[논문]Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells

Heo, Ho-Jin; Lee, Hyun-Jae; Kim, Cheol-Su; Son, Kun-Ho; Kim, Young-Choong; Kim, Young-Sik; Kang, Sam-Sik; Park, Yang-Chun; Kim, Yun-Hee; Seo, Un-Kyo; Seok, Jeong-Ho; Lee, Choong-Jae

[국내논문] Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells 원문보기

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.10 no.6, 2006년, pp.317 - 321

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In this study, we investigated whether glycyrrhizin, prunetin and morroniside affect mucin secretion from cultured airway epithelial cells and compared the possible activities of these agents with the inhibitory action on mucin secretion by poly-L-lysine (PLL) and the stimulatory action by adenosine triphosphate (ATP). Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using $^{3}H-glucosamine$ for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on $^{3}H-mucin$ secretion. The results were as follows: 1) glycyrrhizin and morroniside increased basal mucin secretion from airway; 2) prunetin did not affect basal mucin secretion; 3) glycyrrhizin did not inhibit ATP-induced mucin secretion. We conclude that glycyrrhizin and morroniside can increase basal mucin secretion, by directly acting on airway mucin-secreting cells and suggest that two compounds be further investigated for the possible use as mild expectorants during the treatment of inflammatory airway diseases.

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Means of individual group were converted to percent control and expressed as mean S.E.M. The difference between groups was assessed using student's t-test for unpaired samples. p<0.

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