[논문]Flavonol Glycosides with Antioxidant Activity from the Aerial Parts of Epimedium koreanum Nakai

Kim, Eun-Sil; Kim, Mi-Kyung; Kang, Hyun-Kyu; Park, Young-In; Dong, Mi-Sook; Kim, Dong-Hyun; Chung, Ha-Sook

[국내논문] Flavonol Glycosides with Antioxidant Activity from the Aerial Parts of Epimedium koreanum Nakai 원문보기

Natural product sciences, v.14 no.4, 2008년, pp.233 - 238

Kim, Eun-Sil (College of Natural Sciences, DukSung Women's University) , Kim, Mi-Kyung (College of Natural Sciences, DukSung Women's University) , Kang, Hyun-Kyu (College of Life Sciences and Biotechnology, Korea University) , Park, Young-In (College of Life Sciences and Biotechnology, Korea University) , Dong, Mi-Sook (College of Life Sciences and Biotechnology, Korea University) , Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) , Chung, Ha-Sook (College of Natural Sciences, DukSung Women's University)

Abstract ▼ AI-Helper

The aerial parts of Epimedium koreanum Nakai have been used to stimulate hormone secretion in treating impotence. Ten flavonol glycosides, 3,4,5-trihydroxy-8-prenylflavone 7-O-[${\beta}$-D-glucopyranosyl($1{\rightarrow}2$)-${\beta}$-D-glucopyranoside] (1), hyperoside (2), icarisid II (3), 2"-O-Rhamnosylicarisid II (4), epimedin A (5), epimedin B (6), epimedin C (7), icariin (8), hexandraside E (9), and epimedoside A (10) were isolated from the an ethylacetate soluble extracts of the aerial parts of Epimedium koreanum Nakai through activity-monitord fractionation and isolation method. The structures of compounds 1 - 10 were elucidated by high resolution fast atom bombardment mass spectrometry and two dimentional nuclear magnetic resonance spectroscopy analysis. Compounds 1 and 4 showed potent antioxidant activity, with $IC_{50}$ values of 19.7 and 11.5 ${\mu}g$/mL and 88.2 and 90.5 ${\mu}M$, respectively.

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4 mg), respectively. Complete identification of isolated compounds made use of varieties of physical and chemical techniques, HR-FABMS, Positive and Negative FABMS spectrometry, UV/Visible spectrophotometry, ¹HNMR, ¹³C-NMR, DEPT, COSY, HMQC and HMBC spectroscopy (Fig. 1).

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