiri, T., Taniyama, T. and Kitagawa, I., Saponin and sapogenol. XL. Structure of sophoraflavoside I, a bisdesmoside of soyasapogenol B, from Sophorae Radix, the root of Sophora flavescens AITON. Chem. Pharm. Bull., 33, 4267-4274 (1985)

상세보기

저자의 다른 논문 :

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증