[논문]Stem Cell Biotechnology for Cell Therapy

LEE Dong-Ree; KIM Ha Won

Stem Cell Biotechnology for Cell Therapy 원문보기

The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology, v.13 no.4, 2005년, pp.199 - 206

LEE Dong-Ree (Department of Life Sciences, University of Seoul) , KIM Ha Won (Department of Life Sciences, University of Seoul)

Abstract ▼ AI-Helper

Cell therapy (CT) is a group of techniques to treat human disorders by transplantation of cells which have been processed and propagated independent of the living body. Blood transfusion and bone marrow transplant have been the primary examples of cell therapy. With introduction of stem cell (SC) technologies, however, CT is perceived as the next generation of biologies to treat human diseases such as cancer, neurological diseases, and heart disease. Despite potential of cell therapy, insufficient guidelines have been implemented concerning safety test and regulation of cell therapy. This review addresses the safety issues to be resolved for the cell therapy, especially SC therapy, to be successfully utilized for clinical practice. Adequate donor cell screening must preceed to ensure safety in cell therapy. In terms of SC culture, controlled, standardized practices and procedures should be established. Further molecular studies should be done on SC development and differentiation to enhance safety level in cell therapy. Finally, animal model must be further installed to evaluate toxicity, new concepts, and proliferative potential of SC including alternative feeder layer of animal cells.

주제어

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문제 정의

This review also addresses safety issues raised by recent advances in biological and medical research on cell therapy. In order to make arrangements for examining and reporting on such issues with regard to promoting understanding and discussion, this review deals with the potential guidelines by the appropriate regulatoiy systems.

제안 방법

Scientific efforts should be made on how the repertoire of responses of individual precursor cells becomes progressively restricted during development. These studies should cover the subjects as follow: External signals or factors that specify the phenotypic fate of neural precursor cells and scope of regulation achieved by environmental factors. Additional efforts are to be made to identify of the earliest phenotypic and antigenic changes that distinguish a restricted precursor cell from more pluripotent cells and development factors involved in known human disorders as well.
the back ground during these debates. This review examines safety issues raised by the potential of SCs derived from donated embryos, embryos created specifically for research purposes, fetal tissue and somatic cell nuclear transfer. This review also addresses safety issues raised by recent advances in biological and medical research on cell therapy.

후속연구

These studies should cover the subjects as follow: External signals or factors that specify the phenotypic fate of neural precursor cells and scope of regulation achieved by environmental factors. Additional efforts are to be made to identify of the earliest phenotypic and antigenic changes that distinguish a restricted precursor cell from more pluripotent cells and development factors involved in known human disorders as well.
In terms of SC culture, controlled, standardized practices and procedures should be established. Further molecular studies should be done on SC development and differentiation. Finely, animal model must be further installed to evaluate toxicity, new concepts, and proliferative potential of SC as well as to study alternative feeding by animal cells.
New drugs could be tested for safety and efficacy on cultured liver or skin cells derived from SCs before being tested on humans (Cogle, 2003). Further research on SCs also promises to improve our understanding of the complexities of normal human development.

참고문헌 (17)

Armson, B. A (2005). Maternal/fetal medicine committee, society of obstetricians and gynaecologists of Canada. Umbilical cord blood banking: implications for perinatal care providers. J. Obstet Gynaecol. Can. 27, 263-290
Aslam, I. , Fishel, S., Moore, H., Dowell, K. and Thornton, S. (2000). Fertility preservation of boys undergoing anti-cancer therapy: a review of the existing situation and prospects for the future. Hum. Reprod. 15, 2154-2159

상세보기
Bahadur, G. Ethics of testicular stem cell medicine. (2004). Hum Reprod., 19, 2702-2710

상세보기
Caplan, A. I. and Bruder, S. (2001). Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mo.l Mol. 7, 259-264

상세보기
Caulfield, T., Knowles, L. and Meslin, E. M. (2004). Law and policy in the era of reproductive genetics. J. Med. Ethics 30, 414-417

상세보기
Cogle, C. R., Guthrie, S. M., Sanders, R. C., Allen, W. L., Scott, E. W., and Petersen, B. E. (2003). An overview of stem cell research and regulatory issues. Mayo Clin. Proc. 78, 993-1003

상세보기
Deisseroth, A. B., Holmes, F, Hortobagyi, G. and Champlin, R. (1996). Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: a pilot trial. Hum. Gene Ther. 7, 401-16

상세보기
Hintzen, R. Q. (2002). Stem cell transplantation in multiple sclerosis: multiple choices and multiple challenges. Mult. Scler. 8, 155-160

상세보기
Kline, R. M., and Bertolone, S. J. (1998). Umbilical cord blood ？transplantation: providing a donor for everyone needing a bone marrow transplant? South. Med. J. 91, 821-828

상세보기
Parens, E. and Knowles, L. P. (2003). Reprogenetics and public policy. Reflections and recommendation. Hastings Cent. Rep. 33, 1-24
Prosper, F., Herreros, J. and Barba, J. (2004). Future perspectives in the treatment of heart failure: from cell transplantation to cardiac regeneration. Rev. Esp. Cardiol. 57, 981-988
Romano, G. (2004). Stem cell transplantation therapy: controversy over ethical issues and clinical relevance. Drug News Perspect. 17,637-645

상세보기
Schatten, G. P. (2002). Safeguarding ART. Nat. Cell Biol. 4 Suppl, 19-22

상세보기
Schwartz, R. S. and Curfman, G. D. (2002). Can the heart repair itself? N. Engl. J. Med. 346, 2-4

상세보기
Teshima, A. and Harada, M. (1997). Mobilization of peripheral blood progenitor cells for allogeneic transplantation. Cytokines Cell Mol. Ther. 3, 101-114
Testa, G. and Harris, J. (2005). Ethics and synthetic gametes. Bioethics 19, 146-166

상세보기
Yim, R. (2005). Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside. Transfusion 45, 144S-158

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