다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Ocean and polar research, v.30 no.1, 2008년, pp.109 - 117
정지현 (한국해양연구원 남해연구소) , 류태권 (한국해양연구원 남해연구소) , 이택견 (한국해양연구원 남해연구소)
AI-Helper
Application of biomarkers for assessing marine environmental health risk is a relatively new field. According to the National Research Council and the World Health Organization, biomarkers can be divided into three classes: biomarkers of exposure, biomarkers of effect, and biomarkers of susceptibili...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 국립학술원 및 세계보건기구에 따르면 바이오마커는 어떻게 나뉘는가? | 해양환경 건강성 평가에서 바이오마커의 적용은 상대적으로 새로운 분야이다. 국립학술원 및 세계보건기구에 따르면 바이오마커는 노출바이오마커, 영향바이오마커 및 민감바이오마커 등 3가지로 나누어진다. 해양생태계에 대한 환경오염물질의 노출 및 영향을 평가하기 위하여 다음과 같은 바이오마커들이 시험되고 있다: 해독, 산화스트레스, 분해산물, 스트레스 반응, 세포사멸, 물질대사, 신경반응, 생식, 스테로이드 호르몬, 항산화물질, 유전적 변형. | |
| 생태위해성 또는 환경위해성 평가는 어떤 방법인가? | 생태위해성 또는 환경위해성 평가(ecological or environmental risk assessment, ERA)는 생태계에 대한 오염물질 및 다른 인위적인 활동의 악영향을 생태계 수준에서 과학적으로 측정하는 방법이다(Depledge and Fossi 1994). 오염물질로 인한 스트레스에 대한 반응은 생물계내의 영양단계에 따라 다양하게 나타나며 개체 수준에서부터 생태계 수준으로 높아질수록 오염에 대한 반응을 확인하는데 오랜 시간이 소요되며, 때로는 생물체내에서 화학적 방법으로 검출되지는 않는 수준에서부터 과다한 오염영향에 대하여 변형된 생물반응을 보이는 경우도 있다. | |
| 쓸개즙 대사물질 농도는 어떻게 분석가능한가? | 1992). 쓸개에서의 대사물질의 농도는 형광방향성화합물(fluorescent aromatic compounds)의 형태로 변환된 PAH 대사물질의 농도를 측정하거나 전체 PAH 대사를 나타내는 하나의 대사물질을 선택함으로써 분석할 수 있다(Krahn et al. 1987; Ariese et al. 1993). PAH 대사물질은 형광분석기나 HPLC 등으로 측정한다(Aas et al. 2000). |
Aas, E., T. Baussant, L. Balk, B. Liewenborg, and O.K. Andersen. 2000. PAH metabolites in bile, cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: A laboratory experiment with Atlantic cod. Aquat. Toxicol., 51, 241-258
Adams, S.M., A.M. Brown, and R.W. Goede. 1993. A quantitative health assessment index for rapid evaluation of fish condition in the field. Trans. Am. Fish. Soc., 122, 63-73
Adams, S.M., K.D. Ham, M.S. Greeley, R.F. LeHew, D.E. Hinton, and C.F. Saylor. 1996. Downstream gradients in bioindicator responses: Point source contaminant effects on fish health. Can. J. Fish. Aquat. Sci., 53(10), 2177-2187
Adams, S.M., L.R. Shugart, G.R. Southworth, and D.E. Hinton. 1990. Application of bioindicators in assessing the health of fish populations experiencing contaminant stress. p. 333-353. In: Biomarkers of environmental contamination, ed. by J.F. McCarthy and L.R. Shugart. Lewis, Boca Raton
Ankley, G.T., V.S. Blazer, R.E. Reinert, and M. Agosin. 1986. Effects of Aroclor 1254 on cytochrome P-450- dependent monooxygenase, glutathione-S-transferase, and UDP-glucuronosyltransferase activities in channel catfish liver. Aquat. Toxicol., 9, 91-103
Ariese, F., S.J. Kok, M. Verkaik, C. Gooijer, N.H. Velthorst, and J.W. Hofstraat. 1993. Synchronous fluorescence spectrometry of fish bile: Arapid screening method for the biomonitoring of PAH exposure. Aquat. Toxicol., 26, 273-286
Arukwe, A., L. Forlin, and A. Goksoyr. 1997. Xenobiotic and steroid biotransformation enzymes in Atlantic salmon (Salmo salar) liver treated with an estrogenic compound, 4-nonylphenol. Environ. Toxicol. Chem., 16(12), 2576-2583
Beliaeff, B. and T. Burgeot. 2002. Integrated biomarker response: A useful tool for ecological risk assessment. Environ. Toxicol. Chem., 21(6), 1316-1322
Binelli, A., F. Ricciardi, C. Riva, and A. Provini. 2005. Screening of POP pollution by AChE and EROD activities in Zebra mussels from the Italian Great Lakes. Chemosphere, 61, 1074-1082
Binelli, A., F. Ricciardi, C. Riva, and A. Provini. 2006. New evidences for old biomarkers: Effects of several xenobiotics on EROD and AChE activities in Zebra mussel (Dreissena polymorpha). Chemosphere, 62, 510- 519
Brodeur, J.C., C. Girard, and A. Hontela. 1997. Use of perifusion to assess in vitro the functional integrity of interrenal tissue in teleost fish from polluted sites. Environ. Toxicol. Chem., 16(10), 2171-2178
Broeg, K., H.V. Westernhagen, S. Zander, W. Korting, and A. Koehler. 2005. The “bioeffect assessment index” (BAI): A concept for the quantification of effects of marine pollution by an integrated biomarker approach. Mar. Pollut. Bull., 50(5), 495-503
Broeg, K. and K.K. Lehtonen. 2006. Indices for the assessment of environmental pollution of the Baltic Sea coasts: Integrated assessment of a multi-biomarker approach. Mar. Pollut. Bull., 53, 508-522
Brown, P.J., S.M. Long, D.J. Spurgeon, C. Svendsen, and P.K. Hankard. 2004. Toxicological and biochemical responses of the earthworm Lumbricus rubellus to pyrene, a non-carcinogenic polycyclic aromatic hydrocarbon. Chemosphere, 57(11), 1675-1681
Bucheli, T.D. and K. Kent. 1995. Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems. Crit. Rev. Enciron. Sci. Technol., 25(3), 201-268
Cairns, J., P.V. McCormick, and B.R. Niederlehner. 1993. A proposed framework for developing indicators of ecosystem health. Hydrobiologia, 263(1), 1-44
Chevre, N., F. Gagne, P. Gagnon, and C. Blaise. 2003. Application of rough sets analysis to identify polluted aquatic sites based on a battery of biomarkers: A comparison with classical methods. Chemosphere, 51(1), 13-23
Coughlan, D.J., B.K. Baker, D.G. Cloutman, and W.M. Rash. 1996. Application and modification of the fish health assessment index used for largemouth bass in the Catawba River, North Carolina-South Carolina. p. 73-84. In: Multidimensional approaches to reservoir fisheries management: Proc. 3rd national reservoir fisheries Symp., Chattanooga, Tennessee, USA, June 12-14, 1995
De la Torre, F.R., A. Salibian, and L. Ferrari. 2000. Biomarkers assessment in juvenile Cyprinus carpio exposed to waterborne cadmium. Eviron. Pollut., 109(2), 277-282
Depledge, M.H. and M.C. Fossi. 1994. The role of biomarkers in environmental assessment (2). Invertebrates. Ecotoxicology, 3(3), 161-172
Escher, M., T. Wahli, S. Buettner, W. Meier, and P. Burkhardt-Holm. 1999. The effect of sewage plant effluent on brown trout (Salmo trutta fario): A cage experiment. Aquat. Sci., 61(2), 93-110
Fernandez-Alba, A.R., M.D. Hernando, L. Piedra, and Y. Chisti. 2002. Toxicity evaluation of single and mixed antifouling biocides measured with acute toxicity bioassays. Anal. Chim. Acta, 456(2), 303-312
Galgani, F., G. Bocquene, and Y. Cadiou. 1992. Evidence of variation in cholinesterase activity in fish along a pollution gradient in the North Sea. Mar. Ecol.-Prog. Ser., 91, 77-82
Garvey, J.S. 1990. Metallothionein: A potential biomonitor of exposure to environmental toxins. p. 267-287. In: Biomarkers of environmental contamination, ed. by J.F. McCarthy and L.R. Shugar. Lewis, Boca Raton
Giesy, X.P. and R.L. Graney. 1988. A review of selected clinical indicators of stress-induced changes in aquatic organisms. p. 160-201. In: Toxic contaminants and ecosystem health: A great lakes focus, ed. by M.S. Evans. John Wiley & Sons, New York
Hagger, J.A., A.S. Fisher, S.J. Hill, M.H. Depledge, and A.N. Jha. 2002. Genotoxic, cytotoxic and ontogenetic effects of tri-n-butyltin on the marine worm, Platynereis dumerilii (Polychaeta: Nereidea). Aquat. Toxicol., 57(4), 243-255
Heffernan, L.M. and G.W. Winston. 2000. Distribution of microsomal CO-binding chromophores and EROD activity in sea anemone tissues. Mar. Environ. Res., 50, 23-27
Holdway, D.A., S.E. Brennan, and J.T. Ahokas. 1995. Short review of selected fish biomarkers of xenobiotic exposure with an example using fish mixed-function oxidase. Aust. J. Ecol., 20(1), 34-44
Hontela, A., P. Dumont, D. Duclos, and R. Fortin. 1995. Endocrine and metabolic dysfunction in yellow perch, Perca flavescens, exposed to organic contaminants and heavy metals in the St. Lawrence River. Environ. Toxicol. Chem., 14(4), 725-731
Hylland, K., M. Sandvik, J.U. Skare, J. Beyer, E. Egaas, and A. Goksoyr. 1996. Biomarkers in flounder (Platichthys flesus): An evaluation of their use in pollution monitoring. Mar. Environ. Res., 42, 223-227
Janz, D.M., M.E. McMaster, K.R. Munkittrick, and G. van der Kraak. 1997. Elevated ovarian follicular apoptosis and heat shock protein-70 expression in white sucker exposed to bleached kraft pulp mill effluent. Toxicol. Appl. Pharmacol., 147(2), 391-398
Kammann, U., M. Friedrich, and H. Steinhart. 1996. Isolation of a metal-binding protein from ovaries of dab (Limanda limanda L.) distinct from metallothionein: Effect of cadmium exposure. Ecotox. Environ. Safe., 33(3), 281-288
Klaverkamp, J.F., W.A. Macdonald, D.A. Duncan, and R. Wagemann. 1984. Metallothionein and acclimation to heavy metals in fish: A review. p. 99-113. In: Contaminant effects on fisheries, ed. by V.W. Cairns, P.V. Hodson and J.O. Nriagu. Wiley. New York
Konradt, J. and T. Braunbeck. 2001. Alterations of selectes metabolic enzymes in fish following long-term exposure to contaminated streams. J. Aquat. Ecosyst. Stress Recov., 8, 299-318
Krahn, M.M., D.G. Burrows, W.D. MacLeod, and D.C. Malins. 1987. Determination of individual metabolites of aromatic compounds in hydrolyzed bile of English sole (Parophrys vetulus) from polluted sites in Puget Sound, Washington. Arch. Environ. Contam. Toxicol., 16, 511- 522
Kurelec, B. 1992. The multixenobiotic resistance mechanism in aquatic organisms. Crit. Rev. Toxicol., 22, 23-43
Levine, S.L., X.T. Oris, and T.E. Wissing. 1995. Influence of environmental factors on the physiological condition and hepatic ethoxyresorufin-O-deethylase (EROD) activity of gizzard shad (Dorosoma cepedianum). Environ. Toxicol. Chem., 14, 123-128
Machala, M., K. Nezveda, M. Petrivalsky, A.B. Jarosova, V. Piacka, and Z. Svobodova. 1997. Monooxygenase activities in carp as biochemical markers of pollution by polycyclic and polyhalogenated aromatic hydrocarbons: Choice of substrates and effects of temperature, gender and capture stress. Aquat. Toxicol., 37, 113-123
McCarty, L.S. and K.R. Munkittrick. 1996. Environmental biomarkers in aquatic toxicology: Fiction, fantasy or functional? Human Ecol. Risk Assess., 2(2), 268-274
Melancon, M.J., R. Alscher, W. Benson, G. Kruzynski, R.F. Lee, H.C. Sikka, and R.B. Spies. 1992. Metabolic products as biomarkers. p. 87-124. In: Biomarkers: Biochemical, Physiological and Histological Markers of Anthropogenic Stress, ed. by R.J. Huggett, R.A. Kimerly, P.M. Mehrle and H.L. Bergman. Lewis, Boca Raton
Napierska, D. and M. Podolska. 2005. Biomarkers of contaminant exposure: Results of a field study with flounder (Platichthys flesus) from the southern Baltic Sea. Mar. Pollut. Bull., 50(7), 758-767
Narbonne, J.M., M. Daube, C. Clerandeau, and P. Garrigues. 1999. Scale of classification based on biochemical markers in mussels: Application to pollution monitoring in European coasts. Biomarkers, 4(6), 415-424
Overnell, J., R. McIntosh, and T.C. Fletcher. 1987. The level of liver metallothionein and zinc in plaice, Pleuronectes platessa L., during the breeding season, and the effect of estradiol injection. J. Fish Biol., 30, 539-546
Peakall, D.W. 1994. Biomarkers: The way forward in environmental assessment. Toxicol. Ecotoxicol. News, 1, 55-60
Piechotta, G., M. Lacorn, T. Lang, U. Kammann, T. Simat, H.S. Jenke, and H. Steinhart. 1999. Apoptosis in dab (Limanda limanda) as possible new biomarker for anthropogenic stress. Ecotox. Environ. Safe., 42(1), 50- 56
Schleiger, S.L. 2004. Fish health assessment index study of four reservoirs in West-Central Georgia. North Am. J. Fisheries Manage., 24(4), 1173-1188
Sherry, J.P. 2003. The role of biomarkers in the health assessment of aquatic ecosystems. Aquat. Ecosyst. Health Manage., 6(4), 423-440
Stegeman, J.J. and M.E. Hahn. 1994. Biochemistry and molecular biology of monooxygenase: Current perspective on forms, functions, and regulation of cytochrome P450 in aquatic species. p. 87-206. In: Aquatic toxicology: Molecular, Biochemical and Cellular Perspectives, ed. by D.C. Malins and G.K. Ostrander. Lewis, Boca Raton
Sturm, A., H.C. da Silva de Assis, and P.D. Hansen. 1999. Cholinesterases of marine teleost fish: Enzymological characterization and potential use in the monitoring of neurotoxic contamination. Mar. Environ. Res., 47(4), 389-398
Sturm, A., J. Wogram, H. Segner, and M. Liess. 2000. Different sensitivity to organophosphates of acetylcholinesterase and butyrylcholinesterase from threespined stickleback (Gasterosteus aculeatus): Aapplication in biomonitoring. Environ. Toxicol. Chem., 19(6), 1607- 1615
Vaccaro, E., V. Meucci, L. Inotorre, D. Soldani, D. Di bello, V. Longo, P.G. Gervasi, and C. Pretti. 2005. Effects of 17- ${\beta}$ -estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Aquat. Toxicol., 75(4), 293-305
Van der Oost R., A. Goksoyr, M. Celander, H. Heida, and N.P.E. Varmeulen. 1996. Biomonitoring of aquatic pollution with feral eel (Anguilla anguilla), II. Biomarkers: Pollution-induced biochemical responses. Aquat. Toxicol., 36, 189-222
Yuan, Z., S. Courtenay, and I. Wirgin. 2006. Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquat. Toxicol., 76, 306-320
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.