최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기약학회지 = Yakhak hoeji, v.51 no.4, 2007년, pp.264 - 269
임재윤 (우석대학교 약학대학) , 이일화 (우석대학교 약학대학) , 이경아 (우석대학교 약학대학) , 공두균 (우석대학교 약학대학) , 최부진 (우석대학교 약학대학) , 이충수 (우석대학교 약학대학) , 은재순 (우석대학교 약학대학)
Alzheimer’s disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
Vellas, B. and Fitten, L. J. : Research and Practice in Alzheimer's disease. Springer Publishing Co. (2000)
Sugimoto, H. : Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem. Rec. 1, 63 (2001)
Zarotsky, V., Sramek, J. J. and Cutler, N. R. : Galantamine hydrobromide: an agent for Alzheimer's disease. Am. J. Health Syst. Pharm. 60, 446 (2003)
Jann M. W. : Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease. Pharmacotherapy 20, 1 (2000)
Iqbal, K., Sisodia, S. S. and Winblad, B. : Alzheimer's Disease: Advances in Etionlogy, Pathogenesis and Therapeutics. John Wiley & Sons, Ltd. (2001)
Morris, J. C. : Classification of dementia and Alzheimer's disease. Acta Neurol. Scand. 165, 41 (1996)
Braak, H., Braak, E. and Strothjohann, M. : Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett. 171, 1 (1994)
Kang, J, Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K. and Muller-Hill, B. : The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733 (1987)
Selkoe, D. J. : The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447 (1998)
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D. and Roses, A. D. : Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 8098 (1993)
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L. and Pericak-Vance, M. A. : Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921 (1993)
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G. and Citron, M. : ${\beta}$ -Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735 (1999)
Selkoe, D. J. : Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399, 23 (1999)
Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L. S., Sorbi, S., Bruni, A., Fraser, P. and St. George-Hyslop, P. : Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407, 48 (2000)
Lee, S. F., Shah, S., Li, H., Yu, C., Han, W. and Yu, G. : Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J. Biol. Chem. 277, 45013 (2002)
Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M. and Haass, C. : PEN-2 is an integral component of the -secretase complex required for coordinated expression of presenilin and nicastrin. J. Bioi. Chem. 277, 39062 (2002)
Hardy, J. and Selkoe, D. J. : The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353 (2002)
Cai, H., Wang, Y., McCarthy, D., Wen, H., Borchelt, D. R., Price, D. L. and Wong, P. C. : BACE1 is the major ${\beta}$ -secretase for generation of A peptides by neurons. Nature Neurosci. 4, 233 (2001)
Delmotte, P. and Delmotte-Plaquee, J. : A new antifungal substance of fungal origin. Nature 171, 344 (1953)
Wang, R., Sweeney, D., Gandy, S. E. and Sissodia, S. S. : The profile of soluble amyloid protein in cultured cell media. J. Biol. Chem. 271, 31894 (1996)
Tung, J. S., Davis, D. L., Anderson, J. P., Walker, D. E., Mamo, S., Jewett, N., Hom, R. K., Sinha, S., Thorsett, E. D. and John, V. : Design of substrate-based inhibitors of human beta-secretase. J. Med. Chem. 45, 259 (2002)
Kinoshita, A., Fukumoto, H., Shah, T., Whelan, C. M., Irizarry, M. C. and Hyman, B. T. : Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J. Cell. Sci. 116, 3339 (2003)
Leern, J. Y., Saura, C. A., Pietrzik, C., Christianson, J., Wanamaker, C., King, L. T., Veselits, M. L., Tomita, T., Gasparini, L., Iwatsubo, T., Xu, H., Green, W. N., Koo, E. H. and Thinakaran, G. : A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol. Dis. 11, 64 (2002)
Sambamurti, K., Hardy, J., Refolo L. M. and Lahiri, D. K. : Targeting APP metabolism for the treatment of Alzheimer's disease. Drug Dev. Res. 56, 211 (2002)
Prodromou, C., Roe, S. M., O'Brien, R., Ladbury, J. E., Piper, P. W. and Pearl, L. H. : Identification and structural characterization of the ATP/ADP-binding site in the HSP90 molecular chaperone, Cell 90, 65 (1997)
Goetz, M. P., Toft, D. O., Ames, M. M. and Erlichman, C. : The Hsp90 chaperone complex as a novel target for cancer therapy. Annals of Oncology 14, 1169 (2003)
Schulte, T. W., Akinaga, S., Soga, S., Sullivan, W., Stensgard, B., Toft, D. and Neckers, L. M. : Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 3, 100 (1998)
Skovronsky, D. M., Moore, D. B., MilIa, M. E., Doms, R. W. and Lee, V. M. : Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J. Biol. Chem. 275, 2568 (2000)
Nunan, J. and Small, D. H. : Regulation of APP cleavage by alpha-, beta- and gamma-secretases. FEBS Lett. 483, 6 (2000)
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St George Hyslop, P. and Selkoe, D. J. : Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67 (1997)
Kuo, Y. M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J. and Roher, A. E. : Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. BioI. Chem. 271, 4077 (1996)
Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T. and Iwatsubo, T. : Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J. Biol. Chem. 278, 18664 (2003)
Eun, J. S., Lee, K. A., Li, R., Choi, B. J. and Leem, J. Y : The effects of geldanamycin on the metabolism of APP. submitted
Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke-Haerter, P. J., Smith, M. A., Perry, G. and Shimohama, S. : Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J. 16, 601 (2002)
※ AI-Helper는 부적절한 답변을 할 수 있습니다.