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NTIS 바로가기대한방사선종양학회지 = The Journal of the Korean soceity for therapeutic radiology and oncology, v.26 no.3, 2008년, pp.142 - 148
지의규 (서울대학교 의과대학 방사선종양학교실) , 김규보 (서울대학교 의과대학 방사선종양학교실) , 최진화 (서울대학교 의과대학 방사선종양학교실) , 장나영 (서울대학교 의과대학 방사선종양학교실) , 한원식 (서울대학교 의과대학 외과학교실) , 노동영 (서울대학교 의과대학 외과학교실) , 임석아 (서울대학교 의과대학 내과학교실) , 김태유 (서울대학교 의과대학 내과학교실) , 방영주 (서울대학교 의과대학 내과학교실) , 하성환 (서울대학교 의과대학 방사선종양학교실)
Purpose: We analyzed the treatment outcomes and prognostic factors of breast conserving surgery, followed by postoperative radiotherapy.Materials and Methods: A total of 424 breast cancer patients treated with breast conserving surgery and postoperative radiotherapy between February 1992 and January...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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최근 유방암의 치료에 있어서 유방 보존술의 적용이 더욱 늘어날 것으로 전망하는 이유는 무엇인가? | 33,34) 뿐만 아니라 Early Breast Cancer Trialists' Collaborative Group에서 시행한 메타분석에서는, 유방보존수술 후 방사선치료가 생존율에는 영향을 미치지 못한다는 기존 연구결과와는 달리, 방사선치료 후 15년이 경과하였을 때 생존율의 향상을 보고 하였다.35) 최근에는 항암화학요법의 발달로 선행항암화학요법을 시행한 후 유방보존수술을 시행하는 경우, 국소재발률이나 생존율에는 차이가 없으면서 유방보존율을 높일수 있음이 밝혀지면서 유방보존술의 적용이 더욱 늘어날 전망이다.36,37) | |
현재까지 보고된 6개의 전향적 무작위 연구에서 유방보존술의 국소 재발률은 어떻게 나타나는가? | 현재까지 보고된 6개의 전향적 무작위 연구에서 유방보존술의 국소재발률은 3∼20% 정도로, 다른 연구에 비해 비교적 높은 국소재발률을 보고하고 있는 두 연구를 제외하면,19,20) 대체로 10% 정도의 국소재발률을 보이고 있다.1∼4)본 연구에서는 추적기간이 짧기는 하나 국소재발률이 4. | |
유방보존술은 치료 목적 외에도 어떤 장점을 가지는가? | 1970∼80년대 유방 전적출술과 유방보존술을 비교한 여러 전향적 무작위연구에서 유방보존수술 및 방사선치료가 유방 전적출술과 동일한 장기 무병생존율을 얻을 수 있음을 보고한 이후,1∼4) 1990년 미국 National Institutes of Health (NIH) 회의에서는 유방보존술이 대부분의 조기유방암에 적절한 치료법이라는 합의에 도달하였다.5) 뿐만 아니라, 유방보존술은 미용 및 정신적 만족을 줌으로써 환자의 삶의 질 측면에서도 도움이 되어,6) 조기유방암의 표준치료로 자리를 잡았다. 구미지역에서는 지역에 따라 유방암 환자의 25∼60%에서 유방보존술이 시행되고 있고,7) 국내에서도 유방암 발생의 증가와 함께 유방보존술의 적용이 점진적으로 증가하고 있다. |
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