[논문]Constituents of the Stems of Rumex japonicus with Advanced Glycation End Products (AGEs) and Rat Lens Aldose Reductase (RLAR) Inhibitory Activity

Kim, Jong-Min; Lee, Yun-Mi; Jang, Dae-Sik; Kim, Jin-Sook

Constituents of the Stems of Rumex japonicus with Advanced Glycation End Products (AGEs) and Rat Lens Aldose Reductase (RLAR) Inhibitory Activity 원문보기

Agricultural chemistry & biotechnology, v.49 no.1, 2006년, pp.24 - 27

Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) , Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) , Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) , Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)

Abstract ▼ AI-Helper

Four ursane-type triterpenoids, 2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (1), 4(R),23-epoxy-2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-12-en-28-oic acid (2), myrianthic acid (3), and tormentic acid (4), and a phenolic compound, ethyl gallate (5), from an EtOAc-soluble extract of the stems of Rumex japonicus, were subjected to in vitro bioassays to evaluate advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR) inhibitory activity. Compounds 1 and 5 exhibited a significant inhibitory activity on AGEs formation with $IC_{50}$ value of 87 ${\mu}M$ and on RLAR with $IC_{50}$ value of 14.3 ${\mu}M$, respectively. Ethyl gallate (5) was isolated for the first time from this plant.

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Constituents of the Stems of Rumex japonicus with Advanced Glycation End Products (AGEs) and Rat Lens Aldose Reductase (RLAR) Inhibitory Activity 원문보기

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Constituents of the Stems of Rumex japonicus with Advanced Glycation End Products (AGEs) and Rat Lens Aldose Reductase (RLAR) Inhibitory Activity 원문보기

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