Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effec...
Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.
Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
문제 정의
This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task, which may provide clues for the clinical application of CMT to amnesia or dementia.
This study reveals a strategy for the creation of other oriental medically administered mammals with enhanced intelligence and memory. Further 운xp으riments on MNDA recepters should be progressed12-1.
제안 방법
All behavioural experiments were performed with the experimenter blind to the CMT-administered of each mouse.
CMT extract neither ameliorated the memory registration impairment caused by 30% ethanol, nor improved the memory consolidation deficit induced by electric convulsive shock when tested by the step through test.
A buzzer and a lamp were set on the ceiling and the grid floor of the box connected with an electric stimulator. The programme of one trial was as follows: (1) 40 sec interval; (2) 10 sec for conditional stimulation(CS)z (the warning buzzer and the lamp were operated on during this CS period); (3) 10 sec for unconditioned stimulation(US), (electric stimulation, an intensity of 36 V AC, as well as buzzer and lamp were operated on during the US period).
The training protocol consisted of six sessions(4 trials per session per day). The navigation of the mice was tracked by a videocamera and the escape latency to the platform was recorded.
대상 데이터
12 mice were randomly used in each group.
Experimental group was administered with 50 mg/100 g of CMT extract. 12 mice were used in each group.
The C57B/6 mice were used as experimental animals. Also, male mice of ddY-strain of 5-6 weeks old(KRIBB, Tawjon, Japan) were used.
데이터처리
trial(n-12). Data is expressed as mean + S.E. * : P<0.05 ** : P(0.01 between CMT-administered and wild-type mice, students t-test.
The results of the rate of the successful mice were analyzed by the chi-square test, novel object recognition task by Dunnetfs test, water maze task by Student's t-test. All the other data were analyzed by the Mann-Whitney's U-test
후속연구
Though further research is required to ehicidate the effects of CMT on memory and learning processes, the results presented in this paper may provide fundamental data for the study about the effects of CMT on the central nervous system.
참고문헌 (22)
Kim Jang-Hyun. Methodological Research in Development of Intelligence, The journal of korean oriental pediatrics, 13(2):95-96, 1999
Seo Young-Min. Review of Intelligence and Memory, The journal of korean oriental pediatrics, 13(1):152-159, 1999
Kyoung Sung-kang. Bibliographic Study on The function of the Brain on the Basis of Zangxang Theory, The journal of korean oriental medicine, 16(1):468, 1995
Choi Yong-Jun. A Bibliographic Study on the Type of Differential Diagnosis of Amnesia, The journal of korean oriental medicine, 17(1):374-376, 1996
Kim Youn-Doo. The bibliographic Study on The cause, Treatment Method and Medicine of Amnesia, The journal of korean oriental medicine, 13(1):216, 1980
Kim yong- wook. Study on Effect of Chongmyung-tang on Memory and Learning in memory impaired mice. Thesis of master, Daejun University, Daejun. Korea. 1998
Woo Ju- Yong. Study on effect of Jowisungcheongtang on the Learning and Memory of radial arm maze in mice. Thesis of master, Kyunghee University, Seoul, Korea, 1997
Lee Jae-Hee. Experimental Study on Correlation of Memory and Function of Kidneys. The journal of eastern physiology, 16(1):59, 1991
Hu Jun. dong-Eu-Bo-Gam, Seoul, Namsandang. 47, 1998
Segawa, M., Saito, N., Nishiyama, N. Biogenic Amines 7, 191-196, 1990
Zhou, Y., Saito, H., Nishiyama, N. Effects of Acorus gramineus Soland on learning and memory performances in mice. Shoyakugaku, 46, 103-108, 1992
Tsien, J.Z., Huerta, P.T., Tonegawa, S. The essential role of hippocampal CAI NMDA reeptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338, 1996
Myhrer, T. Exploratory behav. Neurosci. 102, 356-362, 1988
Mumby, D.G. Ischemia-induced object-recognition defects in rats are attenuated by hippocampal ablation before or soon after ischemia. Behav. Neurosci. 110, 266-281, 1996
Phillips, R.G., LeDoux, J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274-285, 1992
※ AI-Helper는 부적절한 답변을 할 수 있습니다.